1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Research News and Information

Monday, November 23, 2009

Acute and chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administrations elicit similar microglial activation in the substantia nigra of monkeys.

30 Aug 2009 Increasing evidence suggests a pivotal role for neuroinflammation in the pathogenesis of Parkinson disease, but whether activated microglia participate in disease progression remains unclear. To clarify this issue, we determined the numbers of ... Read more...

TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP(+).

17 Aug 2009 Disturbances in Ca(2+) homeostasis have been implicated in a variety of neuropathological conditions including Parkinson's disease (PD). However, the importance of store-operated Ca(2+) entry (SOCE) channels in PD remains to be investigated. In the ... Read more...

Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.

26 Jul 2009 Sirtuin 1 (SIRT1) is the closest mammalian homologue of yeast silent information regulator 2 (Sir2) and has a role in lifespan modulation. Reportedly, SIRT1 is also linked to neurodegenerative diseases. However, there are limited studies that report ... Read more...

Latest indexed articles for '1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine'

These are the very latest articles for this heading:

• Acute and chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administrations elicit similar microglial activation in the substantia nigra of monkeys. 30 Aug 2009
• TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP(+). 17 Aug 2009
• Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection. 26 Jul 2009
• MPTP administration increases plasma levels of acute phase proteins in non-human primates (Macaca fascicularis). 24 Jul 2009
• Sleep disorders in Parkinson's disease: the contribution of the MPTP non-human primate model. 23 Jul 2009
• Quantification of Paraquat, MPTP, and MPP+ in brain tissue using microwave-assisted solvent extraction (MASE) and high-performance liquid chromatography-mass spectrometry. 17 Jul 2009
• Macroautophagy of the GPR37 orphan receptor and Parkinson disease-associated neurodegeneration. 7 Jul 2009
• [Dynamics of spectral parameters of the rat brain electrical activity in the model of depressive pain syndrome] 29 Jun 2009
• Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's disease. 29 Jun 2009
• Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling. 15 Jun 2009
• Evidence for a dopaminergic innervation of the pedunculopontine nucleus in monkeys, and its drastic reduction after MPTP intoxication. 10 Jun 2009
• Effect of caffeine on the expression of cytochrome P450 1A2, adenosine A2A receptor and dopamine transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum. 7 Jun 2009
• Two new test methods to quantify motor deficits in a marmoset model for Parkinson's disease. 6 Jun 2009
• The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection. 30 May 2009
• Not lost in translation Sensing the loss and filling the gap during regeneration. 18 May 2009
• Effect of estradiol on striatal dopamine activity of female hemiparkinsonian monkeys. 13 May 2009
• Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons. 9 May 2009
• Activation of p38 MAPK in the substantia nigra leads to nuclear translocation of NF-kappaB in MPTP-treated mice: implication in Parkinson's disease. 9 May 2009
• Strain-specific sensitivity to MPTP of C57BL/6 and BALB/c mice is age dependent. 4 May 2009
• Neuroprotective actions of sex steroids in Parkinson's disease. May 2009

See a longer list of these articles.

Technical information about '1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine'

Definition: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

Chemical name: Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-

Registry Number: 28289-54-5

Descriptor UI: D015632

Alternative terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; radiation effects; standards; supply & distribution; therapeutic use; urine; chemistry; contraindications; agonists;

Pharmacological Action: Dopamine Agents; Neurotoxins;

Tree Number: D03.383.725.450;

History Note: 90