2-Amino-5-phosphonovalerate
Research News and Information

Monday, November 23, 2009

Metaplasticity governs natural experience-driven plasticity of nascent embryonic brain circuits.

27 Oct 2009 During embryogenesis, brain neurons receiving the same sensory input may undergo potentiation or depression. While the origin of variable plasticity in vivo is unknown, it plays a key role in shaping dynamic neural circuit refinement. Here, we ... Read more...

Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation.

29 Sep 2009 A hypofunction of the N-methyl-D-aspartate (NMDA) receptor has been implicated in the pathophysiology of schizophrenia. Compelling evidence of altered NMDA receptor subunit expression in the schizophrenic brain has not, however, so far emerged. Rats ... Read more...

The timing of external input controls the sign of plasticity at local synapses.

4 Sep 2009 The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local ... Read more...

Latest indexed articles for '2-Amino-5-phosphonovalerate'

These are the very latest articles for this heading:

• Metaplasticity governs natural experience-driven plasticity of nascent embryonic brain circuits. 27 Oct 2009
• Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation. 29 Sep 2009
• The timing of external input controls the sign of plasticity at local synapses. 4 Sep 2009
• Blockade of NMDA receptors and nitric oxide synthesis in the dorsolateral periaqueductal gray attenuates behavioral and cellular responses of rats exposed to a live predator. 13 Aug 2009
• Recruitment of N-Type Ca(2+) channels during LTP enhances low release efficacy of hippocampal CA1 perforant path synapses. 11 Aug 2009
• Synaptic potentiation induces increased glial coverage of excitatory synapses in CA1 hippocampus. 30 Jul 2009
• The vasodilatory effect of ketamine is independent of the N-methyl-D-aspartate receptor: lack of functional N-methyl-D-aspartate receptors in rat mesenteric artery smooth muscle. 30 Jul 2009
• Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. 28 Jul 2009
• Stimulation of NMDA and AMPA glutamate receptors elicits distinct concentration dynamics of nitric oxide in rat hippocampal slices. 29 Jun 2009
• Burst-timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons. 23 Jun 2009
• High-frequency magnetic stimulation induces long-term potentiation in rat hippocampal slices. 15 Jun 2009
• Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. 15 Jun 2009
• Optical imaging of postsynaptic odor representation in the glomerular layer of the mouse olfactory bulb. 25 May 2009
• Pharmacological intervention of hippocampal CA3 NMDA receptors impairs acquisition and long-term memory retrieval of spatial pattern completion task. 21 May 2009
• N-Methyl-D-aspartate receptor antagonist d-AP5 prevents pertussis toxin-induced alterations in rat spinal cords by inhibiting increase in concentrations of spinal CSF excitatory amino acids and downregulation of glutamate transporters. 18 May 2009
• Connectivity patterns revealed by mapping of active inputs on dendrites of thalamorecipient neurons in the auditory cortex. 18 May 2009
• Peripheral inflammation increased the synaptic expression of NMDA receptors in spinal dorsal horn. 6 May 2009
• Reduced expression of the "fast" calcium transporter PMCA2a during homeostatic plasticity. May 2009
• A postnatal critical period for orientation plasticity in the cat visual cortex. 27 Apr 2009
• Inhibition of the N-methyl-d-aspartate receptor unmasks the antinociception of endogenous opioids in the periphery. 7 Apr 2009

See a longer list of these articles.

Technical information about '2-Amino-5-phosphonovalerate'

Definition: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Chemical name: Norvaline, 5-phosphono-

Registry Number: 76726-92-6

Descriptor UI: D015763

Alternative terms: 2-Amino-5-phosphonovalerate; 2 Amino 5 phosphonovalerate; 5-Phosphononorvaline; 5 Phosphononorvaline; 2-Amino-5-phosphonovaleric Acid; 2 Amino 5 phosphonovaleric Acid; 2-APV; 2-Amino-5-phosphonopentanoate; 2 Amino 5 phosphonopentanoate; 2-Amino-5-phosphonopentanoic Acid; 2 Amino 5 phosphonopentanoic Acid; dl-APV; d-APV;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Excitatory Amino Acid Antagonists;

Tree Number: D12.125.070.950.100; D12.125.740.025;

History Note: 90