5,6-Dihydroxytryptamine - Analogs & derivatives
Research News and Information

Monday, November 23, 2009

Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex.

4 May 2009 Prefrontal cortex (PFC) is critical for self-ordered response sequencing. Patients with frontal lobe damage are impaired on response sequencing tasks, and increased blood flow has been reported in ventrolateral and dorsolateral PFC in subjects ... Read more...

Elimination of serotonergic cells induces a marked increase in generation of dopaminergic neurons from mesencephalic precursors.

29 Sep 2003 Production of dopaminergic (DA) neurons from stem/precursor cells for transplantation in Parkinson's disease has become a major focus of research. However, the inductive signals mediating the production of DA neurons remain poorly understood, and ... Read more...

Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats.

31 Aug 2003 RATIONALE: Psychomotor stimulant drugs such as methylphenidate and amphetamine decrease impulsive behaviour in attention deficit hyperactivity disorder patients by unknown mechanisms. Although most behavioural effects of amphetamine are attributed ... Read more...

Latest indexed articles for '5,6-Dihydroxytryptamine - Analogs & derivatives'

These are the very latest articles for this heading:

• Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex. 4 May 2009
• Elimination of serotonergic cells induces a marked increase in generation of dopaminergic neurons from mesencephalic precursors. 29 Sep 2003
• Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats. 31 Aug 2003
• Dependence of serotonin release in the locus coeruleus on dorsal raphe neuronal activity. 29 Apr 1999
• Nucleus reticularis gigantocellularis and nucleus raphe magnus in the brain stem exert opposite effects on behavioral hyperalgesia and spinal Fos protein expression after peripheral inflammation. 27 Feb 1999
• Mass spectrometric study of 5,6- and 5,7-dihydroxytryptamines and their biological precursors. 30 Dec 1995
• Characterization of opioid receptor-mediated regulation of incertohypothalamic dopamine neurons: lack of evidence for a role of 5-hydroxytryptaminergic neurons in mediating the stimulatory effects of morphine. 16 Sep 1992
• Synthesis and biological evaluation of 4-fluoro-, 7-fluoro-, and 4,7-difluoro-5,6-dihydroxytryptamines. 30 Jul 1990
• Molecular mechanism of action of 5,6-dihydroxytryptamine. Synthesis and biological evaluation of 4-methyl-, 7-methyl-, and 4,7-dimethyl-5,6-dihydroxytryptamines. 30 Aug 1985
• Comparative effects of 5,6-dihydroxytryptamine and its benzo[b]-thiophene analogue on biogenic amines in the rat. 13 Nov 1979
• Structure-activity relationships in compounds analogous to 5,6-dihydroxytryptamine. 10 Jun 1978
• The neurotoxicity of 5,7-dihydroxytryptamine in the mouse atrium: protection by 1-phenyl-3-(2-thiazolyl)-2-thiourea and by ethanol. 30 May 1977
• Detection of a soluble serotonin-binding protein in the mammalian myenteric plexus and other peripheral sites of serotonin storage. 30 Jan 1977
• Central dopaminergic and serotoninergic systems in the regulation of adrenal tyrosine hydroxylase. 30 Dec 1976
• Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain. 30 Jan 1975
• Regeneration of the bulbospinal serotonin system after 5,6- or 5,7-dihydroxytryptamine in the rat. 30 Dec 1974

See a longer list of these articles.

Technical information about '5,6-Dihydroxytryptamine'

Definition: Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.

Chemical name: 1H-Indole-5,6-diol, 3-(2-aminoethyl)-

Registry Number: 5090-36-8

Descriptor UI: D015115

Alternative terms: 5,6-Dihydroxytryptamine; 5,6 Dihydroxytryptamine; 3-(2-Aminoethyl)indole-5,6-diol;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Serotonin Agents;

Tree Number: D03.438.473.914.201.259;

History Note: 78(75); was see under TRYPTAMINES 1975-77