5,6-Dihydroxytryptamine - Toxicity
Research News and Information

Sunday, November 22, 2009

Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex.

4 May 2009 Prefrontal cortex (PFC) is critical for self-ordered response sequencing. Patients with frontal lobe damage are impaired on response sequencing tasks, and increased blood flow has been reported in ventrolateral and dorsolateral PFC in subjects ... Read more...

Amphetamine and mCPP effects on dopamine and serotonin striatal in vivo microdialysates in an animal model of hyperactivity.

30 Jan 2007 In the neonatally 6-hydroxydopamine (6-OHDA)-lesioned rat hyperlocomotor activity, first described in the 1970s, was subsequently found to be increased by an additional lesion with 5,7-dihydroxytryptamine (5,7-DHT) (i.c.v.) in adulthood. The latter ... Read more...

Opposite morphological responses of partially denervated cortical serotonergic and noradrenergic axons to repeated stress in adult rats.

28 Jul 2004 We examined plastic changes in serotonin (5-HT) axons following repeated stress in the adult rat brain, and compared stress-induced changes between 5-HT and noradrenaline (NA) axons. We locally injected the specific neurotoxin to 5-HT axons or to NA ... Read more...

Latest indexed articles for '5,6-Dihydroxytryptamine - Toxicity'

These are the very latest articles for this heading:

• Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex. 4 May 2009
• Amphetamine and mCPP effects on dopamine and serotonin striatal in vivo microdialysates in an animal model of hyperactivity. 30 Jan 2007
• Opposite morphological responses of partially denervated cortical serotonergic and noradrenergic axons to repeated stress in adult rats. 28 Jul 2004
• The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury. 29 Jun 2004
• Interaction between serotonergic and noradrenergic axons during axonal regeneration. 30 Oct 2003
• Nucleus reticularis gigantocellularis and nucleus raphe magnus in the brain stem exert opposite effects on behavioral hyperalgesia and spinal Fos protein expression after peripheral inflammation. 27 Feb 1999
• Neurotoxicity of free-radical-mediated serotonin neurotoxin in cultured embryonic chick brain neurons. 4 May 1996
• Regeneration of serotonergic immunoreactive fibers in the brain of 5,6-dihydroxytryptamine treated rat. 30 Dec 1993
• Intestinal motility changes in rats after enteric serotonergic neuron destruction. 30 Jan 1991
• Evidence for a neural source of acute accumulation of serotonin in platelets in the injured spinal cord of rats. An experimental study using 5,6-dihydroxytryptamine treatment. 30 Dec 1990
• Veratramine-induced behavior associated with serotonergic hyperfunction in mice. 30 Dec 1990
• Oxidation of 5-hydroxytryptamine and 5,7-dihydroxytryptamine. A new oxidation pathway and formation of a novel neurotoxin. 30 Mar 1986
• Dihydroxytryptamines as tools to study the neurobiology of serotonin. 29 Jun 1982
• Morphological changes produced by drugs acting on the autonomic nervous system. 30 Dec 1978
• Actions of drugs that deplete serotonin. 29 Jun 1977
• Cardiovascular toxicity of dihydroxytryptamines. 29 Apr 1976

See a longer list of these articles.

Technical information about '5,6-Dihydroxytryptamine'

Definition: Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.

Chemical name: 1H-Indole-5,6-diol, 3-(2-aminoethyl)-

Registry Number: 5090-36-8

Descriptor UI: D015115

Alternative terms: 5,6-Dihydroxytryptamine; 5,6 Dihydroxytryptamine; 3-(2-Aminoethyl)indole-5,6-diol;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Serotonin Agents;

Tree Number: D03.438.473.914.201.259;

History Note: 78(75); was see under TRYPTAMINES 1975-77