5,6-Dihydroxytryptamine
Research News and Information

Sunday, November 22, 2009

Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex.

4 May 2009 Prefrontal cortex (PFC) is critical for self-ordered response sequencing. Patients with frontal lobe damage are impaired on response sequencing tasks, and increased blood flow has been reported in ventrolateral and dorsolateral PFC in subjects ... Read more...

Amphetamine and mCPP effects on dopamine and serotonin striatal in vivo microdialysates in an animal model of hyperactivity.

30 Jan 2007 In the neonatally 6-hydroxydopamine (6-OHDA)-lesioned rat hyperlocomotor activity, first described in the 1970s, was subsequently found to be increased by an additional lesion with 5,7-dihydroxytryptamine (5,7-DHT) (i.c.v.) in adulthood. The latter ... Read more...

Comparative studies of the effects of chlorpromazine and 5,6-dihydroxytryptamine on locomotion, defensive reactions in the snail Helix lucorum, and command neuron excitability in long-term sensitization.

30 Aug 2006 The actions of the neuroleptic chlorpromazine (CPZ) and the neurotoxin 5,6-dihydroxytryptamine (5,6-DHT) on defensive reactions, locomotion, formation of long-term sensitization, and the electrical characteristics of command neurons in the common ... Read more...

Latest indexed articles for '5,6-Dihydroxytryptamine'

These are the very latest articles for this heading:

• Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex. 4 May 2009
• Amphetamine and mCPP effects on dopamine and serotonin striatal in vivo microdialysates in an animal model of hyperactivity. 30 Jan 2007
• Comparative studies of the effects of chlorpromazine and 5,6-dihydroxytryptamine on locomotion, defensive reactions in the snail Helix lucorum, and command neuron excitability in long-term sensitization. 30 Aug 2006
• Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes. 24 Aug 2005
• [Comparative investigation of influence of injections of chlorpromazine and 5,6-dihydroxytryptamine on locomotion, defensive reactions of snall helix lucorum and excitability of command neurons in long-term sensitization] 29 Jun 2005
• Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. 30 Dec 2004
• Opposite morphological responses of partially denervated cortical serotonergic and noradrenergic axons to repeated stress in adult rats. 28 Jul 2004
• The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury. 29 Jun 2004
• Interaction between serotonergic and noradrenergic axons during axonal regeneration. 30 Oct 2003
• Elimination of serotonergic cells induces a marked increase in generation of dopaminergic neurons from mesencephalic precursors. 29 Sep 2003
• Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats. 31 Aug 2003
• Electrophysiological studies of the effects of 5,6-dihydroxytryptamine on the acquisition of a conditioned defensive reflex in snails. 29 Jun 2003
• Comparative effects of injecting 5,6-dihydroxytryptamine in the dorsal or medial raphe nuclei on rat puberty. 13 May 2003
• 7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors. 13 Jun 2002
• Monoamine neurotoxins-induced apoptosis in lymphocytes by a common oxidative stress mechanism: involvement of hydrogen peroxide (H(2)O(2)), caspase-3, and nuclear factor kappa-B (NF-kappaB), p53, c-Jun transcription factors. 13 Feb 2002
• [Electrophysiological study of 5,6-dihydroxytryptamine effect on defensive reflex conditioning in the snail] 30 Jan 2002
• Serotonin modulates expression of VIP and GRP mRNA via the 5-HT(1B) receptor in the suprachiasmatic nucleus of the rat. 29 Sep 2001
• Differential effects of (R)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats. 2 Jun 1999
• Dependence of serotonin release in the locus coeruleus on dorsal raphe neuronal activity. 29 Apr 1999
• Nucleus reticularis gigantocellularis and nucleus raphe magnus in the brain stem exert opposite effects on behavioral hyperalgesia and spinal Fos protein expression after peripheral inflammation. 27 Feb 1999

See a longer list of these articles.

Technical information about '5,6-Dihydroxytryptamine'

Definition: Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.

Chemical name: 1H-Indole-5,6-diol, 3-(2-aminoethyl)-

Registry Number: 5090-36-8

Descriptor UI: D015115

Alternative terms: 5,6-Dihydroxytryptamine; 5,6 Dihydroxytryptamine; 3-(2-Aminoethyl)indole-5,6-diol;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Serotonin Agents;

Tree Number: D03.438.473.914.201.259;

History Note: 78(75); was see under TRYPTAMINES 1975-77