5-Hydroxytryptophan
Research News and Information

Sunday, November 22, 2009

99mTc-DTPA-amino acids conjugate as specific SPECT pharmaceuticals for tumor imaging.

30 Jul 2009 (99m)Tc-Diethylene triamine pentaacetic acid-bis (amide) conjugates have been synthesized and evaluated as a potential radiopharmaceutical for tumor imaging. The compounds were synthesized by the condensation reaction of DTPA bis(anhydride) with ... Read more...

Glycosylated hydroxytryptophan in a mussel adhesive protein from Perna viridis.

5 Jul 2009 The 3,4-dihydroxyphenyl-l-alanine (Dopa)-containing proteins of mussel byssus play a critical role in wet adhesion and have inspired versatile new synthetic strategies for adhesives and coatings. Apparently, however, not all mussel adhesive proteins ... Read more...

Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome.

18 May 2009 Serotonin (5-hydroxytryptamine; 5-HT)-toxicity syndrome, an iatrogenic brain disorder induced by excessive efflux of 5-HT, has received much attention because of increasing incidents of serotonergic antidepressants. However, the neural mechanism by ... Read more...

Latest indexed articles for '5-Hydroxytryptophan'

These are the very latest articles for this heading:

• 99mTc-DTPA-amino acids conjugate as specific SPECT pharmaceuticals for tumor imaging. 30 Jul 2009
• Glycosylated hydroxytryptophan in a mussel adhesive protein from Perna viridis. 5 Jul 2009
• Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome. 18 May 2009
• Meal ingestion, amino acids and brain neurotransmitters: effects of dietary protein source on serotonin and catecholamine synthesis rates. 16 May 2009
• The effect of increased serotonergic neurotransmission on aggression: a critical meta-analytical review of preclinical studies. 28 Apr 2009
• Characterization of pu-erh tea using chemical and metabolic profiling approaches. 20 Apr 2009
• Serotonin, social status and sex change in the bluebanded goby Lythrypnus dalli. 31 Mar 2009
• Estrogen rapidly modulates 5-hydroxytrytophan-induced visceral hypersensitivity via GPR30 in rats. 30 Mar 2009
• Proton speciation and microspeciation of serotonin and 5-hydroxytryptophan. 30 Mar 2009
• 5-hydroxytryptophan acts on the mitogen-activated protein kinase extracellular-signal regulated protein kinase pathway to modulate cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 cells. 30 Mar 2009
• How physician obesity specialists use drugs to treat obesity. 17 Mar 2009
• Acoustic stimulation in vivo and corticotropin-releasing factor in vitro increase tryptophan hydroxylase activity in the rat caudal dorsal raphe nucleus. 12 Mar 2009
• Direct and decarboxylation-dependent effects of neurotransmitter precursors on firing of isolated monoaminergic neurons. 8 Mar 2009
• 1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT(2A) receptors: proposal of a modified rodent antidepressant assay. 4 Mar 2009
• [Naloxone-induced suppression of the behavioral manifestation of serotoninergic system hyperactivation by beta-casomorphins-7 in mice] 27 Feb 2009
• Development of novel mass spectrometric methods for identifying HOCl-induced modifications to proteins. 27 Feb 2009
• Serotonin mediates behavioral gregarization underlying swarm formation in desert locusts. 28 Jan 2009
• Elevated plasma chromogranin A is the first indication of recurrence in radically operated midgut carcinoid tumors. 27 Jan 2009
• Reproductive responses and nitric oxide activity in Japanese quail, Coturnix coturnix japonica, are altered by specific phase relationships of neural (serotonergic and dopaminergic) oscillations and pineal function. 21 Jan 2009
• Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms. 18 Jan 2009

See a longer list of these articles.

Technical information about '5-Hydroxytryptophan'

Definition: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.

Chemical name: 2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Registry Number: 56-69-9

Descriptor UI: D006916

Alternative terms: 5-Hydroxytryptophan; 5 Hydroxytryptophan; Tryptophan, 5-Hydroxy-; 5-Hydroxy- Tryptophan; Tryptophan, 5 Hydroxy; Oxytryptophan; 5-HTP; Oxitriptan; Hydroxytryptophan;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antidepressive Agents, Second-Generation;

Tree Number: D12.125.072.050.850.479;

Online Note: use 5-HYDROXYTRYPTOPHAN to search HYDROXYTRYPTOPHAN 1966-89

History Note: 90; was HYDROXYTRYPTOPHAN 1963-89 (Prov 1963-65)