8-Hydroxy-2-(di-n-propylamino)tetralin
Research News and Information

Monday, November 23, 2009

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.

18 Sep 2009 After complete spinal cord transections that removed all supraspinal inputs in adult rats, combinations of serotonergic agonists and epidural electrical stimulation were able to acutely transform spinal networks from nonfunctional to highly ... Read more...

The potency of different serotonergic agonists in counteracting opioid evoked cardiorespiratory disturbances.

10 Sep 2009 Serotonin receptor (5-HTR) agonists that target 5-HT(4(a))R and 5-HT(1A)R can reverse mu-opioid receptor (mu-OR)-evoked respiratory depression. Here, we have tested whether such rescuing by serotonin agonists also applies to the cardiovascular ... Read more...

Serotonin targets inhibitory synapses to induce modulation of network functions.

10 Sep 2009 The cellular effects of serotonin (5-HT), a neuromodulator with widespread influences in the central nervous system, have been investigated. Despite detailed knowledge about the molecular biology of cellular signalling, it is not possible to ... Read more...

Latest indexed articles for '8-Hydroxy-2-(di-n-propylamino)tetralin'

These are the very latest articles for this heading:

• Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. 18 Sep 2009
• The potency of different serotonergic agonists in counteracting opioid evoked cardiorespiratory disturbances. 10 Sep 2009
• Serotonin targets inhibitory synapses to induce modulation of network functions. 10 Sep 2009
• Role of spinal serotonergic pathways in sneeze-induced urethral continence reflex in rats. 27 Jul 2009
• Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice. 17 Jul 2009
• Mutant 5-hydroxytryptamine 1A receptor D116A is a receptor activated solely by synthetic ligands with a rich pharmacology. 13 Jul 2009
• Attenuation of somatodendritic responses to 8-hydroxy-2-di-npropylamino tetralin following long-term dietary sugar consumption in rats. 29 Jun 2009
• Neurosteroids modulate compulsive and persistent behavior in rodents: implications for obsessive-compulsive disorder. 19 Jun 2009
• Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task. 15 Jun 2009
• The contribution of serotonin 1A receptors to kappa opioid immunosuppression. 9 Jun 2009
• Inhibition of the cardiovascular response to stress by systemic 5-HT1A activation: sympathoinhibition or anxiolysis? 8 Jun 2009
• PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. Jun 2009
• Early postnatal stress affects 5-HT1A receptor function in the medial prefrontal cortex in adult rats. 22 May 2009
• Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys. 19 May 2009
• Serotonergic mechanisms of the median raphe nucleus-dorsal hippocampus in conditioned fear: Output circuit involves the prefrontal cortex and amygdala. 19 May 2009
• Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats. 13 May 2009
• Apamin increases 5-HT cell firing in raphe dorsalis and extracellular 5-HT levels in amygdala: a concomitant in vivo study in anesthetized rats. 12 May 2009
• Individual differences in the sensitivity to serotonergic drugs: a pharmacobehavioural approach using rats selected on the basis of their response to novelty. 10 May 2009
• X11-like protein deficiency is associated with impaired conflict resolution in mice. 4 May 2009
• The firing activity of pyramidal neurons in medial prefrontal cortex and their response to 5-hydroxytryptamine-1A receptor stimulation in a rat model of Parkinson's disease. 2 May 2009

See a longer list of these articles.

Technical information about '8-Hydroxy-2-(di-n-propylamino)tetralin'

Definition: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.

Chemical name: 1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-

Registry Number: 78950-78-4

Descriptor UI: D017371

Alternative terms: 8-Hydroxy-2-(di-n-propylamino)tetralin; 8-OH-DPAT; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (+-)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (R)-Isomer,; 8-Hydroxy-2-(di-n-propylamino)tetralin, (S)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrochloride, (R)-Isomer,; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrochloride, (S)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin, (+-)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin, (R)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (S)-Isomer,;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Serotonin Agonists;

Tree Number: D02.455.426.559.847.638.960.400; D04.615.638.960.400;

Online Note: use 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN (NM) to search 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN 1982-92

History Note: 93; was 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN (NM) 1982-92