Abnormalities, Drug-Induced - Etiology
Research News and Information

Sunday, November 22, 2009

Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort study.

21 Sep 2009 OBJECTIVE: To investigate any association between selective serotonin reuptake inhibitors (SSRIs) taken during pregnancy and congenital major malformations. DESIGN: Population based cohort study. PARTICIPANTS: 493 113 children born in Denmark, ... Read more...

The impact of human superoxide dismutase 1 expression in a mouse model on the embryotoxicity of hydroxyurea.

30 Aug 2009 BACKGROUND: Oxidative stress is hypothesized to mediate embryotoxicity during organogenesis, yet the reactive oxygen species involved are not defined. The superoxide oxygen radical is converted to hydrogen peroxide, a less reactive species, by ... Read more...

An interspecies comparison of placental antibody transfer: new insights into developmental toxicity testing of monoclonal antibodies.

30 Jul 2009 There are profound differences in maternofetal transfer of immunoglobulins between species with extensive gestational transfer of maternal immunoglobulins in primates (including humans) via the chorioallantoic placenta as well as in rabbits and ... Read more...

Latest indexed articles for 'Abnormalities, Drug-Induced - Etiology'

These are the very latest articles for this heading:

• SSRIs and congenital defects. Spontaneous publishing and academic miscarriages (SPAM). 19 Oct 2009
• Women should give informed consent before starting SSRIs. 19 Oct 2009
• SSRIs and heart defects in neonates. 19 Oct 2009
• SSRIs and congenital defects. Case registers in pregnancy? 19 Oct 2009
• GSK is sued in US over alleged link of paroxetine to birth defects. 10 Oct 2009
• Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort study. 21 Sep 2009
• Selective serotonin reuptake inhibitors and congenital malformations. 21 Sep 2009
• The impact of human superoxide dismutase 1 expression in a mouse model on the embryotoxicity of hydroxyurea. 30 Aug 2009
• An interspecies comparison of placental antibody transfer: new insights into developmental toxicity testing of monoclonal antibodies. 30 Jul 2009
• Atypical antipsychotic (clozapine) self-poisoning in late pregnancy presenting with absent fetal heart rate variability without acidosis and delayed peristalsis in the newborn baby: a case report. 30 Jul 2009
• Isolated corneal opacification and microphthalmia: a suspected warfarin embryopathy. 30 Jul 2009
• Maternal use of oral contraceptives during early pregnancy and risk of hypospadias in male offspring. 7 Jul 2009
• Safety of topical corticosteroids in pregnancy. 6 Jul 2009
• Maternal occupational exposure to solvents and congenital malformations: a prospective study in the general population. 29 Jun 2009
• Medications in pregnancy and lactation. 29 Jun 2009
• Managing depression during pregnancy. 29 Jun 2009
• A case of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug. 21 Jun 2009
• The safety of metoclopramide use in the first trimester of pregnancy. 9 Jun 2009
• Clinicians' knowledge of 2007 Food and Drug Administration recommendation to discontinue nelfinavir use during pregnancy. 6 Jun 2009
• [Pollen allergy and pregnancy. A literature review of anti-allergic agents shows no increased risk of fetal injuries] 30 May 2009

See a longer list of these articles.

Technical information about 'Abnormalities, Drug-Induced'

Definition: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Descriptor UI: D000014

Alternative terms: Abnormalities, Drug-Induced; Abnormalities, Drug Induced; Drug-Induced Abnormalities; Abnormality, Drug-Induced; Drug Induced Abnormalities; Drug-Induced Abnormality;

Related Mesh Headings: Teratogens;

Allowable Qualifiers: blood; cerebrospinal fluid; classification; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; ultrastructure; urine; veterinary; ultrasonography; virology;

Tree Number: C16.131.042;

History Note: 64

Technical Notes: IM; do not use /chem ind /compl /congen & do not coord with INFANT, NEWBORN, DISEASES; coord IM with specific chem /adv eff-pois-tox (IM) + specific organ /abnorm or specific abnorm /chem ind (IM); Manual 23.20.3