Acetylcholine - Metabolism
Research News and Information

Saturday, November 21, 2009

Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholinergic control of nociception revealed using siRNA in rats.

21 Sep 2009 Muscarinic acetylcholine receptors (mAChRs) are involved in the control of nociception in the spinal cord. The M(2), M(3), and M(4) mAChR subtypes are present in the spinal dorsal horn. However, the role of the individual subtypes in the ... Read more...

Discharge profiles of identified GABAergic in comparison to cholinergic and putative glutamatergic basal forebrain neurons across the sleep-wake cycle.

21 Sep 2009 Whereas basal forebrain (BF) cholinergic neurons are known to participate in processes of cortical activation during wake (W) and paradoxical sleep (PS or P, also called REM sleep), codistributed GABAergic neurons have been thought to participate in ... Read more...

Dopamine modulation of the in vivo acetylcholine response in the Drosophila mushroom body.

13 Sep 2009 Olfactory sensory information in Drosophila is transmitted through antennal lobe projections to Mushroom Body neurons (Kenyon cells) by means of cholinergic synapses. Application of acetylcholine (ACh) and odors produce significant increases in ... Read more...

Latest indexed articles for 'Acetylcholine - Metabolism'

These are the very latest articles for this heading:

• Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholinergic control of nociception revealed using siRNA in rats. 21 Sep 2009
• Discharge profiles of identified GABAergic in comparison to cholinergic and putative glutamatergic basal forebrain neurons across the sleep-wake cycle. 21 Sep 2009
• Dopamine modulation of the in vivo acetylcholine response in the Drosophila mushroom body. 13 Sep 2009
• Activation of nicotinic acetylcholine receptors enhances a slow calcium-dependent potassium conductance and reduces the firing of stratum oriens interneurons. 2 Sep 2009
• The relationship between nicotinic receptors and cognitive functioning in healthy aging: An in vivo positron emission tomography (PET) study with 2-[(18)F]fluoro-A-85380. 30 Aug 2009
• Unraveling smooth muscle contraction: the TRP link. 26 Aug 2009
• Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. 18 Aug 2009
• Enzymatic activity versus structural dynamics: the case of acetylcholinesterase tetramer. 3 Aug 2009
• Synchronization of pancreatic islet oscillations by intrapancreatic ganglia: a modeling study. 3 Aug 2009
• Weak toxin WTX from Naja kaouthia cobra venom interacts with both nicotinic and muscarinic acetylcholine receptors. 2 Aug 2009
• Neurotransmitter receptor imbalances in motor cortex and basal ganglia in hepatic encephalopathy. Aug 2009
• Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension. 30 Jul 2009
• Protective effects of Wu-Zi-Yan-Zong-Fang on amyloid beta-induced damage in vivo and in vitro. 30 Jul 2009
• Role of acetylcholine in negative patterning in turtles (Chrysemys picta). 30 Jul 2009
• Effects of scopolamine on dopamine neurons in the substantia nigra: role of the pedunculopontine tegmental nucleus. 30 Jul 2009
• The vesicular acetylcholine transporter is required for neuromuscular development and function. 25 Jul 2009
• Selective potentiation of crossed vs. uncrossed inputs from lateral geniculate nucleus to visual cortex by the basal forebrain: potential facilitation of rodent binocularity. 21 Jul 2009
• Decreased nitric oxide bioavailability in a mouse model of Fabry disease. 21 Jul 2009
• [(3)H]Epibatidine photolabels non-equivalent amino acids in the agonist binding site of Torpedo and alpha4beta2 nicotinic acetylcholine receptors. 18 Jul 2009
• High K+-induced contraction requires depolarization-induced Ca2+ release from internal stores in rat gut smooth muscle. 4 Jul 2009

See a longer list of these articles.

Technical information about 'Acetylcholine'

Definition: A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.

Chemical name: Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-

Registry Number: 51-84-3

Descriptor UI: D000109

Alternative terms: Acetylcholine; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; Acetylcholine Bromide; Bromide, Acetylcholine; Bromoacetylcholine; Acetylcholine Chloride; Chloroacetylcholine; Acetylcholine Fluoride; Fluoride, Acetylcholine; Acetylcholine Hydroxide; Hydroxide, Acetylcholine; Acetylcholine L-Tartrate; Acetylcholine L Tartrate; L-Tartrate, Acetylcholine; Acetylcholine Perchlorate; Perchlorate, Acetylcholine; Acetylcholine Picrate (1:1); Acetylcholine Picrate; Acetylcholine Sulfate (1:1); Miochol; Ciba Vision Brand of Acetylcholine Chloride; Iolab Brand of Acetylcholine Chloride; Bournonville Brand of Acetylcholine Chloride; Acetilcolina Cusi; Cusi, Acetilcolina; Alcon Brand of Acetylcholine Chloride; Acetylcholine Iodide; Iodide, Acetylcholine;

Related Mesh Headings: Receptors, Cholinergic;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Cholinergic Agents; Vasodilator Agents;

Tree Number: D02.092.211.111;

History Note: 1998; for MIOCHOL use ACETYLCHOLINE (NM) 1981-1997; for CHLOROACETYLCHOLINE use ACETYLCHOLINE (NM) 1969-2000; for BROMOACETYLCHOLINE use ACETYLCHOLINE (NM) 1969-2000

Technical Notes: /biosyn /physiol permitted