Acetylcholine
Research News and Information

Saturday, November 21, 2009

Precise subcellular input retinotopy and its computational consequences in an identified visual interneuron.

22 Sep 2009 The Lobula Giant Movement Detector (LGMD) is a higher-order visual interneuron of Orthopteran insects that responds preferentially to objects approaching on a collision course. It receives excitatory input from an entire visual hemifield that ... Read more...

Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholinergic control of nociception revealed using siRNA in rats.

21 Sep 2009 Muscarinic acetylcholine receptors (mAChRs) are involved in the control of nociception in the spinal cord. The M(2), M(3), and M(4) mAChR subtypes are present in the spinal dorsal horn. However, the role of the individual subtypes in the ... Read more...

Discharge profiles of identified GABAergic in comparison to cholinergic and putative glutamatergic basal forebrain neurons across the sleep-wake cycle.

21 Sep 2009 Whereas basal forebrain (BF) cholinergic neurons are known to participate in processes of cortical activation during wake (W) and paradoxical sleep (PS or P, also called REM sleep), codistributed GABAergic neurons have been thought to participate in ... Read more...

Latest indexed articles for 'Acetylcholine'

These are the very latest articles for this heading:

• Precise subcellular input retinotopy and its computational consequences in an identified visual interneuron. 22 Sep 2009
• Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholinergic control of nociception revealed using siRNA in rats. 21 Sep 2009
• Discharge profiles of identified GABAergic in comparison to cholinergic and putative glutamatergic basal forebrain neurons across the sleep-wake cycle. 21 Sep 2009
• eNOS uncoupling and endothelial dysfunction in aged vessels. 16 Sep 2009
• Dopamine modulation of the in vivo acetylcholine response in the Drosophila mushroom body. 13 Sep 2009
• Absence of adenosine-mediated aortic relaxation in A(2A) adenosine receptor knockout mice. 9 Sep 2009
• Long-term portal hypertension increases the vasodilator response to acetylcholine in rat aorta: role of prostaglandin I2. 5 Sep 2009
• Activation of nicotinic acetylcholine receptors enhances a slow calcium-dependent potassium conductance and reduces the firing of stratum oriens interneurons. 2 Sep 2009
• Detection of endogenous acetylcholine release during brief ischemia in the rabbit ventricle: a possible trigger for ischemic preconditioning. 31 Aug 2009
• Synthesis of a quaternary bis derivative of imipramine as a novel compound with potential anti-enuretic effect. 30 Aug 2009
• The relationship between nicotinic receptors and cognitive functioning in healthy aging: An in vivo positron emission tomography (PET) study with 2-[(18)F]fluoro-A-85380. 30 Aug 2009
• Adjunct nitrous oxide normalizes vascular reactivity changes after hemorrhagic shock in mice under isoflurane anesthesia. 30 Aug 2009
• Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. 30 Aug 2009
• Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats. 26 Aug 2009
• Unraveling smooth muscle contraction: the TRP link. 26 Aug 2009
• Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor. 25 Aug 2009
• Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. 18 Aug 2009
• Upregulation of matrix metalloproteinase-2 in the arterial vasculature contributes to stiffening and vasomotor dysfunction in patients with chronic kidney disease. 15 Aug 2009
• Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE. 10 Aug 2009
• Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production. 5 Aug 2009

See a longer list of these articles.

Technical information about 'Acetylcholine'

Definition: A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.

Chemical name: Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-

Registry Number: 51-84-3

Descriptor UI: D000109

Alternative terms: Acetylcholine; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; Acetylcholine Bromide; Bromide, Acetylcholine; Bromoacetylcholine; Acetylcholine Chloride; Chloroacetylcholine; Acetylcholine Fluoride; Fluoride, Acetylcholine; Acetylcholine Hydroxide; Hydroxide, Acetylcholine; Acetylcholine L-Tartrate; Acetylcholine L Tartrate; L-Tartrate, Acetylcholine; Acetylcholine Perchlorate; Perchlorate, Acetylcholine; Acetylcholine Picrate (1:1); Acetylcholine Picrate; Acetylcholine Sulfate (1:1); Miochol; Ciba Vision Brand of Acetylcholine Chloride; Iolab Brand of Acetylcholine Chloride; Bournonville Brand of Acetylcholine Chloride; Acetilcolina Cusi; Cusi, Acetilcolina; Alcon Brand of Acetylcholine Chloride; Acetylcholine Iodide; Iodide, Acetylcholine;

Related Mesh Headings: Receptors, Cholinergic;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Cholinergic Agents; Vasodilator Agents;

Tree Number: D02.092.211.111;

History Note: 1998; for MIOCHOL use ACETYLCHOLINE (NM) 1981-1997; for CHLOROACETYLCHOLINE use ACETYLCHOLINE (NM) 1969-2000; for BROMOACETYLCHOLINE use ACETYLCHOLINE (NM) 1969-2000

Technical Notes: /biosyn /physiol permitted