Acetylcholinesterase - Metabolism
Research News and Information

Saturday, November 21, 2009

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

8 Sep 2009 Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) aggregation, and ... Read more...

A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening.

Sep 2009 By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and ... Read more...

Acetylcholinesterase and HHV-8 in squamous cell carcinoma and retinoblastoma.

30 Aug 2009 Acetylcholinesterase (AChE) and human herpesvirus type 8 (HHV-8) antigens were studied in tissue sections from 56 squamous cell carcinomas (SCC) and five retinoblastomas (Rb). Approximately 62.5% of SCC and 80% of Rb showed positive staining for ... Read more...

Latest indexed articles for 'Acetylcholinesterase - Metabolism'

These are the very latest articles for this heading:

• Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. 8 Sep 2009
• A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening. Sep 2009
• Acetylcholinesterase and HHV-8 in squamous cell carcinoma and retinoblastoma. 30 Aug 2009
• The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. 24 Aug 2009
• The toxic effects of ionic liquids on the activities of acetylcholinesterase and cellulase in earthworms. 11 Aug 2009
• A multibiomarker approach in Mytilus galloprovincialis to assess environmental quality. 5 Aug 2009
• Enzymatic activity versus structural dynamics: the case of acetylcholinesterase tetramer. 3 Aug 2009
• Protective effects of Wu-Zi-Yan-Zong-Fang on amyloid beta-induced damage in vivo and in vitro. 30 Jul 2009
• Individual differences in skilled reaching for food related to increased number of gestures: evidence for goal and habit learning of skilled reaching. 30 Jul 2009
• Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin. 30 Jul 2009
• Biochemical and proteomic effects in Procambarus clarkii after chlorpyrifos or carbaryl exposure under sublethal conditions. 30 Jul 2009
• Unusual transfer of CutA into the secretory pathway, evidenced by fusion proteins with acetylcholinesterase. 21 Jul 2009
• Fixation of the two Tabun isomers in acetylcholinesterase: a QM/MM study. 21 Jul 2009
• Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy. 21 Jul 2009
• Acute effects of copper and mercury on the estuarine fish Pomatoschistus microps: linking biomarkers to behaviour. 20 Jul 2009
• Comparing the inhibitory effects of five protoxicant organophosphates (azinphos-methyl, parathion-methyl, chlorpyriphos-methyl, methamidophos and diazinon) on the spontaneously beating auricle of Sparus aurata: an in vitro study. 14 Jul 2009
• Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiae. 12 Jul 2009
• The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain. 12 Jul 2009
• Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors. 4 Jul 2009
• In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Acetylcholinesterase'

Definition: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.

Chemical name: Acetylcholine acetylhydrolase

Registry Number: EC 3.1.1.7

Descriptor UI: D000110

Alternative terms: Acetylcholinesterase; Acetylcholine Hydrolase; Hydrolase, Acetylcholine; Acetylthiocholinesterase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.352.100.170.176;

Technical Notes: reactivation or reactivators: coord NIM (with no qualif) with CHOLINESTERASE REACTIVATORS (IM)