Acetylcholinesterase
Research News and Information

Saturday, November 21, 2009

Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats.

Oct 2009 AIMS: Chronic hyperglycaemia in diabetes involves a direct neuronal damage caused by intracellular glucose which leads to altered neurotransmitter functions and reduced motor activity. The present study investigated the effect of curcumin in the ... Read more...

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

8 Sep 2009 Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) aggregation, and ... Read more...

A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening.

Sep 2009 By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and ... Read more...

Latest indexed articles for 'Acetylcholinesterase'

These are the very latest articles for this heading:

• Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats. Oct 2009
• Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. 8 Sep 2009
• A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening. Sep 2009
• Acetylcholinesterase and HHV-8 in squamous cell carcinoma and retinoblastoma. 30 Aug 2009
• Retrospective population pharmacokinetic/pharmacodynamic analysis of pyridostigmine, a cholinesterase inhibitor, in Chinese males. 30 Aug 2009
• Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness. 30 Aug 2009
• Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships. 30 Aug 2009
• The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. 24 Aug 2009
• An evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon. 17 Aug 2009
• The toxic effects of ionic liquids on the activities of acetylcholinesterase and cellulase in earthworms. 11 Aug 2009
• A multibiomarker approach in Mytilus galloprovincialis to assess environmental quality. 5 Aug 2009
• Enzymatic activity versus structural dynamics: the case of acetylcholinesterase tetramer. 3 Aug 2009
• [Molecular bases and therapeutic strategies in defective neuromuscular transmissions: lessons learned from a prototypical synapse] 30 Jul 2009
• Protective effects of Wu-Zi-Yan-Zong-Fang on amyloid beta-induced damage in vivo and in vitro. 30 Jul 2009
• Individual differences in skilled reaching for food related to increased number of gestures: evidence for goal and habit learning of skilled reaching. 30 Jul 2009
• Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin. 30 Jul 2009
• Biochemical and proteomic effects in Procambarus clarkii after chlorpyrifos or carbaryl exposure under sublethal conditions. 30 Jul 2009
• Galantamine is a novel post-exposure therapeutic against lethal VX challenge. 28 Jul 2009
• Unusual transfer of CutA into the secretory pathway, evidenced by fusion proteins with acetylcholinesterase. 21 Jul 2009
• Fixation of the two Tabun isomers in acetylcholinesterase: a QM/MM study. 21 Jul 2009

See a longer list of these articles.

Technical information about 'Acetylcholinesterase'

Definition: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.

Chemical name: Acetylcholine acetylhydrolase

Registry Number: EC 3.1.1.7

Descriptor UI: D000110

Alternative terms: Acetylcholinesterase; Acetylcholine Hydrolase; Hydrolase, Acetylcholine; Acetylthiocholinesterase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.352.100.170.176;

Technical Notes: reactivation or reactivators: coord NIM (with no qualif) with CHOLINESTERASE REACTIVATORS (IM)