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Adaptor Proteins, Signal Transducing - Research News and Information
Wednesday, January 07, 2009
Definition of 'Adaptor Proteins, Signal Transducing'A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes Common names: Adaptor Proteins, Signal Transducing; Signal Transducing Adaptor Proteins |
29 Nov 2008 
Despite our growing insight into carcinogenesis, treatment of tumors, especially nonsmall cell lung cancer (NSCLC), remains limited and it is urgent to develop strategies that target tumor cells and their genetic features. Drug discovery efforts ... Read more...
MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer.
13 Nov 2008 Rare inherited mutations in the mutL homolog 1 (MLH1) DNA mismatch repair gene can confer an increased susceptibility to colorectal cancer (CRC) with high penetrance where disease frequently develops in the proximal colon. The core promoter of MLH1 ... Read more...
Regulating the conversion between rounded and elongated modes of cancer cell movement.
2 Nov 2008 Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt to varying microenvironments. In a recent issue of Cell, Sanz-Moreno et al. identify DOCK3, NEDD9, WAVE2, and ARHGAP22 as key molecules regulating Rac ... Read more...
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Latest indexed articles for 'Adaptor Proteins, Signal Transducing'
These are the very latest articles for this heading:
- Original triazine inductor of new specific molecular targets, with antitumor activity against nonsmall cell lung cancer. 29 Nov 2008
- MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer. 13 Nov 2008
- Regulating the conversion between rounded and elongated modes of cancer cell movement. 2 Nov 2008
- The BH3-only protein Bik/Blk/Nbk inhibits nuclear translocation of activated ERK1/2 to mediate IFNgamma-induced cell death. Nov 2008
- CpG island hypermethylation of E-cadherin (CDH1) and integrin alpha4 is associated with recurrence of early stage esophageal squamous cell carcinoma. 30 Oct 2008
- TRIM family proteins and their emerging roles in innate immunity. 30 Oct 2008
- MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23. 27 Oct 2008
- Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells. 25 Oct 2008
- Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing. 18 Oct 2008
- Casitas B-lineage lymphoma b inhibits antigen recognition and slows cell cycle progression at late times during CD4+ T cell clonal expansion. 13 Oct 2008
- Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1. 13 Oct 2008
- MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. 13 Oct 2008
- The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. 13 Oct 2008
- Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor. 13 Oct 2008
- Sperm-associated antigen 9 is associated with tumor growth, migration, and invasion in renal cell carcinoma. 13 Oct 2008
- Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. 13 Oct 2008
- Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. 13 Oct 2008
- Mismatch repair gene mutations in Chinese HNPCC patients. 12 Oct 2008
- Network model of survival signaling in large granular lymphocyte leukemia. 11 Oct 2008
- GluR1 controls dendrite growth through its binding partner, SAP97. 6 Oct 2008
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Technical information about 'Adaptor Proteins, Signal Transducing'
Definition: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
Registry Number: 0
Descriptor UI: D048868
Alternative terms: Adaptor Proteins, Signal Transducing; Signal Transducing Adaptor Proteins;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;
Tree Number: D12.644.360.024; D12.776.157.057; D12.776.476.024;
History Note: 2005