Adenine
Research News and Information

Sunday, November 22, 2009

Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.

6 Oct 2009 Adenine derivatives bearing substituents in the 2-, N(6)-, 7-, 8-, and/or 9-position and a series of deazapurines were synthesized and investigated in [(3)H]adenine binding studies at the adenine receptor in rat brain cortical membrane preparations ... Read more...

Further evidence for an association between mandibular height and the growth hormone receptor gene in a Japanese population.

29 Sep 2009 INTRODUCTION: Craniofacial morphology has a significant genetic component. It has recently been reported that single nucleotide polymorphisms (SNPs) in the growth hormone receptor gene (GHR) are associated with mandibular height. To confirm these ... Read more...

Efficacy of entecavir in patients with chronic hepatitis B resistant to both lamivudine and adefovir or to lamivudine alone.

29 Sep 2009 Entecavir (ETV) is currently recommended as a rescue therapy purely for adefovir (ADV)-resistant chronic hepatitis B virus (HBV) infections. We evaluated the efficacy of ETV in patients who were resistant to lamivudine (LAM)/ADV sequential therapy ... Read more...

Latest indexed articles for 'Adenine'

These are the very latest articles for this heading:

• Tenofovir coadministration is not associated with lower unboosted atazanavir plasma exposure in the clinical setting. 30 Oct 2009
• Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. 6 Oct 2009
• Further evidence for an association between mandibular height and the growth hormone receptor gene in a Japanese population. 29 Sep 2009
• Efficacy of entecavir in patients with chronic hepatitis B resistant to both lamivudine and adefovir or to lamivudine alone. 29 Sep 2009
• Conserved T cell and natural killer cell function in treatment-experienced adults receiving tenofovir plus didanosine as nucleoside reverse transcription inhibitor backbone. 29 Sep 2009
• [Tenofovir, An antiviral agent with activity against HIV infections and hepatitis B.] 30 Aug 2009
• Interactions of the "piano-stool" [ruthenium(II) (eta6-arene)(en)CL]+ complexes with water and nucleobases; ab initio and DFT study. 30 Aug 2009
• Postischemic treatment of neonatal cerebral ischemia should target autophagy. 30 Aug 2009
• Virological response to initial antiretroviral regimens containing abacavir or tenofovir. 30 Aug 2009
• Dynamic changes of HBV quasispecies and deletion patterns in a chronic hepatitis B patient. 30 Aug 2009
• Chronic hepatitis B: update 2009. 30 Aug 2009
• Renal dysfunction in chronic hepatitis B patients treated with adefovir dipivoxil. 30 Aug 2009
• Blockage of A2A and A3 adenosine receptors decreases the desensitization of human GABA(A) receptors microtransplanted to Xenopus oocytes. 29 Aug 2009
• A randomized comparative trial of continued zidovudine/lamivudine or replacement with tenofovir disoproxil fumarate/emtricitabine in efavirenz-treated HIV-1-infected individuals. 13 Aug 2009
• The uracil DNA glycosylase UdgB of Mycobacterium smegmatis protects the organism from the mutagenic effects of cytosine and adenine deamination. 12 Aug 2009
• Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB. 9 Aug 2009
• Base pairing configuration and stability of an oligonucleotide duplex containing a 5-chlorouracil-adenine base pair. 9 Aug 2009
• Complete protection from repeated vaginal simian-human immunodeficiency virus exposures in macaques by a topical gel containing tenofovir alone or with emtricitabine. 3 Aug 2009
• Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial. Aug 2009
• Lack of effect of tenofovir disoproxil fumarate on pharmacokinetics of hormonal contraceptives. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Adenine'

Definition: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.

Chemical name: 1H-Purin-6-amine

Registry Number: 73-24-5

Descriptor UI: D000225

Alternative terms: Adenine; Vitamin B 4; 4, Vitamin B; B 4, Vitamin;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; biosynthesis; physiology;

Tree Number: D03.438.759.138;

Technical Notes: /biosyn/physiol permitted