Adenosine Deaminase
Research News and Information

Monday, November 23, 2009

Concomitant activation of P2Y(2) and P2Y(6) receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion.

29 Sep 2009 Extracellular nucleotides regulate a variety of cellular responses involved in inflammation via the activation of P2 receptors. Here, we show that nucleotides regulate TLR2-induced neutrophil migration both in vivo and in vitro. The nucleotide ... Read more...

Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia.

30 Aug 2009 We have previously discovered that the adult Drosophila melanogaster is tolerant to a low O2 environment, withstanding hours of total O2 deprivation without showing any evidence of cell injury. Subsequently, our laboratory embarked on the study of ... Read more...

Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA.

26 Aug 2009 In many cells, mRNAs containing inverted repeats (Alu repeats in humans) in their 3' untranslated regions (3'UTRs) are inefficiently exported to the cytoplasm. Nuclear retention correlates with adenosine-to-inosine editing and is in ... Read more...

Latest indexed articles for 'Adenosine Deaminase'

These are the very latest articles for this heading:

• Concomitant activation of P2Y(2) and P2Y(6) receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion. 29 Sep 2009
• Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia. 30 Aug 2009
• Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA. 26 Aug 2009
• A NEAT way of regulating nuclear export of mRNAs. 26 Aug 2009
• Editing independent effects of ADARs on the miRNA/siRNA pathways. 25 Aug 2009
• Polyethylene glycol-modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency. 6 Aug 2009
• Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy. Aug 2009
• Syzygium cumini inhibits adenosine deaminase activity and reduces glucose levels in hyperglycemic patients. 30 Jul 2009
• Investigation of the patient with pleural effusion. 30 Jul 2009
• Investigation of the patient with pleural effusion. 30 Jul 2009
• RNA editing in human cancer: review. 30 Jul 2009
• Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. 30 Jul 2009
• How I treat ADA deficiency. 26 Jul 2009
• ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency. 22 Jul 2009
• ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication. 13 Jul 2009
• Arabidopsis tRNA adenosine deaminase arginine edits the wobble nucleotide of chloroplast tRNAArg(ACG) and is essential for efficient chloroplast translation. 12 Jul 2009
• Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies. 8 Jul 2009
• British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. 2 Jul 2009
• [New roles of glutamate receptors in glias and gliomas] 29 Jun 2009
• Acute tamoxifen treatment increases nitric oxide level but not total antioxidant capacity and adenosine deaminase activity in the plasma of rabbits. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Adenosine Deaminase'

Definition: An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

Chemical name: Adenosine aminohydrolase

Registry Number: EC 3.5.4.4

Descriptor UI: D000243

Alternative terms: Adenosine Deaminase; Deaminase, Adenosine; Adenosine Aminohydrolase; Aminohydrolase, Adenosine;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.151.486.075;

History Note: 91(75); was see under NUCLEOSIDE DEAMINASES 1975-90

Technical Notes: /defic: consider also SEVERE COMBINED IMMUNODEFICIENCY or SCID