Adenylate Cyclase
Research News and Information

Monday, November 23, 2009

Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning.

28 Sep 2009 Dopamine (DA)-dependent corticostriatal plasticity is thought to underlie incremental procedural learning. A primary effector of striatal DA signaling is cAMP, yet its role in corticostriatal plasticity and striatum-dependent learning remains ... Read more...

Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis.

22 Sep 2009 Dynorphin A (Dyn A) is an endogenous ligand for kappa opioid receptors. To restrict the conformational mobility, we synthesized several cyclic Dyn A-(1-11)NH(2) analogues on solid phase utilizing ring-closing metathesis (RCM) between the side chains ... Read more...

Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner.

17 Sep 2009 We previously demonstrated that prostaglandin EP3 receptor augments EP2-elicited cAMP formation in COS-7 cells in a G(i/o)-insensitive manner. The purpose of our current study was to identify the signaling pathways involved in EP3-induced ... Read more...

Latest indexed articles for 'Adenylate Cyclase'

These are the very latest articles for this heading:

• Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning. 28 Sep 2009
• Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis. 22 Sep 2009
• Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner. 17 Sep 2009
• Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). 11 Sep 2009
• Adenylyl cyclase type 5 protein expression during cardiac development and stress. 2 Sep 2009
• Overexpression of type I adenylyl cyclase in the forebrain impairs spatial memory in aged but not young mice. 31 Aug 2009
• Generation of human PTH1R construct with FLAG epitope located internally: comparison of two-fragment assembly by using PCR overlap extension or ligase. 30 Aug 2009
• Mu opioid receptor from the zebrafish exhibits functional characteristics as those of mammalian mu opioid receptor. 30 Aug 2009
• Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission. 30 Aug 2009
• Hydrostatic pressure-dependent changes in cyclic AMP signaling in optic nerve head astrocytes from Caucasian and African American donors. 18 Aug 2009
• Activation of the epithelial Na+ channel in the collecting duct by vasopressin contributes to water reabsorption. 17 Aug 2009
• Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. 16 Aug 2009
• Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia. 9 Aug 2009
• Nucleotide regulation of soluble guanylate cyclase substrate specificity. 9 Aug 2009
• Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase. Aug 2009
• Possible mechanism of CCL2-induced Akt activation in prostate cancer cells. 30 Jul 2009
• Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase. 30 Jul 2009
• Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor. 30 Jul 2009
• Nitric oxide dilates rat retinal blood vessels by cyclooxygenase-dependent mechanisms. 20 Jul 2009
• Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae. 14 Jul 2009

See a longer list of these articles.

Technical information about 'Adenylate Cyclase'

Definition: An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.

Chemical name: ATP pyrophosphate-lyase (cyclizing)

Registry Number: EC 4.6.1.1

Descriptor UI: D000262

Alternative terms: Adenylate Cyclase; Cyclase, Adenylate; Adenylyl Cyclase; Cyclase, Adenylyl; Adenyl Cyclase; Cyclase, Adenyl;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.520.650.200; D12.644.360.050; D12.776.476.050;

History Note: 98(68)