Adrenergic Agents - Toxicity
Research News and Information

Sunday, November 22, 2009

Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors.

30 Oct 2009 The dopamine D4 receptor (D4R) is predominantly expressed in the prefrontal cortex, a brain area that integrates motor, rewarding, and cognitive information. Because participation of D4Rs in executive learning is largely unknown, we challenged D4R ... Read more...

Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease.

26 Jun 2009 BACKGROUND: New strategies for the treatment of Parkinson's disease (PD) are shifted from dopamine (DA) replacement to regeneration or restoration of the nigro-striatal system. A cell therapy using human retinal pigment epithelial (RPE) cells as ... Read more...

Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease.

23 Jun 2009 The high-fat ketogenic diet (KD) leads to an increase of blood ketone bodies (KB) level and has been used to treat refractory childhood seizures for over 80 years. Recent reports show that KD, KB and their components (d-beta-hydroxybutyrate, ... Read more...

Latest indexed articles for 'Adrenergic Agents - Toxicity'

These are the very latest articles for this heading:

• Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors. 30 Oct 2009
• Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease. 26 Jun 2009
• Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease. 23 Jun 2009
• Effects of dopamine depletion on network entropy in the external globus pallidus. 15 Jun 2009
• Dopamine depletion induces distinct compensatory gene expression changes in DARPP-32 signal transduction cascades of striatonigral and striatopallidal neurons. 25 May 2009
• A role for medial prefrontal dopaminergic innervation in instrumental conditioning. 18 May 2009
• Pigment epithelium derived factor (PEDF) is neuroprotective in two in vitro models of Parkinson's disease. 9 Apr 2009
• Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease. 6 Apr 2009
• Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making. 30 Mar 2009
• Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways. 21 Mar 2009
• Basolateral amygdala D1- and D2-dopaminergic system promotes the formation of long-term potentiation in the dentate gyrus of anesthetized rats. 21 Feb 2009
• Response of neural precursor cells in the brain of Parkinson's disease mouse model after LIF administration. 21 Dec 2008
• Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6-hydroxydopamine-lesioned rats. 29 Nov 2008
• Low frequency stimulation of the pedunculopontine nucleus modulates electrical activity of subthalamic neurons in the rat. 24 Nov 2008
• Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA+parafascicular lesions. 9 Nov 2008
• The neuroprotective effect of dental pulp cells in models of Alzheimer's and Parkinson's disease. 28 Oct 2008
• Preventive effects of genistein on motor dysfunction following 6-hydroxydopamine injection in ovariectomized rats. 17 Oct 2008
• Differential effects of neonatal norepinephrine lesions on immediate early gene expression in developing and adult rat brain. 29 Sep 2008
• Evaluation of behavioural effects of a selective NMDA NR1A/2B receptor antagonist in the unilateral 6-OHDA lesion rat model. 22 Sep 2008
• Involvement of dopamine D2 receptors in the induction of long-term potentiation in the basolateral amygdala-dentate gyrus pathway of anesthetized rats. 21 Sep 2008

See a longer list of these articles.

Technical information about 'Adrenergic Agents'

Definition: Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Registry Number: 0

Descriptor UI: D018663

Alternative terms: Adrenergic Agents; Agents, Adrenergic; Adrenergics; Adrenergic Drugs; Drugs, Adrenergic; Sympathetic Transmitter Releasers; Releasers, Sympathetic Transmitter; Transmitter Releasers, Sympathetic; Adrenergic Release Inhibitors; Inhibitors, Adrenergic Release; Release Inhibitors, Adrenergic; Adrenergic Synthesis Inhibitors; Inhibitors, Adrenergic Synthesis; Synthesis Inhibitors, Adrenergic; Adrenergic Neurohumor Depleters; Depleters, Adrenergic Neurohumor; Neurohumor Depleters, Adrenergic; Adrenergic Neuron Agents; Agents, Adrenergic Neuron; Neuron Agents, Adrenergic; Adrenergic Neuron Drugs; Drugs, Adrenergic Neuron; Neuron Drugs, Adrenergic;

Related Mesh Headings: Sympatholytics; Sympathomimetics;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.625.050; D27.505.696.577.050;

Online Note: use SYMPATHOMIMETICS to search SYMPATHETIC TRANSMITTER RELEASERS 1976-94, ADRENERGIC AGENTS 1977-94 & ADRENOMIMETICS 1975-94; use SYMPATHOLYTICS to search ADRENOLYTICS 1975-94

History Note: 95; was see SYMPATHOMIMETICS 1977-94; ADRENERGIC NEURON AGENTS was heading 1995; ADRENERGIC NEUROHUMOR DEPLETERS, ADRENERGIC RELEASE INHIBITORS, ADRENERGIC SYNTHESIS INHIBITORS, & SYMPATHETIC TRANSMITTER RELEASERS were see ADRENERGIC NEURON AGENTS 1995; SYMPATHETIC TRANSMITTER RELEASERS was see SYMPATHOMIMETICS 1976-94; ADRENOLYTICS was see SYMPATHOLYTICS 1975-94; ADRENOMIMETICS was see SYMPATHOMIMETICS 1975-94

Technical Notes: DF: ADREN AGENTS