Agrin - Biosynthesis
Research News and Information

Sunday, November 22, 2009

Agrin and CD34 immunohistochemistry for the discrimination of benign versus malignant hepatocellular lesions.

30 May 2009 Agrin is a recently identified proteoglycan component of vascular and bile duct basement membranes in the liver. The selective deposition of agrin in hepatocellular carcinoma (HCC) microvessels versus sinusoidal walls prompted us to investigate the ... Read more...

Agrin signalling contributes to cell activation and is overexpressed in T lymphocytes from lupus patients.

29 Nov 2007 It is shown in this study that the heparan sulfate proteoglycan agrin is overexpressed in T cells isolated from patients with the autoimmune disease systemic lupus erythematosus (SLE). Freshly isolated CD4(+) and CD8(+) subpopulations both exhibited ... Read more...

Comparison of the expression of agrin, a basement membrane heparan sulfate proteoglycan, in cholangiocarcinoma and hepatocellular carcinoma.

17 Jul 2007 Heparan sulfate proteoglycans mediate cell adhesion and control the activities of numerous growth and motility factors. They play a critical role in carcinogenesis and tumor progression. Agrin is a large multidomain heparan sulfate proteoglycan ... Read more...

Latest indexed articles for 'Agrin - Biosynthesis'

These are the very latest articles for this heading:

• Agrin and CD34 immunohistochemistry for the discrimination of benign versus malignant hepatocellular lesions. 30 May 2009
• Agrin signalling contributes to cell activation and is overexpressed in T lymphocytes from lupus patients. 29 Nov 2007
• Comparison of the expression of agrin, a basement membrane heparan sulfate proteoglycan, in cholangiocarcinoma and hepatocellular carcinoma. 17 Jul 2007
• Activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mRNA splicing of agrin. 27 Sep 2006
• Induction of glomerular heparanase expression in rats with adriamycin nephropathy is regulated by reactive oxygen species and the renin-angiotensin system. 7 Aug 2006
• Gene profiling and bioinformatic analysis of Schwann cell embryonic development and myelination. 30 Mar 2006
• Angiotensin II type 1-receptor mediated changes in heparan sulfate proteoglycans in human SV40 transformed podocytes. 30 Dec 2003
• Targeting of recombinant agrin to axonal growth cones. 29 Nov 2003
• Agrin in the developing CNS: new roles for a synapse organizer. 29 Sep 2002
• Isoform pattern and AChR aggregation activity of agrin expressed by embryonic chick retinal ganglion neurons. 29 Jun 2002
• Synapse-forming axons and recombinant agrin induce microprocess formation on myotubes. 13 Dec 2001
• Schwann cells express active agrin and enhance aggregation of acetylcholine receptors on muscle fibers. 13 Dec 2001
• Decreased glomerular expression of agrin in diabetic nephropathy and podocytes, cultured in high glucose medium. 30 Dec 2000
• Expression, distribution and ultrastructural localization of the synapse-organizing molecule agrin in the mature avian retina. 29 Nov 1999
• Agrin and the neuromuscular junction. 29 Sep 1998
• Over-expression of acetylcholinesterase stimulates the expression of agrin in NG108-15 cells. 20 May 1998
• Formation of postsynaptic-like membranes during differentiation of embryonic stem cells in vitro. 13 Mar 1998
• Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane. 30 Dec 1997
• Agrin gene expression in mouse somatosensory cortical neurons during development in vivo and in cell culture. 29 Jun 1997
• Induction by agrin of ectopic and functional postsynaptic-like membrane in innervated muscle. 16 Mar 1997

See a longer list of these articles.

Technical information about 'Agrin'

Definition: A protein component of the synaptic basal lamina. It has been shown to induce clustering of acetylcholine receptors on the surface of muscle fibers and other synaptic molecules in both synapse regeneration and development.

Registry Number: 0

Descriptor UI: D018171

Alternative terms: Agrin;

Allowable Qualifiers: supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards;

Tree Number: D12.776.641.050;

Online Note: use AGRIN (NM) to search AGRIN 1988-93

History Note: 94; was AGRIN (NM) 1988-93

Technical Notes: a nerve tissue protein