Agrin - Genetics
Research News and Information

Sunday, November 22, 2009

Identification of an agrin mutation that causes congenital myasthenia and affects synapse function.

21 Jul 2009 We report the case of a congenital myasthenic syndrome due to a mutation in AGRN, the gene encoding agrin, an extracellular matrix molecule released by the nerve and critical for formation of the neuromuscular junction. Gene analysis identified a ... Read more...

Agrin defines polarized distribution of orthogonal arrays of particles in astrocytes.

14 May 2009 Accumulating evidence indicates that agrin, a heparan sulphate proteoglycan of the extracellular matrix, plays a role in the organization and maintenance of the blood-brain barrier. This evidence is based on the differential effects of agrin ... Read more...

Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction.

14 Apr 2009 Drugs that inhibit Na,K-ATPases, such as digoxin and ouabain, alter cardiac myocyte contractility. We recently demonstrated that agrin, a protein first identified at the vertebrate neuromuscular junction, binds to and regulates the activity of ... Read more...

Latest indexed articles for 'Agrin - Genetics'

These are the very latest articles for this heading:

• Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. 21 Jul 2009
• Agrin defines polarized distribution of orthogonal arrays of particles in astrocytes. 14 May 2009
• Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction. 14 Apr 2009
• Agrin pathway is controlled by leukemia inhibitory factor (LIF) in murine implantation. 24 Mar 2009
• Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia. 8 Mar 2009
• Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing. 10 Feb 2009
• Scaffold-forming and Adhesive Contributions of Synthetic Laminin-binding Proteins to Basement Membrane Assembly. 31 Jan 2009
• Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane. 12 Jan 2009
• [Selective deposition of agrin in the microvasculature of hepatocellular carcinoma: aspects in pathogenesis and differential diagnosis] 29 Nov 2008
• Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin. 17 Nov 2008
• LRP4 serves as a coreceptor of agrin. 21 Oct 2008
• Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1. 22 Sep 2008
• O-fucosylation of muscle agrin determines its ability to cluster acetylcholine receptors. 13 Aug 2008
• Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice. 4 Aug 2008
• Dual constraints on synapse formation and regression in schizophrenia: neuregulin, neuroligin, dysbindin, DISC1, MuSK and agrin. 30 Jul 2008
• Agrin expression during synaptogenesis induced by traumatic brain injury. 29 Jun 2008
• Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin. 11 Feb 2008
• Agrin signalling contributes to cell activation and is overexpressed in T lymphocytes from lupus patients. 29 Nov 2007
• Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death. 2 Jul 2007
• Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity. 29 Jun 2007

See a longer list of these articles.

Technical information about 'Agrin'

Definition: A protein component of the synaptic basal lamina. It has been shown to induce clustering of acetylcholine receptors on the surface of muscle fibers and other synaptic molecules in both synapse regeneration and development.

Registry Number: 0

Descriptor UI: D018171

Alternative terms: Agrin;

Allowable Qualifiers: supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards;

Tree Number: D12.776.641.050;

Online Note: use AGRIN (NM) to search AGRIN 1988-93

History Note: 94; was AGRIN (NM) 1988-93

Technical Notes: a nerve tissue protein