Agrin - Immunology
Research News and Information

Sunday, November 22, 2009

[Selective deposition of agrin in the microvasculature of hepatocellular carcinoma: aspects in pathogenesis and differential diagnosis]

29 Nov 2008 Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancers and is the fifth most common malignancy worldwide. HCC typically develops in the cirrhotic liver. Our preliminary results indicated that agrin, a heparan sulfate proteoglycan ... Read more...

Antibody response against the glomerular basement membrane protein agrin in patients with transplant glomerulopathy.

30 Jan 2005 Chronic allograft nephropathy (CAN) of renal allografts is still the most important cause of graft loss. A subset of these patients have transplant glomerulopathy (TGP), characterized by glomerular basement membrane (GBM) duplications, but of ... Read more...

Kissing cousins: immunological and neurological synapses.

29 Jun 2001 Immunological synapse formation is essential for T cell activation. A recent paper in Science reports that immunological and neurological synapses utilize a common molecule, ... Read more...

Latest indexed articles for 'Agrin - Immunology'

These are the very latest articles for this heading:

• [Selective deposition of agrin in the microvasculature of hepatocellular carcinoma: aspects in pathogenesis and differential diagnosis] 29 Nov 2008
• Antibody response against the glomerular basement membrane protein agrin in patients with transplant glomerulopathy. 30 Jan 2005
• Kissing cousins: immunological and neurological synapses. 29 Jun 2001
• Decreased glomerular expression of agrin in diabetic nephropathy and podocytes, cultured in high glucose medium. 30 Dec 2000
• Dystrophin is required for organizing large acetylcholine receptor aggregates. 26 Aug 1999
• Differential expression of agrin in renal basement membranes as revealed by domain-specific antibodies. 8 Jul 1998
• Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane. 30 Dec 1997
• Differential distribution of agrin isoforms in the developing and adult avian retina. 30 Dec 1996
• Agrin is synthesized by retinal cells and colocalizes with gephyrin [corrected] 30 Dec 1995
• Erratic deposition of agrin during the formation of Xenopus neuromuscular junctions in culture. 29 Jun 1995
• Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site. 30 Jan 1995
• Structural domains of agrin required for clustering of nicotinic acetylcholine receptors. 13 Jun 1994

See a longer list of these articles.

Technical information about 'Agrin'

Definition: A protein component of the synaptic basal lamina. It has been shown to induce clustering of acetylcholine receptors on the surface of muscle fibers and other synaptic molecules in both synapse regeneration and development.

Registry Number: 0

Descriptor UI: D018171

Alternative terms: Agrin;

Allowable Qualifiers: supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards;

Tree Number: D12.776.641.050;

Online Note: use AGRIN (NM) to search AGRIN 1988-93

History Note: 94; was AGRIN (NM) 1988-93

Technical Notes: a nerve tissue protein