Agrin - Metabolism
Research News and Information

Saturday, November 21, 2009

Identification of an agrin mutation that causes congenital myasthenia and affects synapse function.

21 Jul 2009 We report the case of a congenital myasthenic syndrome due to a mutation in AGRN, the gene encoding agrin, an extracellular matrix molecule released by the nerve and critical for formation of the neuromuscular junction. Gene analysis identified a ... Read more...

Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis.

15 Jun 2009 In multiple sclerosis (MS), and its animal model experimental autoimmune encephalomyelitis (EAE), dysfunction of the blood-brain barrier (BBB) leads to edema formation within the central nervous system. The molecular mechanisms of edema formation in ... Read more...

Regulation of acetylcholine receptor clustering by ADF/cofilin-directed vesicular trafficking.

29 May 2009 Postsynaptic receptor localization is crucial for synapse development and function, but the underlying cytoskeletal mechanisms remain elusive. Using Xenopus neuromuscular junctions as a model, we found that actin depolymerizing factor (ADF)/cofilin ... Read more...

Latest indexed articles for 'Agrin - Metabolism'

These are the very latest articles for this heading:

• Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. 21 Jul 2009
• Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis. 15 Jun 2009
• Regulation of acetylcholine receptor clustering by ADF/cofilin-directed vesicular trafficking. 29 May 2009
• Agrin defines polarized distribution of orthogonal arrays of particles in astrocytes. 14 May 2009
• The synaptic CT carbohydrate modulates binding and expression of extracellular matrix proteins in skeletal muscle: Partial dependence on utrophin. 10 May 2009
• Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction. 14 Apr 2009
• Aberrant development of neuromuscular junctions in glycosylation-defective Large(myd) mice. 3 Apr 2009
• Agrin, aquaporin-4, and astrocyte polarity as an important feature of the blood-brain barrier. 30 Mar 2009
• Agrin pathway is controlled by leukemia inhibitory factor (LIF) in murine implantation. 24 Mar 2009
• Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage. 18 Mar 2009
• Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia. 8 Mar 2009
• Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing. 10 Feb 2009
• Scaffold-forming and Adhesive Contributions of Synthetic Laminin-binding Proteins to Basement Membrane Assembly. 31 Jan 2009
• Amyloid beta induces cellular relocalization and production of agrin and glypican-1. 5 Jan 2009
• Developmental and pathogenic mechanisms of basement membrane assembly. 30 Dec 2008
• Cell adhesion to agrin presented as a nanopatterned substrate is consistent with an interaction with the extracellular matrix and not transmembrane adhesion molecules. 2 Dec 2008
• A mammalian homolog of Drosophila tumorous imaginal discs, Tid1, mediates agrin signaling at the neuromuscular junction. 24 Nov 2008
• New dogs in the dogma: Lrp4 and Tid1 in neuromuscular synapse formation. 24 Nov 2008
• Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin. 17 Nov 2008
• Caffeine and nicotine decrease acetylcholine receptor clustering in C2C12 myotube culture. 9 Nov 2008

See a longer list of these articles.

Technical information about 'Agrin'

Definition: A protein component of the synaptic basal lamina. It has been shown to induce clustering of acetylcholine receptors on the surface of muscle fibers and other synaptic molecules in both synapse regeneration and development.

Registry Number: 0

Descriptor UI: D018171

Alternative terms: Agrin;

Allowable Qualifiers: supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards;

Tree Number: D12.776.641.050;

Online Note: use AGRIN (NM) to search AGRIN 1988-93

History Note: 94; was AGRIN (NM) 1988-93

Technical Notes: a nerve tissue protein