Agrin - Research News and Information

Wednesday, January 07, 2009

Lrp4 is a receptor for Agrin and forms a complex with MuSK.

7 Oct 2008 Neuromuscular synapse formation requires a complex exchange of signals between motor neurons and skeletal muscle fibers, leading to the accumulation of postsynaptic proteins, including acetylcholine receptors in the muscle membrane and specialized ... Read more...

Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1.

22 Sep 2008 Recent studies suggest that glial cells actively participate in the formation, function, maintenance, and repair of the chemical synapse. However, the molecular mechanisms of glia-synapse interactions are largely unknown. We have shown previously ... Read more...

Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice.

4 Aug 2008 Agrin and its receptor MuSK are required for the formation of the postsynaptic apparatus at the neuromuscular junction (NMJ). In the current model the local deposition of agrin by the nerve and the resulting local activation of MuSK are responsible ... Read more...

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Latest indexed articles for 'Agrin'

These are the very latest articles for this heading:

• Lrp4 is a receptor for Agrin and forms a complex with MuSK. 7 Oct 2008
• Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1. 22 Sep 2008
• Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice. 4 Aug 2008
• Neural agrin increases postsynaptic ACh receptor packing by elevating rapsyn protein at the mouse neuromuscular synapse. 30 Jul 2008
• Dual constraints on synapse formation and regression in schizophrenia: neuregulin, neuroligin, dysbindin, DISC1, MuSK and agrin. 30 Jul 2008
• Nicotine-induced phosphorylation of phosphorylated cyclic AMP response element-binding protein (pCREB) in hippocampal neurons is potentiated by agrin. 10 Jul 2008
• Agrin expression during synaptogenesis induced by traumatic brain injury. 29 Jun 2008
• [Basic and clinical importance of nicotinic acetylcholine receptors] 29 Jun 2008
• Revisiting the glomerular charge barrier in the molecular era. 29 Jun 2008
• Retina development in zebrafish requires the heparan sulfate proteoglycan agrin. 30 May 2008
• Localized acetylcholine receptor clustering dynamics in response to microfluidic focal stimulation with agrin. 21 May 2008
• The role of nerve- versus muscle-derived factors in mammalian neuromuscular junction formation. 24 Mar 2008
• Heparan sulfate proteoglycans in the basement membranes of the human placenta and decidua. 2 Mar 2008
• Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin. 11 Feb 2008
• alpha-Dystrobrevin isoforms differ in their colocalization with and stabilization of agrin-induced acetylcholine receptor clusters. 8 Feb 2008
• Neurotrypsin cleaves agrin locally at the synapse. 27 Jan 2008
• The zebrafish ennui behavioral mutation disrupts acetylcholine receptor localization and motor axon stability. 30 Dec 2007
• MuSK controls where motor axons grow and form synapses. 14 Dec 2007
• Agrin and neuregulin, expanding roles and implications for therapeutics. 2 Dec 2007
• Agrin signalling contributes to cell activation and is overexpressed in T lymphocytes from lupus patients. 29 Nov 2007

See a longer list of these articles.

Technical information about 'Agrin'

Definition: A protein component of the synaptic basal lamina. It has been shown to induce clustering of acetylcholine receptors on the surface of muscle fibers and other synaptic molecules in both synapse regeneration and development.

Registry Number: 0

Descriptor UI: D018171

Alternative terms: Agrin;

Allowable Qualifiers: supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards;

Tree Number: D12.776.641.050;

Online Note: use AGRIN (NM) to search AGRIN 1988-93

History Note: 94; was AGRIN (NM) 1988-93

Technical Notes: a nerve tissue protein