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Agrin - Research News and Information

Wednesday, January 07, 2009

Definition of 'Agrin'

A protein component of the synaptic basal lamina. It has been shown to induce clustering of acetylcholine receptors on the surface of muscle fibers and other synaptic molecules in both synapse regeneration and development.

Common names: Agrin

More technical Information...

Lrp4 is a receptor for Agrin and forms a complex with MuSK.

7 Oct 2008 Neuromuscular synapse formation requires a complex exchange of signals between motor neurons and skeletal muscle fibers, leading to the accumulation of postsynaptic proteins, including acetylcholine receptors in the muscle membrane and specialized ... Read more...


Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1.

22 Sep 2008 Recent studies suggest that glial cells actively participate in the formation, function, maintenance, and repair of the chemical synapse. However, the molecular mechanisms of glia-synapse interactions are largely unknown. We have shown previously ... Read more...


Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice.

4 Aug 2008 Agrin and its receptor MuSK are required for the formation of the postsynaptic apparatus at the neuromuscular junction (NMJ). In the current model the local deposition of agrin by the nerve and the resulting local activation of MuSK are responsible ... Read more...

 

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Technical information about 'Agrin'

Definition: A protein component of the synaptic basal lamina. It has been shown to induce clustering of acetylcholine receptors on the surface of muscle fibers and other synaptic molecules in both synapse regeneration and development.

Registry Number: 0

Descriptor UI: D018171

Alternative terms: Agrin;

Allowable Qualifiers: supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards;

Tree Number: D12.776.641.050;

Online Note: use AGRIN (NM) to search AGRIN 1988-93

History Note: 94; was AGRIN (NM) 1988-93

Technical Notes: a nerve tissue protein

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