Aldehyde Dehydrogenase - Deficiency
Research News and Information

Saturday, November 21, 2009

Pyridoxine-dependent epilepsy: normal outcome in a patient with late diagnosis after prolonged status epilepticus causing cortical blindness.

15 Mar 2009 We report on a male proband with pyridoxine-dependent epilepsy (PDE) and neonatal seizure onset. At the age of 31 months, a prolonged status epilepticus led to severe neurological regression with cortical blindness, loss of speech and muscular ... Read more...

Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction.

30 Jun 2008 AIMS: Imbalance between pro- and antioxidant species (e.g. during aging) plays a crucial role for vascular function and is associated with oxidative gene regulation and modification. Vascular aging is associated with progressive deterioration of ... Read more...

Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity.

9 Jun 2008 Oxidative stress may underlie age-dependent memory loss and cognitive decline. Toxic aldehydes, including 4-hydroxy-2-nonenal (HNE), an end product of lipid peroxides, are known to accumulate in the brain in neurodegenerative disease. We have ... Read more...

Latest indexed articles for 'Aldehyde Dehydrogenase - Deficiency'

These are the very latest articles for this heading:

• The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. 22 Mar 2009
• Pyridoxine-dependent epilepsy: normal outcome in a patient with late diagnosis after prolonged status epilepticus causing cortical blindness. 15 Mar 2009
• Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction. 30 Jun 2008
• Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. 9 Jun 2008
• Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to acetaldehyde. 30 Jan 2008
• ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties. 24 Dec 2007
• Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts. 3 Dec 2007
• Single-dose ethanol administration downregulates expression of cytochrome p450 2E1 mRNA in aldehyde dehydrogenase 2 knockout mice. 3 Nov 2007
• Ethanol-induced oxidative DNA damage and CYP2E1 expression in liver tissue of Aldh2 knockout mice. 30 Aug 2007
• Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice. 11 Jun 2007
• Alpha-aminoadipic semialdehyde is the biomarker for pyridoxine dependent epilepsy caused by alpha-aminoadipic semialdehyde dehydrogenase deficiency. 6 Jun 2007
• Carcinogenicity of alcoholic beverages. 30 Mar 2007
• Pyridoxal phosphate dependency, a newly recognized treatable catastrophic epileptic encephalopathy. 30 Jan 2007
• Lack of aldehyde dehydrogenase ameliorates oxidative stress induced by single-dose ethanol administration in mouse liver. 30 Jan 2007
• Mendelian randomization: a novel test of the gateway hypothesis and models of gene-environment interplay. 30 Dec 2006
• Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice. 30 Dec 2006
• [Alcohol consumption and cancer of gastrointestinal tract in the Japanese: an epidemiological review] 29 Nov 2006
• Proton magnetic resonance spectroscopy findings and clinical effects of montelukast sodium in a case with Sjögren-Larsson syndrome. 29 Nov 2006
• Increased DNA damage in ALDH2-deficient alcoholics. 29 Sep 2006
• Drug eruptions to contrast media in Japan. 29 Apr 2006

See a longer list of these articles.

Technical information about 'Aldehyde Dehydrogenase'

Definition: An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.

Chemical name: Aldehyde:NAD+ oxidoreductase

Registry Number: EC 1.2.1.3

Descriptor UI: D000444

Alternative terms: Aldehyde Dehydrogenase; Dehydrogenase, Aldehyde; D-Glucuronolactone Dehydrogenase; D Glucuronolactone Dehydrogenase; Dehydrogenase, D-Glucuronolactone; Aldehyde Dehydrogenase (NAD(+)); Aldehyde-NAD Oxidoreductase; Aldehyde NAD Oxidoreductase; Aldehyde Dehydrogenase E2; Aldehyde Dehydrogenase E1;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.682.657.163.249;

History Note: 85