Aldehyde Dehydrogenase - Genetics
Research News and Information

Monday, November 23, 2009

ALDH2, ADH1B and alcohol expectancies: integrating genetic and learning perspectives.

30 Aug 2009 The present study evaluated associations of ALDH2 and ADH1B genotypes with alcohol expectancies and drinking behavior in a sample of Asian American young adults. In addition to assessing global alcohol expectancies, the authors developed a measure ... Read more...

Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.

30 Aug 2009 Genetic variants in alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) genes modulate acetaldehyde removal upon alcohol ingestion. Although these genetic vulnerabilities have been linked to higher esophageal squamous cell ... Read more...

Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice.

19 Aug 2009 Oxidative stress is one of the major causes of age-dependent memory loss and cognitive decline. Cytotoxic aldehydes are derived from lipid peroxides and their accumulation may be responsible for age-dependent neurodegeneration, including Alzheimer's ... Read more...

Latest indexed articles for 'Aldehyde Dehydrogenase - Genetics'

These are the very latest articles for this heading:

• ALDH2, ADH1B and alcohol expectancies: integrating genetic and learning perspectives. 30 Aug 2009
• Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis. 30 Aug 2009
• Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice. 19 Aug 2009
• Interaction of the effects of alcohol drinking and polymorphisms in alcohol-metabolizing enzymes on the risk of female breast cancer in Japan. 6 Aug 2009
• Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: implications for retinoid balance in gonad development. 30 Jul 2009
• Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. 30 Jul 2009
• Salivary aldehyde dehydrogenase: activity towards aromatic aldehydes and comparison with recombinant ALDH3A1. 30 Jun 2009
• Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4. 29 Jun 2009
• Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model. 19 Jun 2009
• Role of the general base Glu-268 in nitroglycerin bioactivation and superoxide formation by aldehyde dehydrogenase-2. 6 Jun 2009
• Vitamins, not surgery: spinal fluid testing in hemispheric epilepsy. 30 May 2009
• Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes. 27 May 2009
• Polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 and esophageal cancer risk in Southeast Chinese males. 19 May 2009
• Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer. 16 May 2009
• Subcortical oligodendrocyte- and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder. 15 May 2009
• Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant. 29 Apr 2009
• Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsy. 29 Apr 2009
• Effect of process parameters on 3-hydroxypropionic acid production from glycerol using a recombinant Escherichia coli. 6 Apr 2009
• Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups. 30 Mar 2009
• Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Aldehyde Dehydrogenase'

Definition: An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.

Chemical name: Aldehyde:NAD+ oxidoreductase

Registry Number: EC 1.2.1.3

Descriptor UI: D000444

Alternative terms: Aldehyde Dehydrogenase; Dehydrogenase, Aldehyde; D-Glucuronolactone Dehydrogenase; D Glucuronolactone Dehydrogenase; Dehydrogenase, D-Glucuronolactone; Aldehyde Dehydrogenase (NAD(+)); Aldehyde-NAD Oxidoreductase; Aldehyde NAD Oxidoreductase; Aldehyde Dehydrogenase E2; Aldehyde Dehydrogenase E1;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.682.657.163.249;

History Note: 85