Allopurinol - Research News and Information

Wednesday, January 07, 2009

Mitochondrial ischemia-reperfusion injury of the transplanted rat heart: improved protection by preservation versus cardioplegic solutions.

29 Sep 2008 Cold ischemia time and preservation of organs are limited by I/R injury leading to primary nonfunction of the graft. In a rat heart transplant model, we compared cardioplegic St Thomas (ST) to histidine-tryptophan-ketoglutarate (HTK) and University ... Read more...

Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptor.

29 Sep 2008 It is widely recognized that L-NAME exposed rats develop myocardial fibrosis and hypertrophy. The aim of this study was to evaluate the contribution of xanthine oxidase (XO) to these phenomena using allopurinol, isolated or associated with ... Read more...

Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase.

23 Sep 2008 Reduction of nitrite (NO(2)(-)) provides a major source of nitric oxide (NO) in the circulation, especially in hypoxemic conditions. Our previous studies suggest that xanthine oxidoreductase (XOR) is an important nitrite reductase in the heart and ... Read more...

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Latest indexed articles for 'Allopurinol'

These are the very latest articles for this heading:

• Mitochondrial ischemia-reperfusion injury of the transplanted rat heart: improved protection by preservation versus cardioplegic solutions. 29 Sep 2008
• Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptor. 29 Sep 2008
• Allopurinol hypersensitivity and DRESS syndrome. 29 Sep 2008
• Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase. 23 Sep 2008
• Calcium-supplemented University of Wisconsin solution in long-term myocardial preservation. 30 Aug 2008
• Meta-analysis: allopurinol in the prevention of postendoscopic retrograde cholangiopancreatography pancreatitis. 30 Aug 2008
• Thiopurine hepatotoxicity in inflammatory bowel disease: the role for adding allopurinol. 30 Aug 2008
• Extranodal gammadelta-T-cell lymphoma in a dog with leishmaniasis. 30 Aug 2008
• [Measures against hyperuricemia] 30 Aug 2008
• The minimal flush volume for washout of preservation fluid in liver transplantation. 30 Aug 2008
• Hypoxia and reoxygenation of the lung tissues induced mRNA expressions of superoxide dismutase and catalase and interventions from different antioxidants. 30 Aug 2008
• Plasma superoxide radical in jaundiced patients and role of xanthine oxidase. 30 Aug 2008
• [Observation on therapeutic effect of electroacupuncture combined with local blocking therapy on acute gouty arthritis] 30 Aug 2008
• Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. 25 Aug 2008
• Allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis. 30 Jul 2008
• A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania. 30 Jul 2008
• Prevention of acute kidney injury. 30 Jul 2008
• Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution in intestinal and multivisceral transplantation. 25 Jul 2008
• Improvement of canine islet yield by donor pancreas infusion with a p38MAPK inhibitor. 25 Jul 2008
• A comparison of reactive oxygen species metabolism in the rat aorta and vena cava: focus on xanthine oxidase. 23 Jul 2008

See a longer list of these articles.

Technical information about 'Allopurinol'

Definition: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.

Chemical name: 4H-Pyrazolo(3,4-d)pyrimidin-4-one, 1,5-dihydro-

Registry Number: 315-30-0

Descriptor UI: D000493

Alternative terms: Allopurinol; Zyloprim; Wellcome Brand of Allopurinol; Allopurinol Wellcome Brand; Zyloric; Glaxo Wellcome Brand of Allopurinol; Allopurin; Bicther Brand of Allopurinol; Allopurinol Bicther Brand; Allorin; Douglas Brand of Allopurinol; Allopurinol Douglas Brand; Allpargin; Merz Brand of Allopurinol; Allopurinol Merz Brand; Allural; Pan Quimica; Quimica, Pan; Apulonga; Dorsch Brand of Allopurinol; Allopurinol Dorsch Brand; Apurin; Multipharma Brand of Allopurinol; Allopurinol Multipharma Brand; Atisuril; Byk Gulden Brand of Allopurinol; Bleminol; gepepharm Brand of Allopurinol; Allopurinol gepepharm Brand; Caplenal; Rhône-Poulenc Rorer Brand of Allopurinol; Rhône Poulenc Rorer Brand of Allopurinol; APS Brand of Allopurinol; Allopurinol APS Brand; Capurate; Fawns & McAllan Brand of Allopurinol; Cellidrin; Hennig Brand of Allopurinol; Allopurinol Hennig Brand; Embarin; Suspendol; Merckle Brand of Allopurinol; Allopurinol Merckle Brand; Foligan; Henning Berlin Brand of Allopurinol; Hamarin; Nicholas Brand of Allopurinol; Allopurinol Nicholas Brand; Jenapurinol; Jenapharm Brand of Allopurinol; Allopurinol Jenapharm Brand; Lopurin; Boots Brand of Allopurinol; Allopurinol Boots Brand; Lysuron; Boehringer Mannheim Brand of Allopurinol; Milurit; Milurite; Thiemann Brand of Allopurinol; Allopurinol Thiemann Brand; Novopurol; Novopharm Brand of Allopurinol; Allopurinol Novopharm Brand; Progout; Protea Brand of Allopurinol; Allopurinol Protea Brand; Alphapharm Brand of Allopurinol; Allopurinol Alphapharm Brand; Pureduct; Rosen Brand of Allopurinol; Allopurinol Rosen Brand; Purinol; Pinewood Brand of Allopurinol; Allopurinol Pinewood Brand; Horner Brand of Allopurinol; Allopurinol Horner Brand; Remid; TAD Brand of Allopurinol; Allopurinol TAD Brand; Rimapurinol; Rima Brand of Allopurinol; Allopurinol Rima Brand; Roucol; Rougier Brand of Allopurinol; Allopurinol Rougier Brand; Tipuric; Clonmel Brand of Allopurinol; Allopurinol Clonmel Brand; Uribenz; R.A.N. Brand of Allopurinol; Allopurinol R.A.N. Brand; Uridocid; Reig Jofre Brand of Allopurinol; Uripurinol; Azupharma Brand of Allopurinol; Allopurinol Azupharma Brand; Urosin; Roche Brand of Allopurinol; Allopurinol Roche Brand; Urtias; BASF Brand of Allopurinol; Allopurinol BASF Brand; Xanthomax; Ashbourne Brand of Allopurinol; Allopurinol Ashbourne Brand; Xanturic; Pharmafarm Brand of Allopurinol; Allopurinol Pharmafarm Brand; Zygout; Amrad Brand of Allopurinol; Allopurinol Amrad Brand; Allohexal; Hexal Brand of Allopurinol; Allopurinol Hexal Brand; Allohexan; Alloprin; ICN Brand of Allopurinol; Allopurinol ICN Brand;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Enzyme Inhibitors; Gout Suppressants; Free Radical Scavengers; Antimetabolites;

Tree Number: D03.438.759.160;

History Note: 68(67)