Allosteric Regulation - Research News and Information

Wednesday, January 07, 2009

Surface sites for engineering allosteric control in proteins.

15 Oct 2008 Statistical analyses of protein families reveal networks of coevolving amino acids that functionally link distantly positioned functional surfaces. Such linkages suggest a concept for engineering allosteric control into proteins: The intramolecular ... Read more...

Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain.

8 Oct 2008 Vibrio cholerae RTX (repeats in toxin) is an actin-disrupting toxin that is autoprocessed by an internal cysteine protease domain (CPD). The RTX CPD is efficiently activated by the eukaryote-specific small molecule inositol hexakisphosphate ... Read more...

Variations in clique and community patterns in protein structures during allosteric communication: investigation of dynamically equilibrated structures of methionyl tRNA synthetase complexes.

7 Oct 2008 The allosteric concept has played a key role in understanding the biological functions of proteins. The rigidity or plasticity and the conformational population are the two important ideas invoked in explaining the allosteric effect. Although ... Read more...

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Latest indexed articles for 'Allosteric Regulation'

These are the very latest articles for this heading:

• Surface sites for engineering allosteric control in proteins. 15 Oct 2008
• Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. 8 Oct 2008
• Variations in clique and community patterns in protein structures during allosteric communication: investigation of dynamically equilibrated structures of methionyl tRNA synthetase complexes. 7 Oct 2008
• Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. 29 Sep 2008
• Mapping a molecular link between allosteric inhibition and activation of the glycine receptor. 19 Sep 2008
• Inversion of allosteric effect of arginine on N-acetylglutamate synthase, a molecular marker for evolution of tetrapods. 16 Sep 2008
• Time evolution of the quaternary structure of Escherichia coli aspartate transcarbamoylase upon reaction with the natural substrates and a slow, tight-binding inhibitor. 14 Sep 2008
• Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. 10 Sep 2008
• Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center. 9 Sep 2008
• 2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists. 3 Sep 2008
• Stress, health and ageing: a focus on postmenopausal women. 30 Aug 2008
• Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor. 24 Aug 2008
• Sulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline state. 21 Aug 2008
• Structural analysis of the human Rad51 protein-DNA complex filament by tryptophan fluorescence scanning analysis: transmission of allosteric effects between ATP binding and DNA binding. 20 Aug 2008
• Crystallographic structure of phosphofructokinase-2 from Escherichia coli in complex with two ATP molecules. Implications for substrate inhibition. 20 Aug 2008
• Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator. 18 Aug 2008
• Interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor. 13 Aug 2008
• Dynamical characterization of the heme NO oxygen binding (HNOX) domain. Insight into soluble guanylate cyclase allosteric transition. 13 Aug 2008
• Antiretroviral therapy-induced functional modification of IgG4 and IgM responses in HIV-1-infected individuals screened by an allosteric biosensor. 13 Aug 2008
• The structure of SgrAI bound to DNA; recognition of an 8 base pair target. 11 Aug 2008

See a longer list of these articles.

Technical information about 'Allosteric Regulation'

Definition: The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.

Descriptor UI: D000494

Alternative terms: Allosteric Regulation; Regulation, Allosteric; Allosteric Regulations; Regulations, Allosteric;

Related Mesh Headings: Allosteric Site;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.087.040; G02.149.115.040;

History Note: 78(71); was see under BIOCHEMISTRY 1975-77

Technical Notes: almost never IM; DF: ALLOSTERIC REG