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Allosteric Regulation - Research News and Information

Wednesday, January 07, 2009

Definition of 'Allosteric Regulation'

The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.

Common names: Allosteric Regulation; Regulation, Allosteric; Allosteric Regulations; Regulations, Allosteric

More technical Information...

Surface sites for engineering allosteric control in proteins.

15 Oct 2008 Statistical analyses of protein families reveal networks of coevolving amino acids that functionally link distantly positioned functional surfaces. Such linkages suggest a concept for engineering allosteric control into proteins: The intramolecular ... Read more...


Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain.

8 Oct 2008 Vibrio cholerae RTX (repeats in toxin) is an actin-disrupting toxin that is autoprocessed by an internal cysteine protease domain (CPD). The RTX CPD is efficiently activated by the eukaryote-specific small molecule inositol hexakisphosphate ... Read more...


Variations in clique and community patterns in protein structures during allosteric communication: investigation of dynamically equilibrated structures of methionyl tRNA synthetase complexes.

7 Oct 2008 The allosteric concept has played a key role in understanding the biological functions of proteins. The rigidity or plasticity and the conformational population are the two important ideas invoked in explaining the allosteric effect. Although ... Read more...

 

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Technical information about 'Allosteric Regulation'

Definition: The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.

Descriptor UI: D000494

Alternative terms: Allosteric Regulation; Regulation, Allosteric; Allosteric Regulations; Regulations, Allosteric;

Related Mesh Headings: Allosteric Site;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.087.040; G02.149.115.040;

History Note: 78(71); was see under BIOCHEMISTRY 1975-77

Technical Notes: almost never IM; DF: ALLOSTERIC REG

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