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Allosteric Regulation
Research News and Information
Definition of 'Allosteric Regulation'The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES. Common names: Allosteric Regulation; Regulation, Allosteric; Allosteric Regulations; Regulations, Allosteric |
Sunday, November 22, 2009
21 Oct 2009 
On average, each human gene has approximately four SNPs (single nucleotide polymorphisms) in the coding region, half of which are nsSNPs (non-synonymous SNPs) or missense SNPs. Current attention is focused on those that are known to perturb function ... Read more...
Synergistic regulation and ligand-induced conformational changes of tryptophan synthase.
18 Oct 2009 Conformational changes of enzyme complexes are often related to regulating and creating an optimal environment for efficient chemistry. We investigated the synergistic regulation of the tryptophan synthase (TRPS) complex, studied for decades as a ... Read more...
Characterization of the CHK1 allosteric inhibitor binding site.
18 Oct 2009 Checkpoint kinase 1 (CHK1) is a key element in the DNA damage response pathway and plays a crucial role in the S-G(2)-phase checkpoint. Inhibiting CHK1 is a therapeutic strategy involving abrogation of the G2/M mitotic checkpoint defense of tumor ... Read more...
Latest indexed articles for 'Allosteric Regulation'
These are the very latest articles for this heading:
- How do transcription factors select specific binding sites in the genome?
30 Oct 2009 - A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity. 21 Oct 2009
- Synergistic regulation and ligand-induced conformational changes of tryptophan synthase. 18 Oct 2009
- Characterization of the CHK1 allosteric inhibitor binding site. 18 Oct 2009
- Allosteric functional switch of neurokinin A-mediated signaling at the neurokinin NK2 receptor: structural exploration. 6 Oct 2009
- Structural insights into mechanisms of the small RNA methyltransferase HEN1. 6 Oct 2009
- Cooperative binding of two acetylation marks on a histone tail by a single bromodomain. 29 Sep 2009
- Role of the polycomb protein EED in the propagation of repressive histone marks. 18 Sep 2009
- Probing the allosteric modulator binding site of GluR2 with thiazide derivatives. 13 Sep 2009
- Cyclic-di-GMP-binding CRP-like protein: a spectacular new role for a veteran signal transduction actor. 9 Sep 2009
- An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases. 9 Sep 2009
- The alternating power stroke of a 6-cylinder AAA protease chaperone engine. 9 Sep 2009
- Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets. 31 Aug 2009
- '7TM receptor allostery: putting numbers to shapeshifting proteins. 31 Aug 2009
- Identification of domains involved in the allosteric regulation of cytosolic Arabidopsis thaliana NADP-malic enzymes. 31 Aug 2009
- Complexes of HIV-1 integrase with HAT proteins: multiscale models, dynamics, and hypotheses on allosteric sites of inhibition. 30 Aug 2009
- Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia. 30 Aug 2009
- Analysis of insulin allostery in solution and solid state with FTIR. 30 Aug 2009
- Mutagenesis studies toward understanding allostery in thrombin. 30 Aug 2009
- Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. 28 Aug 2009
See a longer list of these articles.
Technical information about 'Allosteric Regulation'
Definition: The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.
Descriptor UI: D000494
Alternative terms: Allosteric Regulation; Regulation, Allosteric; Allosteric Regulations; Regulations, Allosteric;
Related Mesh Headings: Allosteric Site;
Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;
Tree Number: G02.111.087.040; G02.149.115.040;
History Note: 78(71); was see under BIOCHEMISTRY 1975-77
Technical Notes: almost never IM; DF: ALLOSTERIC REG