alpha 1-Antitrypsin - Immunology
Research News and Information

Friday, March 19, 2010

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.

30 Jul 2009 The mechanisms of tolerance in the liver that limit susceptibility to food allergy and that mediate the acceptance of liver transplants, even with a complete major histocompatibility complex (MHC) mismatch, remain poorly defined. Here we report that ... Read more...

Proximity ligation measurement of the complex between prostate specific antigen and alpha1-protease inhibitor.

28 Jul 2009 BACKGROUND: Prostate specific antigen (PSA)-alpha1-protease inhibitor complex (PSA-API) is a minor form of PSA in serum. It may be useful for prostate cancer (PCa) diagnosis, but its specific detection is hampered by nonspecific background. To avoid ... Read more...

Hepatoid carcinoma of the skin: spontaneous rat skin hepatoid carcinoma with eosinophilic globules and crystals immunoreactive to alpha-1-antitrypsin.

16 Jun 2009 We present a case of hepatoid carcinoma of the abdominal skin in a male Wistar rat. Histopathologically, this carcinoma resembled human hepatocellular carcinoma with respect to trabecular-sinusoidal structures. Carcinoma tissues contain numerous ... Read more...

Latest indexed articles for 'alpha 1-Antitrypsin - Immunology'

These are the very latest articles for this heading:

• Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver. 30 Jul 2009
• Proximity ligation measurement of the complex between prostate specific antigen and alpha1-protease inhibitor. 28 Jul 2009
• Hepatoid carcinoma of the skin: spontaneous rat skin hepatoid carcinoma with eosinophilic globules and crystals immunoreactive to alpha-1-antitrypsin. 16 Jun 2009
• The use of two-dimension electrophoresis to identify serum biomarkers from patients with dengue haemorrhagic fever. 6 Feb 2009
• Enhancement of ovalbumin-induced pulmonary eosinophilia by intranasal administration of alpha1-proteinase inhibitor type 2 antisense oligonucleotides. 23 Dec 2008
• Multifunctional protein microarrays for cultivation of cells and immunodetection of secreted cellular products. 20 Jul 2008
• Apparently nonspecific enzyme elevations after portal vein delivery of recombinant adeno-associated virus serotype 2 vector in hepatitis C virus-infected chimpanzees. 29 Jun 2008
• Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin. 12 Jan 2008
• Immunomodulation by alpha(1)-proteinase inhibitor: lack of chemotactic effects of recombinant human alpha(1)-proteinase inhibitor from yeast on human peripheral blood granulocytes. Dec 2007
• Antigen-specific tolerance of human alpha1-antitrypsin induced by helper-dependent adenovirus. 29 Nov 2007
• Detection of an isoform of alpha(1)-antitrypsin in serum samples from foals with gastric ulcers. 6 Sep 2007
• Isolation and characterization of alpha1-proteinase inhibitor from common carp (Cyprinus carpio) seminal plasma. 17 Jun 2007
• Discovery of VIRIP--a natural HIV entry inhibitor. 30 Mar 2007
• Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector. 30 May 2006
• The use of rabbit polyclonal antibodies to assess neoantigenicity following viral reduction of an alpha-1-proteinase inhibitor preparation. Feb 2006
• Analysis of epitopes on the unrelated proteins thyrotropin receptor and alpha 1-antitrypsin which are recognized by A10 monoclonal antibody. 29 Nov 2005
• Identification of immunodominant autoantigens in rat autoimmune orchitis. 29 Sep 2005
• Saving islets from allograft rejection. 27 Aug 2005
• Enhancing rAAV vector expression in the lung. 29 Jun 2005
• Antibody response to aerosolized transgenic human alpha1-antitrypsin. 10 May 2005

See a longer list of these articles.

Technical information about 'alpha 1-Antitrypsin'

Definition: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES. Commonly referred to as alpha 1-proteinase inhibitor (A1PI), it exists in over 30 different biochemical variant forms known collectively as the Pi (protease inhibitor) system. Hereditary A1PI deficiency is associated with PULMONARY EMPHYSEMA.

Registry Number: 0

Descriptor UI: D000515

Alternative terms: alpha 1-Antitrypsin; alpha 1 Antitrypsin; alpha 1-Proteinase Inhibitor; Inhibitor, alpha 1-Proteinase; alpha 1 Proteinase Inhibitor; Trypsin Inhibitor, alpha 1-Antitrypsin; Trypsin Inhibitor, alpha 1 Antitrypsin; alpha 1-Antiproteinase; 1-Antiproteinase, alpha; alpha 1 Antiproteinase; A1PI; alpha 1 Antiprotease; Antiprotease, alpha 1; alpha 1-Protease Inhibitor; Inhibitor, alpha 1-Protease; alpha 1 Protease Inhibitor; Zemaira; Prolastin; alpha 1-Proteinase Inhibitor F; alpha 1 Proteinase Inhibitor F; alpha 1-Proteinase Inhibitor S; alpha 1 Proteinase Inhibitor S;

Related Mesh Headings: alpha 1-Antitrypsin Deficiency;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Pharmacological Action: Serine Proteinase Inhibitors; Trypsin Inhibitors;

Tree Number: D12.644.822.374; D12.776.124.050.070; D12.776.124.790.106.085; D12.776.377.715.085.085; D12.776.645.374; D12.776.872.035;

History Note: 74