alpha 1-Antitrypsin Deficiency - Therapy
Research News and Information

Sunday, November 22, 2009

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy.

10 Aug 2009 Alpha-1 antitrypsin (AAT) deficiency is well-suited as a target for human gene transfer. We performed a phase 1, open-label, dose-escalation clinical trial of a recombinant adeno-associated virus (rAAV) vector expressing normal (M) AAT packaged into ... Read more...

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies.

12 May 2009 alpha1-Antitrypsin is the prototypical member of the serine proteinase inhibitor or serpin superfamily of proteins. The family includes alpha1-antichymotrypsin, C1 inhibitor, antithrombin and neuroserpin, which are all linked by a common molecular ... Read more...

Lung volume reduction surgery for patients with alpha-1 antitrypsin deficiency emphysema.

29 Apr 2009 Currently, A1AD is recognized in approximately 2% of patients who have emphysema, although this may be an underestimation of the prevalence of this disease. Given the relatively young age at which patients who have A1AD present with emphysema, ... Read more...

Latest indexed articles for 'alpha 1-Antitrypsin Deficiency - Therapy'

These are the very latest articles for this heading:

• Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. 10 Aug 2009
• Clinical practice. Alpha1-antitrypsin deficiency. 23 Jun 2009
• [Alpha-1-antitrypsin deficiency: diagnosis and therapy of the lung disease] 8 Jun 2009
• Your racing horses will help you to quit: a lesson for COPD and alpha1-antitrypsin deficiency research. 30 May 2009
• alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies. 12 May 2009
• Lung volume reduction surgery for patients with alpha-1 antitrypsin deficiency emphysema. 29 Apr 2009
• Inherited metabolic disease of the liver. 29 Apr 2009
• Myths and misconceptions about {alpha}1-antitrypsin deficiency. 21 Mar 2009
• Effects of a disease management program in individuals with alpha-1 antitrypsin deficiency. 30 Jan 2009
• Rate of progression of lung function impairment in alpha1-antitrypsin deficiency. 20 Jan 2009
• Are your COPD patients benefiting from best practices? 30 Jul 2008
• [Alpha-1 antitrypsin deficiency: diagnosis and treatment] 29 Jun 2008
• Inherited metabolic disease of the liver. 29 Apr 2008
• Alpha-1 antitrypsin deficiency: from Italy to the world. 29 Nov 2007
• Pulmonary delivery of nucleic acids. 30 Oct 2007
• AANA journal course. Update for nurse anesthetists--part 4--life in the balance: the role of serpins in disease genesis and prevention. 29 Sep 2007
• Progress and prospects: gene therapy clinical trials (part 1). 29 Sep 2007
• The promise of gene therapy for the treatment of alpha-1 antitrypsin deficiency. 30 Aug 2007
• Alpha1-antitrypsin deficiency in childhood. 30 Jul 2007
• Alpha-1-antitrypsin deficiency: current concepts. 10 Jun 2007

See a longer list of these articles.

Technical information about 'alpha 1-Antitrypsin Deficiency'

Definition: Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN, leading primarily to degradation of elastin of the alveolar walls, as well as other structural proteins of a variety of tissues. (From Scriver, Beaudet, Sly, & Valle, The Metabolic and Molecular Bases of Inherited Disease, 7th ed, p4125)

Descriptor UI: D019896

Alternative terms: alpha 1-Antitrypsin Deficiency; Deficiencies, alpha 1-Antitrypsin; Deficiency, alpha 1-Antitrypsin; alpha 1 Antitrypsin Deficiency; alpha 1-Antitrypsin Deficiencies;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C17.300.050;

History Note: 98

Technical Notes: Pi or PiZZ goes here + PHENOTYPE; DF: ALPHA 1 ANTITRYPSIN DEFIC