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alpha 1-Antitrypsin Deficiency
Research News and Information
Definition of 'alpha 1-Antitrypsin Deficiency'Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN, leading primarily to degradation of elastin of the alveolar walls, as well as other structural proteins of a variety of tissues. (From Scriver, Beaudet, Sly, & Valle, The Metabolic and Molecular Bases of Inherited Disease, 7th ed, p4125) Common names: alpha 1-Antitrypsin Deficiency; Deficiencies, alpha 1-Antitrypsin; Deficiency, alpha 1-Antitrypsin; alpha 1 Antitrypsin Deficiency; alpha 1-Antitrypsin Deficiencies |
Monday, November 23, 2009
Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency.
31 Aug 2009 
Alpha-1-antitrypsin deficiency is a genetic condition associated with severe, early-onset chronic obstructive pulmonary disease (COPD). However, there is significant variability in lung function impairment among persons with the protease inhibitor ... Read more...
Genetics of COPD and emphysema.
30 Aug 2009 COPD is a highly prevalent disorder that results from the interplay of genetic susceptibility and environmental exposures. Over the past 2 decades, significant technological advances have been made in genetic investigations of complex diseases, yet ... Read more...
10 Aug 2009 Alpha-1 antitrypsin (AAT) deficiency is well-suited as a target for human gene transfer. We performed a phase 1, open-label, dose-escalation clinical trial of a recombinant adeno-associated virus (rAAV) vector expressing normal (M) AAT packaged into ... Read more...
Latest indexed articles for 'alpha 1-Antitrypsin Deficiency'
These are the very latest articles for this heading:
- [Genetics in chronic obstructive pulmonary disease]
20 Oct 2009 - Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency. 31 Aug 2009
- Genetics of COPD and emphysema. 30 Aug 2009
- Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. 10 Aug 2009
- Intravenous alpha1-antitrypsin in a child with deficiency and severe lung disease. 29 Jun 2009
- Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency.
29 Jun 2009 - Clinical practice. Alpha1-antitrypsin deficiency. 23 Jun 2009
- Hepatocellular carcinoma--epidemiological trends and risk factors. 20 Jun 2009
- [Alpha-1-antitrypsin deficiency: diagnosis and therapy of the lung disease] 8 Jun 2009
- Your racing horses will help you to quit: a lesson for COPD and alpha1-antitrypsin deficiency research. 30 May 2009
- [Mortality analysis of patients undergoing lung transplantation for emphysema] 18 May 2009
- alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies. 12 May 2009
- Lung volume reduction surgery for patients with alpha-1 antitrypsin deficiency emphysema. 29 Apr 2009
- Inherited metabolic disease of the liver. 29 Apr 2009
- [Alpha-1 antitrypsin deficiency. The experience of Pulido Valente Hospital with augmentation therapy] 29 Apr 2009
- COPD: new lessons from alpha1-antitrypsin deficiency? 29 Apr 2009
- Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency. 25 Apr 2009
- Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility report. 13 Apr 2009
- The impact of social contexts in testing for alpha-1 antitrypsin deficiency: the roles of physicians and others. 30 Mar 2009
- Reflections from the field regarding the clinical commentary for augmentation therapy in the MZ phenotype. 30 Mar 2009
See a longer list of these articles.
Technical information about 'alpha 1-Antitrypsin Deficiency'
Definition: Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN, leading primarily to degradation of elastin of the alveolar walls, as well as other structural proteins of a variety of tissues. (From Scriver, Beaudet, Sly, & Valle, The Metabolic and Molecular Bases of Inherited Disease, 7th ed, p4125)
Descriptor UI: D019896
Alternative terms: alpha 1-Antitrypsin Deficiency; Deficiencies, alpha 1-Antitrypsin; Deficiency, alpha 1-Antitrypsin; alpha 1 Antitrypsin Deficiency; alpha 1-Antitrypsin Deficiencies;
Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C17.300.050;
History Note: 98
Technical Notes: Pi or PiZZ goes here + PHENOTYPE; DF: ALPHA 1 ANTITRYPSIN DEFIC