alpha-Methyltyrosine - Pharmacology
Research News and Information

Sunday, November 22, 2009

Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion.

30 Aug 2009 OBJECTIVE: Previous positron emission tomography (PET) imaging studies have demonstrated that cocaine dependence is associated with a decrease in dopamine type 2 and 3 (D(2)/D(3)) receptor binding in cocaine-dependent individuals relative to healthy ... Read more...

Amphetamine-evoked rotation requires newly synthesized dopamine at 14 days but not 1 day after intranigral 6-OHDA and is consistently dissociated from sensorimotor behavior.

6 Jun 2009 Immediately after unilateral, intranigral 6-hydroxydopamine (6-OHDA), amphetamine (AMPH) evokes "paradoxical" contraversive rotation, whereas 14 days later, AMPH evokes the traditional ipsiversive rotation used to model the chronic Parkinsonian ... Read more...

Short-latency activation of striatal spiny neurons via subcortical visual pathways.

11 May 2009 The striatum is a site of integration of neural pathways involved in reinforcement learning. Traditionally, inputs from cerebral cortex are thought to be reinforced by dopaminergic afferents signaling the occurrence of biologically salient sensory ... Read more...

Latest indexed articles for 'alpha-Methyltyrosine - Pharmacology'

These are the very latest articles for this heading:

• Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion. 30 Aug 2009
• Amphetamine-evoked rotation requires newly synthesized dopamine at 14 days but not 1 day after intranigral 6-OHDA and is consistently dissociated from sensorimotor behavior. 6 Jun 2009
• Short-latency activation of striatal spiny neurons via subcortical visual pathways. 11 May 2009
• Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. 18 Mar 2009
• Accumbal noradrenaline that contributes to the alpha-adrenoceptor-mediated release of dopamine from reserpine-sensitive storage vesicles in the nucleus accumbens is derived from alpha-methyl-para-tyrosine-sensitive pools. 15 Feb 2009
• Sympathetic nervous system and lymphocyte proliferation in the Fischer 344 rat spleen: a longitudinal study. 24 Nov 2008
• The influence of catecholamine on the migration of gonadotropin-releasing hormone-producing neurons in the rat foetuses. 6 Oct 2008
• The rewarding efficacy of brain stimulation and its modulation by dopaminergic drugs in young adult and old BN F344F1 rats. 29 Sep 2008
• Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. 28 Sep 2008
• Recurrent inhibitory network among striatal cholinergic interneurons. 25 Aug 2008
• Interaction of dopamine, female pheromones, locomotion and sex behavior in Drosophila melanogaster. 7 Aug 2008
• Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype. 3 Aug 2008
• Evidence for dopamine involvement in ambulation promoted by menthone in mice. 29 Jul 2008
• Role of alpha2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice. 27 Jun 2008
• Effect of catecholamine depletion on increased blood pressure lability upon emergence from halothane anesthesia in rats: the role of sympathetic nervous activity in postanesthetic circulatory instability. 23 May 2008
• Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects. 29 Apr 2008
• Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. 14 Apr 2008
• The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats. Apr 2008
• Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems. 27 Mar 2008
• Prolactin secretion after hypothalamic deafferentation in beef calves: response to haloperidol, alpha-methyl-rho-tyrosine, thyrotropin-releasing hormone and ovariectomy. 11 Feb 2008

See a longer list of these articles.

Technical information about 'alpha-Methyltyrosine'

Definition: An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)

Registry Number: 658-48-0

Descriptor UI: D019805

Alternative terms: alpha-Methyltyrosine; alpha Methyltyrosine; alpha-Methyl-para-tyrosine; alpha Methyl para tyrosine; alpha-MPT; alpha MPT; alpha-Methyl-p-tyrosine; alpha Methyl p tyrosine; Demser; Merck Brand of Metyrosine; Metyrosine Merck Brand; Merck Sharp & Dohme Brand of Metyrosine; Racemetirosine; alpha-Methyltyrosine, (D,L)-Isomer; alpha-Methyltyrosine, (+,-)-Isomer; DL-Tyrosine, alpha-methyl-; alpha-methyl- DL-Tyrosine; alpha-Methyltyrosine Hydrochloride; Hydrochloride, alpha-Methyltyrosine; alpha Methyltyrosine Hydrochloride; Metyrosine; alpha-Methyltyrosine, (L)-Isomer; Metirosine;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Enzyme Inhibitors;

Tree Number: D12.125.072.050.875.485.050;

History Note: 98; use ALPHA-METHYLTYROSINE (NM) 1979-97