Alternative Splicing - Research News and Information

Wednesday, January 07, 2009

LKB1: cancer, polarity, metabolism, and now fertility.

13 Nov 2008 The LKB1 serine/threonine kinase is a tumour suppressor responsible for the inherited familial cancer disorder Peutz-Jeghers syndrome and is inactivated in a large percentage of human lung cancers. LKB1 acts a master kinase, directly ... Read more...

Identification of an expressed truncated form of CD200, CD200tr, which is a physiologic antagonist of CD200-induced suppression.

25 Oct 2008 BACKGROUND: Earlier studies have indicated that cell surface expressed CD200, or a soluble form of this molecule, can induce immunosuppression in a number of biological systems, and promote increased graft acceptance, after binding to receptors ... Read more...

VEGF-A splicing: the key to anti-angiogenic therapeutics?

14 Oct 2008 The physiology of microvessels limits the growth and development of tumours. Tumours gain nutrients and excrete waste through growth-associated microvessels. New anticancer therapies target this microvasculature by inhibiting vascular endothelial ... Read more...

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Latest indexed articles for 'Alternative Splicing'

These are the very latest articles for this heading:

• LKB1: cancer, polarity, metabolism, and now fertility. 13 Nov 2008
• Identification of an expressed truncated form of CD200, CD200tr, which is a physiologic antagonist of CD200-induced suppression. 25 Oct 2008
• VEGF-A splicing: the key to anti-angiogenic therapeutics? 14 Oct 2008
• Molecular biology: Bound to splice. 14 Oct 2008
• Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts. 13 Oct 2008
• Syntaxin 3b is a t-SNARE specific for ribbon synapses of the retina. 8 Oct 2008
• RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. 8 Oct 2008
• Cystitis is associated with TRPV1b-downregulation in rat dorsal root ganglia. 6 Oct 2008
• Promoter-sharing by different genes in human genome--CPNE1 and RBM12 gene pair as an example. Oct 2008
• Splice-mediated Variants of Proteins (SpliVaP) - data and characterization of changes in signatures among protein isoforms due to alternative splicing. 30 Sep 2008
• Identification of truncated chemokine receptor 7 in human colorectal cancer unable to localize to the cell surface and unreactive to external ligands. 29 Sep 2008
• Genotype-phenotype correlations in Rubinstein-Taybi syndrome. 29 Sep 2008
• Novel splice donor site mutation in MERTK gene associated with retinitis pigmentosa. 29 Sep 2008
• Gene symbol: MTM1. Disease: Myotubular myopathy. 29 Sep 2008
• Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition. 29 Sep 2008
• Analysis and classification of RNA tertiary structures. 27 Sep 2008
• Mutational analysis of the U12-dependent branch site consensus sequence. 27 Sep 2008
• Intronic Alus influence alternative splicing. 24 Sep 2008
• Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis. 22 Sep 2008
• Promoter-driven splicing regulation in fission yeast. 22 Sep 2008

See a longer list of these articles.

Technical information about 'Alternative Splicing'

Definition: A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.

Descriptor UI: D017398

Alternative terms: Alternative Splicing; Alternative Splicings; Splicings, Alternative; Alternate Splicing; Alternate Splicings; Splicing, Alternate; Splicings, Alternate; RNA Splicing, Alternative; Alternative RNA Splicing; Alternative RNA Splicings; RNA Splicings, Alternative; Splicing, Alternative RNA; Splicings, Alternative RNA; Splicing, Alternative; Nested Transcripts; Nested Transcript; Transcript, Nested; Transcripts, Nested;

Related Mesh Headings: Protein Isoforms; RNA Splice Sites; Nested Genes;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G02.111.087.750.700.100; G02.149.115.750.700.100; G03.495.839.700.100; G05.355.315.700.700.100;

History Note: 93

Technical Notes: for NESTED TRANSCRIPTS also index the RNA; do not confuse with NESTED GENES; for nested primers use NESTED PCR; (POLYMERASE CHAIN REACTION)