Alu Elements
Research News and Information

Sunday, November 22, 2009

Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA.

26 Aug 2009 In many cells, mRNAs containing inverted repeats (Alu repeats in humans) in their 3' untranslated regions (3'UTRs) are inefficiently exported to the cytoplasm. Nuclear retention correlates with adenosine-to-inosine editing and is in ... Read more...

A NEAT way of regulating nuclear export of mRNAs.

26 Aug 2009 In this issue of Molecular Cell, Chen and Carmichael (2009) demonstrate that the noncoding RNA NEAT1 regulates gene expression by restricting nuclear ... Read more...

Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements.

Aug 2009 Ehrlichiae are obligately intracellular bacteria that reside and replicate in phagocytes by circumventing host cell defenses and modulating cellular processes, including host cell gene transcription. However, the mechanisms by which ehrlichiae ... Read more...

Latest indexed articles for 'Alu Elements'

These are the very latest articles for this heading:

• Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA. 26 Aug 2009
• A NEAT way of regulating nuclear export of mRNAs. 26 Aug 2009
• Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements. Aug 2009
• Small polydispersed circular DNA contains strains of mobile genetic elements and occurs more frequently in permanent cell lines of malignant tumors than in normal lymphocytes. 30 Jul 2009
• Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer. 30 Jul 2009
• Widespread cleavage of A-to-I hyperediting substrates. 19 Jul 2009
• Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates. 14 Jul 2009
• Rare pathogenic microdeletions and tandem duplications are microhomology-mediated and stimulated by local genomic architecture. Jul 2009
• Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution. 24 Jun 2009
• Differential repetitive DNA methylation in multiple myeloma molecular subgroups. 14 Jun 2009
• Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. 6 Jun 2009
• When new exons are born. Jun 2009
• A novel protein isoform of the multicopy human NAIP gene derives from intragenic Alu SINE promoters. 31 May 2009
• Autografts and xenografts of skin fibroblasts delivering BMP-2 effectively promote orthotopic and ectopic osteogenesis. 30 May 2009
• Single particle adsorbing transfer system. 30 May 2009
• Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. 27 May 2009
• Physical function is weakly associated with angiotensin-converting enzyme gene I/D polymorphism in elderly Japanese subjects. 26 May 2009
• High-throughput sequence-based epigenomic analysis of Alu repeats in human cerebellum. 18 May 2009
• Source gene composition and gene conversion of the AluYh and AluYi lineages of retrotransposons. 12 May 2009
• Comparative analysis of Alu repeats in primate genomes. 29 Apr 2009

See a longer list of these articles.

Technical information about 'Alu Elements'

Definition: The Alu sequence family (named for the restriction endonuclease cleavage enzyme Alu I) is the most highly repeated interspersed repeat element in humans (over a million copies). It is derived from the 7SL RNA component of the SIGNAL RECOGNITION PARTICLE and contains an RNA polymerase III promoter. Transposition of this element into coding and regulatory regions of genes is responsible for many heritable diseases.

Descriptor UI: D020087

Alternative terms: Alu Elements; Alu Element; Element, Alu; Elements, Alu; Alu Family; Alu Families; Families, Alu; Family, Alu; Alu Repetitive Sequences; Alu Repetitive Sequence; Repetitive Sequence, Alu; Repetitive Sequences, Alu; Sequence, Alu Repetitive; Sequences, Alu Repetitive; Alu-Like Repetitive Sequence;

Related Mesh Headings: Mutagenesis, Insertional;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G02.111.570.080.708.330.800.800.050; G05.360.080.708.330.800.800.050; G05.360.340.024.425.800.800.050;

History Note: 99; use REPETITIVE SEQUENCES, NUCLEIC ACID 1988-98; for ALU REPETITIVE SEQUENCE, ALU FAMILY, and ALU-LIKE REPETITIVE SEQUENCE use REPETITIVE SEQUENCES, NUCLEIC ACID 1988-98