Alzheimer Disease - Epidemiology
Research News and Information

Saturday, November 21, 2009

Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease.

30 Oct 2009 CONTEXT: Alzheimer disease (AD) is a complex disorder with a strong heritable component. Amyloid pathology, vascular factors, and inflammation are postulated to be involved in its pathogenesis, but causality has not been established unequivocally. ... Read more...

Implication of sex and SORL1 variants in italian patients with Alzheimer disease.

29 Sep 2009 OBJECTIVE: To investigate the association of genetic variants in sortilin-related receptor (SORL1), which has been proposed as an important genetic contributor to late-onset Alzheimer disease (LOAD). DESIGN: We analyzed 13 SORL1 single-nucleotide ... Read more...

Longitudinal study of the transition from healthy aging to Alzheimer disease.

29 Sep 2009 BACKGROUND: Detection of the earliest cognitive changes signifying Alzheimer disease is difficult. OBJECTIVE: To model the cognitive decline in preclinical Alzheimer disease. DESIGN: Longitudinal archival study comparing individuals who became ... Read more...

Latest indexed articles for 'Alzheimer Disease - Epidemiology'

These are the very latest articles for this heading:

• Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. 30 Oct 2009
• Implication of sex and SORL1 variants in italian patients with Alzheimer disease. 29 Sep 2009
• Longitudinal study of the transition from healthy aging to Alzheimer disease. 29 Sep 2009
• Promising strategies for the prevention of dementia. 29 Sep 2009
• Stroke and dementia. 29 Sep 2009
• Does IgG therapy prevent Alzheimer's disease? 30 Aug 2009
• Extrapyramidal signs before and after diagnosis of incident Alzheimer disease in a prospective population study. 30 Aug 2009
• Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease. 30 Aug 2009
• Genetic interaction between tau and the apolipoprotein E receptor LRP1 Increases Alzheimer's disease risk. 11 Aug 2009
• Mediterranean diet and late-life cognitive impairment: a taste of benefit. 10 Aug 2009
• Physical activity, diet, and risk of Alzheimer disease. 10 Aug 2009
• Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later. 2 Aug 2009
• [Oldest-old dementia in a Japanese memory clinic] 30 Jul 2009
• The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset? 30 Jul 2009
• Dementia: the bare essentials. 30 Jul 2009
• Depressed mood is not a risk factor for incident dementia in a community-based cohort. 30 Jul 2009
• States take on Alzheimer's disease. 30 Jul 2009
• Seizures in Alzheimer disease: who, when, and how common? 30 Jul 2009
• Association between a genetic variant of the alpha-7 nicotinic acetylcholine receptor subunit and four types of dementia. 27 Jul 2009
• Superficial siderosis in the general population. 19 Jul 2009

See a longer list of these articles.

Technical information about 'Alzheimer Disease'

Definition: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Descriptor UI: D000544

Alternative terms: Alzheimer Disease; Disease, Alzheimer; Dementia, Senile; Dementias, Senile; Senile Dementia; Senile Dementias; Dementia, Primary Senile Degenerative; Senile Dementia, Alzheimer Type; Alzheimer Type Senile Dementia; Primary Senile Degenerative Dementia; Alzheimer's Disease; Disease, Alzheimer's; Dementia, Alzheimer Type; Alzheimer Type Dementia; Dementia, Presenile; Dementias, Presenile; Presenile Dementia; Presenile Dementias; Alzheimer Disease, Late Onset; Late Onset Alzheimer Disease; Alzheimer's Disease, Focal Onset; Focal Onset Alzheimer's Disease; Acute Confusional Senile Dementia; Senile Dementia, Acute Confusional; Alzheimer Disease, Early Onset; Early Onset Alzheimer Disease; Presenile Alzheimer Dementia; Alzheimer Dementia, Presenile; Dementia, Presenile Alzheimer;

Related Mesh Headings: Amyloid beta-Protein; Amyloid beta-Protein Precursor; Cerebral Amyloid Angiopathy; tau Proteins; Neurofilament Proteins; Aphasia, Primary Progressive; Kluver-Bucy Syndrome;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.228.140.380.100; C10.574.945.249; F03.087.400.100;

History Note: 1998(1963); for DEMENTIA, PRESENILE and DEMENTIA, PRIMARY DEGENERATIVE SENILE use DEMENTIA 1981-1999; for DEMENTIA SENILE use DEMENTIA 1966-1999