Alzheimer Disease - Etiology
Research News and Information

Sunday, November 22, 2009

Stroke and dementia.

29 Sep 2009 OBJECTIVE: The current review covers causes and risk factors of vascular dementia, including single infarct, multi-infarct and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Comparisons and distinctions ... Read more...

Amyloid-beta(1-42) fibrillar precursors are optimal for inducing tumor necrosis factor-alpha production in the THP-1 human monocytic cell line.

27 Sep 2009 Pathological studies have determined that fibrillar forms of amyloid-beta protein (Abeta) comprise the characteristic neuritic plaques in Alzheimer's disease (AD). These studies have also revealed significant inflammatory markers such as activated ... Read more...

Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits.

16 Sep 2009 The importance of DNA repair in the pathogenic mechanism of Alzheimer's Disease (AD) is still poorly understood. Here, we report that a broad range of responses by DNA repair proteins plays a critical role in the regulation of inflammatory response ... Read more...

Latest indexed articles for 'Alzheimer Disease - Etiology'

These are the very latest articles for this heading:

• Longitudinal Alzheimer's studies go global. 14 Oct 2009
• A multi-targeted approach for a complex multifaceted disease. 29 Sep 2009
• Stroke and dementia. 29 Sep 2009
• Amyloid-beta(1-42) fibrillar precursors are optimal for inducing tumor necrosis factor-alpha production in the THP-1 human monocytic cell line. 27 Sep 2009
• Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits. 16 Sep 2009
• Reelin signaling antagonizes beta-amyloid at the synapse. 31 Aug 2009
• Treatment of vascular risk factors is associated with slower decline in Alzheimer disease. 30 Aug 2009
• Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice. 12 Aug 2009
• Evaluation of cognitive impairment attributable to microvascular damage. 30 Jul 2009
• Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes. 14 Jul 2009
• Ca(2+), within the physiological concentrations, selectively accelerates Abeta42 fibril formation and not Abeta40 in vitro. 8 Jul 2009
• Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study. 6 Jul 2009
• Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies. 29 Jun 2009
• The role of RAGE in amyloid-beta peptide-mediated pathology in Alzheimer's disease. 29 Jun 2009
• Carotid artery ultrasound and echocardiography testing to lower the prevalence of Alzheimer's disease. 29 Jun 2009
• Transcriptional regulation of the murine Presenilin-2 gene reveals similarities and differences to its human orthologue. 28 Jun 2009
• Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications. 21 Jun 2009
• Contribution of neural networks to Alzheimer disease's progression. 15 Jun 2009
• Nitric oxide activity and isoenzyme expression in the senescence-accelerated mouse p8 model of Alzheimer's disease: effects of anti-amyloid antibody and antisense treatments. 14 Jun 2009
• [Management and therapy of Alzheimer's disease. Recommendations of a general practitioners' guideline] 9 Jun 2009

See a longer list of these articles.

Technical information about 'Alzheimer Disease'

Definition: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Descriptor UI: D000544

Alternative terms: Alzheimer Disease; Disease, Alzheimer; Dementia, Senile; Dementias, Senile; Senile Dementia; Senile Dementias; Dementia, Primary Senile Degenerative; Senile Dementia, Alzheimer Type; Alzheimer Type Senile Dementia; Primary Senile Degenerative Dementia; Alzheimer's Disease; Disease, Alzheimer's; Dementia, Alzheimer Type; Alzheimer Type Dementia; Dementia, Presenile; Dementias, Presenile; Presenile Dementia; Presenile Dementias; Alzheimer Disease, Late Onset; Late Onset Alzheimer Disease; Alzheimer's Disease, Focal Onset; Focal Onset Alzheimer's Disease; Acute Confusional Senile Dementia; Senile Dementia, Acute Confusional; Alzheimer Disease, Early Onset; Early Onset Alzheimer Disease; Presenile Alzheimer Dementia; Alzheimer Dementia, Presenile; Dementia, Presenile Alzheimer;

Related Mesh Headings: Amyloid beta-Protein; Amyloid beta-Protein Precursor; Cerebral Amyloid Angiopathy; tau Proteins; Neurofilament Proteins; Aphasia, Primary Progressive; Kluver-Bucy Syndrome;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.228.140.380.100; C10.574.945.249; F03.087.400.100;

History Note: 1998(1963); for DEMENTIA, PRESENILE and DEMENTIA, PRIMARY DEGENERATIVE SENILE use DEMENTIA 1981-1999; for DEMENTIA SENILE use DEMENTIA 1966-1999