Alzheimer Disease - Genetics
Research News and Information

Sunday, November 22, 2009

Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease.

30 Oct 2009 CONTEXT: Alzheimer disease (AD) is a complex disorder with a strong heritable component. Amyloid pathology, vascular factors, and inflammation are postulated to be involved in its pathogenesis, but causality has not been established unequivocally. ... Read more...

G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease.

18 Oct 2009 The beta-amyloid (Abeta) peptide is associated with the pathogenesis of Alzheimer's disease (AD). Evidence gathered over the last two decades suggests that the gradual accumulation of soluble and insoluble Abeta peptide species triggers a cascade of ... Read more...

A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice.

5 Oct 2009 Although neuronal communication is thought to be summated within local dendritic segments, no technique is currently available to monitor activity in vivo at this level of resolution. To overcome this challenge, we developed an optical reporter of ... Read more...

Latest indexed articles for 'Alzheimer Disease - Genetics'

These are the very latest articles for this heading:

• Beyond proof of principle: new genes for Alzheimer's disease through collaboration. 30 Oct 2009
• Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. 30 Oct 2009
• G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease. 18 Oct 2009
• A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. 5 Oct 2009
• A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease. 29 Sep 2009
• Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches. 29 Sep 2009
• A multi-targeted approach for a complex multifaceted disease. 29 Sep 2009
• [Effects of auricular acupuncture on the memory and the expression of ChAT and GFAP in model rats with Alzheimer's disease] 29 Sep 2009
• Implication of sex and SORL1 variants in italian patients with Alzheimer disease. 29 Sep 2009
• Codistribution of amyloid beta plaques and spongiform degeneration in familial Creutzfeldt-Jakob disease with the E200K-129M haplotype. 29 Sep 2009
• Your genetic makeup is an Alzheimer's risk predictor. If you know you carry a gene that boosts your risk of AD, you may make better decisions about your future. 29 Sep 2009
• Alzheimer's disease beyond APOE. 29 Sep 2009
• [The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain] 28 Sep 2009
• A simple and efficient algorithm for genome-wide homozygosity analysis in disease. 13 Sep 2009
• HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q. 13 Sep 2009
• Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. 8 Sep 2009
• Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease. 6 Sep 2009
• Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. 4 Sep 2009
• Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. 4 Sep 2009
• Tumour necrosis factor modulation for treatment of Alzheimer's disease: rationale and current evidence. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Alzheimer Disease'

Definition: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Descriptor UI: D000544

Alternative terms: Alzheimer Disease; Disease, Alzheimer; Dementia, Senile; Dementias, Senile; Senile Dementia; Senile Dementias; Dementia, Primary Senile Degenerative; Senile Dementia, Alzheimer Type; Alzheimer Type Senile Dementia; Primary Senile Degenerative Dementia; Alzheimer's Disease; Disease, Alzheimer's; Dementia, Alzheimer Type; Alzheimer Type Dementia; Dementia, Presenile; Dementias, Presenile; Presenile Dementia; Presenile Dementias; Alzheimer Disease, Late Onset; Late Onset Alzheimer Disease; Alzheimer's Disease, Focal Onset; Focal Onset Alzheimer's Disease; Acute Confusional Senile Dementia; Senile Dementia, Acute Confusional; Alzheimer Disease, Early Onset; Early Onset Alzheimer Disease; Presenile Alzheimer Dementia; Alzheimer Dementia, Presenile; Dementia, Presenile Alzheimer;

Related Mesh Headings: Amyloid beta-Protein; Amyloid beta-Protein Precursor; Cerebral Amyloid Angiopathy; tau Proteins; Neurofilament Proteins; Aphasia, Primary Progressive; Kluver-Bucy Syndrome;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.228.140.380.100; C10.574.945.249; F03.087.400.100;

History Note: 1998(1963); for DEMENTIA, PRESENILE and DEMENTIA, PRIMARY DEGENERATIVE SENILE use DEMENTIA 1981-1999; for DEMENTIA SENILE use DEMENTIA 1966-1999