Alzheimer Disease - Pathology
Research News and Information

Saturday, November 21, 2009

High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patients.

6 Dec 2009 The main objective of this study was to determine whether elevated blood beta-amyloid (Abeta) levels among the first-degree relatives of patients with Alzheimer's Disease (AD) are associated with vascular risk factors of AD. Serum Abeta was measured ... Read more...

Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway.

29 Nov 2009 Calcium/calmodulin-dependent protein kinase IV (CaMKIV) plays a key role in the regulation of calcium-dependent gene expression. The expression of CaMKIV and the activation of CREB regulated genes are involved in memory and neuronal survival. We ... Read more...

Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.

12 Oct 2009 In Alzheimer's disease (AD), rod-like cofilin aggregates (cofilin-actin rods) and thread-like inclusions containing phosphorylated microtubule-associated protein (pMAP) tau form in the brain (neuropil threads), and the extent of their presence ... Read more...

Latest indexed articles for 'Alzheimer Disease - Pathology'

These are the very latest articles for this heading:

• High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patients. 6 Dec 2009
• Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway. 29 Nov 2009
• Longitudinal Alzheimer's studies go global. 14 Oct 2009
• Alzheimer's biomarker initiative hits its stride. 14 Oct 2009
• Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. 12 Oct 2009
• Alzheimer's disease affects progenitor cells through aberrant {beta}-catenin signaling. 5 Oct 2009
• Tau-focused immunotherapy for Alzheimer's disease and related tauopathies. 29 Sep 2009
• Lysosomal modulatory drugs for a broad strategy against protein accumulation disorders. 29 Sep 2009
• Hypoxia and neurodegeneration. 29 Sep 2009
• Longitudinal study of the transition from healthy aging to Alzheimer disease. 29 Sep 2009
• Codistribution of amyloid beta plaques and spongiform degeneration in familial Creutzfeldt-Jakob disease with the E200K-129M haplotype. 29 Sep 2009
• Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. 29 Sep 2009
• Potential roles of cell-derived microparticles in ischemic brain disease. 29 Sep 2009
• [Final report is now available. IQWiG doubts the effectiveness of memantine] 22 Sep 2009
• Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism. 21 Sep 2009
• Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease. 20 Sep 2009
• Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits. 16 Sep 2009
• Identification and characterisation of the novel amyloid-beta peptide-induced protein p17. 11 Sep 2009
• Age, neuropathology, and dementia. 8 Sep 2009
• Isn't amyloid more than just a marker for Alzheimer disease? 7 Sep 2009

See a longer list of these articles.

Technical information about 'Alzheimer Disease'

Definition: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Descriptor UI: D000544

Alternative terms: Alzheimer Disease; Disease, Alzheimer; Dementia, Senile; Dementias, Senile; Senile Dementia; Senile Dementias; Dementia, Primary Senile Degenerative; Senile Dementia, Alzheimer Type; Alzheimer Type Senile Dementia; Primary Senile Degenerative Dementia; Alzheimer's Disease; Disease, Alzheimer's; Dementia, Alzheimer Type; Alzheimer Type Dementia; Dementia, Presenile; Dementias, Presenile; Presenile Dementia; Presenile Dementias; Alzheimer Disease, Late Onset; Late Onset Alzheimer Disease; Alzheimer's Disease, Focal Onset; Focal Onset Alzheimer's Disease; Acute Confusional Senile Dementia; Senile Dementia, Acute Confusional; Alzheimer Disease, Early Onset; Early Onset Alzheimer Disease; Presenile Alzheimer Dementia; Alzheimer Dementia, Presenile; Dementia, Presenile Alzheimer;

Related Mesh Headings: Amyloid beta-Protein; Amyloid beta-Protein Precursor; Cerebral Amyloid Angiopathy; tau Proteins; Neurofilament Proteins; Aphasia, Primary Progressive; Kluver-Bucy Syndrome;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.228.140.380.100; C10.574.945.249; F03.087.400.100;

History Note: 1998(1963); for DEMENTIA, PRESENILE and DEMENTIA, PRIMARY DEGENERATIVE SENILE use DEMENTIA 1981-1999; for DEMENTIA SENILE use DEMENTIA 1966-1999