Alzheimer Disease - Physiopathology
Research News and Information

Saturday, November 21, 2009

Taking advantage of the systemic immune system to cure brain diseases.

13 Oct 2009 The systemic immune system has the ability to modulate multiple brain functions, including autonomic responses, glial reactivity following neural injuries, and neuronal excitability. Immune stimuli also influence microglia subpopulations originating ... Read more...

[Pain assessment in dementia]

6 Oct 2009 BACKGROUND: Patients with dementia are often unable to describe their pain because of memory deficiency and speech problems. This may lead to under-diagnosing and suboptimal pain treatment. The article summarises a thesis on development and testing ... Read more...

Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies.

4 Oct 2009 BACKGROUND: Recent studies raised questions about the severity of cognitive impairment associated with dementia with Lewy bodies (DLB). However, there have been few analyses of large, multicenter data registries for clinical-pathologic correlation. ... Read more...

Latest indexed articles for 'Alzheimer Disease - Physiopathology'

These are the very latest articles for this heading:

• Taking advantage of the systemic immune system to cure brain diseases. 13 Oct 2009
• [Pain assessment in dementia] 6 Oct 2009
• Alzheimer's disease affects progenitor cells through aberrant {beta}-catenin signaling. 5 Oct 2009
• Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies. 4 Oct 2009
• Atypical antipsychotics in the elderly: a review of therapeutic trends and clinical outcomes. 29 Sep 2009
• The Coalition Against Major Diseases: developing tools for an integrated drug development process for Alzheimer's and Parkinson's diseases. 29 Sep 2009
• Potential roles of cell-derived microparticles in ischemic brain disease. 29 Sep 2009
• Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease. 20 Sep 2009
• Reelin signaling antagonizes beta-amyloid at the synapse. 31 Aug 2009
• Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain. 31 Aug 2009
• Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. 30 Aug 2009
• Tumour necrosis factor modulation for treatment of Alzheimer's disease: rationale and current evidence. 30 Aug 2009
• Defining and labeling disease-modifying treatments for Alzheimer's disease. 30 Aug 2009
• Novel therapeutics based on tau/microtubule dynamics: WO2008084483. 30 Aug 2009
• Extrapyramidal signs before and after diagnosis of incident Alzheimer disease in a prospective population study. 30 Aug 2009
• Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression. 30 Aug 2009
• Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial). 30 Aug 2009
• Akinetopsia in the posterior cortical variant of Alzheimer disease. 30 Aug 2009
• Parental history of Alzheimer disease associated with lower plasma apolipoprotein E levels. 30 Aug 2009
• Treatment of vascular risk factors is associated with slower decline in Alzheimer disease. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Alzheimer Disease'

Definition: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Descriptor UI: D000544

Alternative terms: Alzheimer Disease; Disease, Alzheimer; Dementia, Senile; Dementias, Senile; Senile Dementia; Senile Dementias; Dementia, Primary Senile Degenerative; Senile Dementia, Alzheimer Type; Alzheimer Type Senile Dementia; Primary Senile Degenerative Dementia; Alzheimer's Disease; Disease, Alzheimer's; Dementia, Alzheimer Type; Alzheimer Type Dementia; Dementia, Presenile; Dementias, Presenile; Presenile Dementia; Presenile Dementias; Alzheimer Disease, Late Onset; Late Onset Alzheimer Disease; Alzheimer's Disease, Focal Onset; Focal Onset Alzheimer's Disease; Acute Confusional Senile Dementia; Senile Dementia, Acute Confusional; Alzheimer Disease, Early Onset; Early Onset Alzheimer Disease; Presenile Alzheimer Dementia; Alzheimer Dementia, Presenile; Dementia, Presenile Alzheimer;

Related Mesh Headings: Amyloid beta-Protein; Amyloid beta-Protein Precursor; Cerebral Amyloid Angiopathy; tau Proteins; Neurofilament Proteins; Aphasia, Primary Progressive; Kluver-Bucy Syndrome;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.228.140.380.100; C10.574.945.249; F03.087.400.100;

History Note: 1998(1963); for DEMENTIA, PRESENILE and DEMENTIA, PRIMARY DEGENERATIVE SENILE use DEMENTIA 1981-1999; for DEMENTIA SENILE use DEMENTIA 1966-1999