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Alzheimer Disease - Radionuclide imaging
Research News and Information
Definition of 'Alzheimer Disease'A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) |
Monday, November 23, 2009
Relationships between biomarkers in aging and dementia.
11 Oct 2009 
BACKGROUND: PET imaging using [(18)F]fluorodeoxyglucose (FDG) and [(11)C]Pittsburgh compound B (PIB) have been proposed as biomarkers of Alzheimer disease (AD), as have CSF measures of the 42 amino acid beta-amyloid protein (Abeta(1-42)) and total ... Read more...
14 Sep 2009 Neuroimaging is increasingly used to supplement the clinical diagnosis of dementia with Lewy bodies (DLB) by showing reduced occipital metabolism and perfusion and reduced striatal dopaminergic innervation. We aimed to optimize the interpretation of ... Read more...
Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls.
31 Aug 2009 OBJECTIVE: In Alzheimer disease (AD), the accumulation pattern of beta-amyloid over time and its relationship with dementia severity are unclear. We investigated the brain uptake of the amyloid ligand (11)C-labeled Pittsburgh compound B ([(11)C]PIB) ... Read more...
Latest indexed articles for 'Alzheimer Disease - Radionuclide imaging'
These are the very latest articles for this heading:
- Relationships between biomarkers in aging and dementia. 11 Oct 2009
- The 18F-FDG PET cingulate island sign and comparison to 123I-beta-CIT SPECT for diagnosis of dementia with Lewy bodies. 14 Sep 2009
- Isn't amyloid more than just a marker for Alzheimer disease?
7 Sep 2009 - Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls. 31 Aug 2009
- Update on amyloid imaging: from healthy aging to Alzheimer's disease. 30 Aug 2009
- SVM-based CAD system for early detection of the Alzheimer's disease using kernel PCA and LDA. 26 Aug 2009
- Imaging and biomarkers in early Alzheimer's disease and mild cognitive impairment. 24 Aug 2009
- Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding. 16 Aug 2009
- 123I-5-IA-85380 SPECT imaging of nicotinic receptors in Alzheimer disease and mild cognitive impairment. 16 Aug 2009
- Regional distribution and behavioral correlates of 5-HT(2A) receptors in Alzheimer's disease with [(18)F]deuteroaltanserin and PET. 11 Aug 2009
- [Positron emission tomography: contribution to diagnosis of dementia and development of disease-modifying drugs] 30 Jul 2009
- Mapping brain beta-amyloid. 30 Jul 2009
- Amyloid + activation = Alzheimer's? 28 Jul 2009
- Amyloid imaging in the prediction of Alzheimer-type dementia in subjects with amnestic MCI. 27 Jul 2009
- Dissecting molecular mechanisms in the living brain of dementia patients. 19 Jul 2009
- Altered brain serotonin transporter and associated glucose metabolism in Alzheimer disease. 15 Jul 2009
- Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease. 15 Jul 2009
- Alzheimer's disease and corticobasal degeneration presenting as corticobasal syndrome. 13 Jul 2009
- Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility. 6 Jul 2009
- Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study. 6 Jul 2009
See a longer list of these articles.
Technical information about 'Alzheimer Disease'
Definition: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Descriptor UI: D000544
Alternative terms: Alzheimer Disease; Disease, Alzheimer; Dementia, Senile; Dementias, Senile; Senile Dementia; Senile Dementias; Dementia, Primary Senile Degenerative; Senile Dementia, Alzheimer Type; Alzheimer Type Senile Dementia; Primary Senile Degenerative Dementia; Alzheimer's Disease; Disease, Alzheimer's; Dementia, Alzheimer Type; Alzheimer Type Dementia; Dementia, Presenile; Dementias, Presenile; Presenile Dementia; Presenile Dementias; Alzheimer Disease, Late Onset; Late Onset Alzheimer Disease; Alzheimer's Disease, Focal Onset; Focal Onset Alzheimer's Disease; Acute Confusional Senile Dementia; Senile Dementia, Acute Confusional; Alzheimer Disease, Early Onset; Early Onset Alzheimer Disease; Presenile Alzheimer Dementia; Alzheimer Dementia, Presenile; Dementia, Presenile Alzheimer;
Related Mesh Headings: Amyloid beta-Protein; Amyloid beta-Protein Precursor; Cerebral Amyloid Angiopathy; tau Proteins; Neurofilament Proteins; Aphasia, Primary Progressive; Kluver-Bucy Syndrome;
Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C10.228.140.380.100; C10.574.945.249; F03.087.400.100;
History Note: 1998(1963); for DEMENTIA, PRESENILE and DEMENTIA, PRIMARY DEGENERATIVE SENILE use DEMENTIA 1981-1999; for DEMENTIA SENILE use DEMENTIA 1966-1999