Alzheimer Disease
Research News and Information

Friday, November 20, 2009

High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patients.

6 Dec 2009 The main objective of this study was to determine whether elevated blood beta-amyloid (Abeta) levels among the first-degree relatives of patients with Alzheimer's Disease (AD) are associated with vascular risk factors of AD. Serum Abeta was measured ... Read more...

Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway.

29 Nov 2009 Calcium/calmodulin-dependent protein kinase IV (CaMKIV) plays a key role in the regulation of calcium-dependent gene expression. The expression of CaMKIV and the activation of CREB regulated genes are involved in memory and neuronal survival. We ... Read more...

Surface plasmon resonance binding kinetics of Alzheimer's disease amyloid beta peptide-capturing and plaque-binding monoclonal antibodies.

Nov 2009 Several different monoclonal antibodies (mAbs) have been actively developed in the field of Alzheimer's disease (AD) for basic science and clinical applications; however, the binding kinetics of many of the mAbs with the beta-amyloid peptides ... Read more...

Latest indexed articles for 'Alzheimer Disease'

These are the very latest articles for this heading:

• High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patients. 6 Dec 2009
• Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway. 29 Nov 2009
• Surface plasmon resonance binding kinetics of Alzheimer's disease amyloid beta peptide-capturing and plaque-binding monoclonal antibodies. Nov 2009
• Donepezil treatment of patients with MCI: a 48-week randomized, placebo- controlled trial. Nov 2009
• The concentration and persistence of health care expenditures and prescription drug expenditures in Medicare beneficiaries with Alzheimer disease and related dementias. 30 Oct 2009
• Beyond proof of principle: new genes for Alzheimer's disease through collaboration. 30 Oct 2009
• Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. 30 Oct 2009
• DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model. 26 Oct 2009
• G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease. 18 Oct 2009
• Longitudinal Alzheimer's studies go global. 14 Oct 2009
• Alzheimer's biomarker initiative hits its stride. 14 Oct 2009
• Taking advantage of the systemic immune system to cure brain diseases. 13 Oct 2009
• The clinical course of advanced dementia. 13 Oct 2009
• Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. 12 Oct 2009
• Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. 12 Oct 2009
• The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. 12 Oct 2009
• Relationships between biomarkers in aging and dementia. 11 Oct 2009
• Adverse events in patients receiving cholinesterase inhibitors due to dissimilar follow-up periods. 10 Oct 2009
• [Pain assessment in dementia] 6 Oct 2009
• A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. 5 Oct 2009

See a longer list of these articles.

Technical information about 'Alzheimer Disease'

Definition: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Descriptor UI: D000544

Alternative terms: Alzheimer Disease; Disease, Alzheimer; Dementia, Senile; Dementias, Senile; Senile Dementia; Senile Dementias; Dementia, Primary Senile Degenerative; Senile Dementia, Alzheimer Type; Alzheimer Type Senile Dementia; Primary Senile Degenerative Dementia; Alzheimer's Disease; Disease, Alzheimer's; Dementia, Alzheimer Type; Alzheimer Type Dementia; Dementia, Presenile; Dementias, Presenile; Presenile Dementia; Presenile Dementias; Alzheimer Disease, Late Onset; Late Onset Alzheimer Disease; Alzheimer's Disease, Focal Onset; Focal Onset Alzheimer's Disease; Acute Confusional Senile Dementia; Senile Dementia, Acute Confusional; Alzheimer Disease, Early Onset; Early Onset Alzheimer Disease; Presenile Alzheimer Dementia; Alzheimer Dementia, Presenile; Dementia, Presenile Alzheimer;

Related Mesh Headings: Amyloid beta-Protein; Amyloid beta-Protein Precursor; Cerebral Amyloid Angiopathy; tau Proteins; Neurofilament Proteins; Aphasia, Primary Progressive; Kluver-Bucy Syndrome;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.228.140.380.100; C10.574.945.249; F03.087.400.100;

History Note: 1998(1963); for DEMENTIA, PRESENILE and DEMENTIA, PRIMARY DEGENERATIVE SENILE use DEMENTIA 1981-1999; for DEMENTIA SENILE use DEMENTIA 1966-1999