Amantadine - Research News and Information

Wednesday, January 07, 2009

Placebo-controlled trial of 400 mg amantadine combined with peginterferon alfa-2a and ribavirin for 48 weeks in chronic hepatitis C virus-1 infection.

30 Oct 2008 The impact of amantadine on virologic response rates of interferon-based treatment of chronic hepatitis C is controversial. The aim of this study was to compare virological response rates in patients with chronic hepatitis C virus (HCV)-1 infection ... Read more...

Antivirals and influenza: frequency of resistance.

29 Sep 2008 Antivirals are effective in prophylaxis and therapy for influenza and are likely to be active against a new pandemic variant. They can be divided into the M2 inhibitors, adamantane and rimantadine, and the neuraminidase inhibitors (NAIs), zanamivir ... Read more...

Clathrin- and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin.

30 Aug 2008 Feline infectious peritonitis virus (FIPV), a coronavirus that causes a lethal chronic disease in cats, enters feline monocytes via endocytosis. In this study, the pathway of internalization is characterized by evaluating the effect of chemical ... Read more...

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Latest indexed articles for 'Amantadine'

These are the very latest articles for this heading:

• Placebo-controlled trial of 400 mg amantadine combined with peginterferon alfa-2a and ribavirin for 48 weeks in chronic hepatitis C virus-1 infection. 30 Oct 2008
• Antivirals and influenza: frequency of resistance. 29 Sep 2008
• Clathrin- and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin. 30 Aug 2008
• Cardiotoxicity after massive amantadine overdose. 30 Aug 2008
• Efficacy of interferon based antiviral therapy for recurrent hepatitis C in patients who received steroid free immunosuppression for liver transplantation. 13 Aug 2008
• Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. 29 Jul 2008
• Design and synthesis of bioactive 1,2-annulated adamantane derivatives. 7 Jul 2008
• Initiating influenza chemoprophylaxis with the first influenza case: a new institutional standard? 29 Jun 2008
• Effect of timing of amantadine chemoprophylaxis on severity of outbreaks of influenza a in adult long-term care facilities. 29 Jun 2008
• The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. 29 Jun 2008
• Influenza in Canada: 2007-2008 season update. 29 Jun 2008
• Emergence and phylogenetic relationships of amantadine-resistant human H3N2 influenza A viruses in Germany in the season 2005/2006. 18 Jun 2008
• Antiviral drugs for the control of pandemic influenza virus. 30 May 2008
• Fatal intoxication using amantadine and pramipexole in a uremic patient. 30 May 2008
• Amantadine-associated corneal edema potentially irreversible even after cessation of the medication. 21 May 2008
• A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine. 12 May 2008
• Synthesis and ITC characterization of novel nanoparticles constituted by poly(gamma-benzyl L-glutamate)-beta-cyclodextrin. 29 Apr 2008
• High incidence of amantadine-resistant influenza H1N1 viruses isolated during the 2007-2008 season in Nara Prefecture, Japan. 29 Apr 2008
• Do pediatricians manage influenza differently than internists? 22 Apr 2008
• Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus. 9 Apr 2008

See a longer list of these articles.

Technical information about 'Amantadine'

Definition: An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

Chemical name: Tricyclo(3.3.1.13,7)decan-1-amine

Registry Number: 768-94-5

Descriptor UI: D000547

Alternative terms: Amantadine; Adamantylamine; 1-Aminoadamantane; 1 Aminoadamantane; Amantadin-neuraxpharm; Amantadin neuraxpharm; Amantadinneuraxpharm; neuraxpharm Brand of Amantadine Sulfate; Amantadina Llorente; Llorente, Amantadina; Llorente Brand of Amantadine Hydrochloride; Amantadine Hydrochloride; Hydrochloride, Amantadine; Amantadine Sulfate; Sulfate, Amantadine; Amixx; Krewel Brand of Amantadine Hydrochloride; Cerebramed; Orion Brand of Amantadine Hydrochloride; Gen-Amantadine; Gen Amantadine; GenAmantadine; Genpharm Brand of Amantadine Hydrochloride; Infecto-Flu; Infecto Flu; InfectoFlu; Infectopharm Brand of Amantadine Hydrochloride; Infex; Merz Brand of Amantadine Sulfate; Midantan; PMS-Amantadine; PMS Amantadine; PMSAmantadine; Pharmascience Brand of Amantadine Hydrochloride; Symadine; Solvay Brand of Amantadine Hydrochloride; Symmetrel; Ciba-Geigy Brand of Amantadine Hydrochloride; Ciba Geigy Brand of Amantadine Hydrochloride; Novartis Brand of Amantadine Hydrochloride; Endantadine; Endo Brand of Amantadine Hydrochloride; Mantadix; Alliance Brand of Amantadine Hydrochloride; Du Pont Brand of Amantadine Hydrochloride; Viregyt; Thiemann Brand of Amantadine Hydrochloride; Wiregyt; tregor; Hormosan Brand of Amantadine Sulfate; Amanta-Sulfate-AZU; Amanta Sulfate AZU; AmantaSulfateAZU; Azupharma Brand of Amantadine Sulfate; Amantadin AZU; AZU, Amantadin; Adekin; Desitin Brand of Amantadine Hydrochloride; Aman; Neuro Hexal Brand of Amantadine Sulfate; Hexal Brand of Amantadine Sulfate; Amanta; AbZ Brand of Amantadine Hydrochloride; Amanta-HCI-AZU; Amanta HCI AZU; AmantaHCIAZU; Azupharma Brand of Amantadine Hydrochloride; Amantadin AL; AL, Amantadin; Aliud Brand of Amantadine Sulfate; Amantadin Stada; Stada, Amantadin; Stada Brand of Amantadine Sulfate; Stada Brand of Amantadine Hydrochloride; Amantadin-ratiopharm; Amantadin ratiopharm; Amantadinratiopharm; ratiopharm Brand of Amantadine Hydrochloride; Amantadina Juventus; Juventus, Amantadina; Juventus Brand of Amantadine Hydrochloride;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antiparkinson Agents; Antiviral Agents; Dopamine Agents; Analgesics, Non-Narcotic;

Tree Number: D02.455.426.100.050.035;

History Note: 68(65)