Amino Acid Substitution - Genetics
Research News and Information

Monday, November 23, 2009

Generation of a human immunodeficiency virus type 1 chronically infected monkey B cell line expressing low levels of endogenous TRIM5alpha.

29 Nov 2009 Several innate cellular antiviral factors exist in mammalian cells that prevent the replication of retroviruses. Among them, the tripartite motif protein (TRIM)5alpha has been shown to block human immunodeficiency virus type 1 (HIV-1) infection in ... Read more...

Crystallographic and activity-based evidence for thumb flexibility and its relevance in glycoside hydrolase family 11 xylanases.

30 Oct 2009 Enzyme intramolecular mobility and conformational changes of loops in particular play a significant role in biocatalysis. In this respect, the highly conserved thumb loop of glycoside hydrolase family (GH) 11 xylanases is an intriguing and ... Read more...

KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.

24 Oct 2009 Human killer cell immunoglobulin-like receptors (KIRs) are distinguished by expansion of activating KIR2DS, whose ligands and functions remain poorly understood. The oldest, most prevalent KIR2DS is KIR2DS4, which is represented by a variable ... Read more...

Latest indexed articles for 'Amino Acid Substitution - Genetics'

These are the very latest articles for this heading:

• Generation of a human immunodeficiency virus type 1 chronically infected monkey B cell line expressing low levels of endogenous TRIM5alpha. 29 Nov 2009
• Crystallographic and activity-based evidence for thumb flexibility and its relevance in glycoside hydrolase family 11 xylanases. 30 Oct 2009
• KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C. 24 Oct 2009
• The outermost N-terminal region of tapasin facilitates folding of major histocompatibility complex class I. 29 Sep 2009
• Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes. 29 Sep 2009
• Biochemical consequences of sedlin mutations that cause spondyloepiphyseal dysplasia tarda. 23 Sep 2009
• The novel Y371D myocilin mutation causes an aggressive form of juvenile open-angle glaucoma in a Caucasian family from the Middle-East. 22 Sep 2009
• Residues in the H+ translocation site define the pKa for sugar binding to LacY. 20 Sep 2009
• Structural basis for differential binding of the interleukin-8 monomer and dimer to the CXCR1 N-domain: role of coupled interactions and dynamics. 20 Sep 2009
• Use of stabilizing mutations to engineer a charged group within a ligand-binding hydrophobic cavity in T4 lysozyme. 20 Sep 2009
• Resonance Raman spectra of an O2-binding H-NOX domain reveal heme relaxation upon mutation. 13 Sep 2009
• Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402. 12 Sep 2009
• The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation. 12 Sep 2009
• Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. 7 Sep 2009
• The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu. 6 Sep 2009
• The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis. 2 Sep 2009
• A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export. 31 Aug 2009
• Genetic diversity and drug resistance of HIV type 1 circulating recombinant Form_BC among drug users in Guangdong Province. 30 Aug 2009
• Failure of treatment with first-line lopinavir boosted with ritonavir can be explained by novel resistance pathways with protease mutation 76V. 30 Aug 2009
• Genetic diversity of human papillomavirus type 16 E6, E7, and L1 genes in Italian women with different grades of cervical lesions. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Amino Acid Substitution'

Definition: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.

Descriptor UI: D019943

Alternative terms: Amino Acid Substitution; Amino Acid Substitutions; Substitution, Amino Acid; Substitutions, Amino Acid;

Related Mesh Headings: Mutagenesis, Site-Directed; Mutation, Missense;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: E05.393.420.601.035; G05.355.600.109;

History Note: 98