Amino Acid Substitution
Research News and Information

Saturday, November 21, 2009

The JAL antigen (RH48) is the result of a change in RHCE that encodes Arg114Trp.

21 Dec 2009 BACKGROUND: The JAL antigen (Rh48) was discovered more than 30 years ago when it caused hemolytic disease of the fetus and newborn in an African American family. A decade later it was found to cause hemolytic disease of the fetus and newborn in a ... Read more...

Generation of a human immunodeficiency virus type 1 chronically infected monkey B cell line expressing low levels of endogenous TRIM5alpha.

29 Nov 2009 Several innate cellular antiviral factors exist in mammalian cells that prevent the replication of retroviruses. Among them, the tripartite motif protein (TRIM)5alpha has been shown to block human immunodeficiency virus type 1 (HIV-1) infection in ... Read more...

Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval.

29 Nov 2009 ClC-2 chloride channel is present in the brain and some transporting epithelia where its function is poorly understood. We have now demonstrated that the surface channels are rapidly internalised and approximately the 70% of the surface membrane ... Read more...

Latest indexed articles for 'Amino Acid Substitution'

These are the very latest articles for this heading:

• The JAL antigen (RH48) is the result of a change in RHCE that encodes Arg114Trp. 21 Dec 2009
• Generation of a human immunodeficiency virus type 1 chronically infected monkey B cell line expressing low levels of endogenous TRIM5alpha. 29 Nov 2009
• Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. 29 Nov 2009
• Crystallographic and activity-based evidence for thumb flexibility and its relevance in glycoside hydrolase family 11 xylanases. 30 Oct 2009
• Hereditary multiple exostoses and juvenile colon carcinoma: A case with a common genetic background? 30 Oct 2009
• The IL-8 production by Streptococcal pyrogenic exotoxin B. 30 Oct 2009
• Trends in the epidemiology of human G1P[8] rotaviruses: a hungarian study. 30 Oct 2009
• Granzyme A is a proinflammatory protease. 27 Oct 2009
• KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C. 24 Oct 2009
• Real time monitoring of sickle cell hemoglobin fiber formation by UV resonance Raman spectroscopy. 18 Oct 2009
• Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription. 18 Oct 2009
• Novel binding motif of ACTH analogues at the melanocortin receptors. 18 Oct 2009
• AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. 14 Oct 2009
• Residues K128, 132, and 134 in the thyroid hormone receptor-alpha are essential for receptor acetylation and activity. 7 Oct 2009
• An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells. 2 Oct 2009
• A motor driving PTEN. 29 Sep 2009
• The outermost N-terminal region of tapasin facilitates folding of major histocompatibility complex class I. 29 Sep 2009
• Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes. 29 Sep 2009
• Reversal of coenzyme specificity of 2,3-butanediol dehydrogenase from Saccharomyces cerevisae and in vivo functional analysis. 29 Sep 2009
• Malignant hyperthermia-like syndrome and carnitine palmitoyltransferase II deficiency with heterozygous R503C mutation. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Amino Acid Substitution'

Definition: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.

Descriptor UI: D019943

Alternative terms: Amino Acid Substitution; Amino Acid Substitutions; Substitution, Amino Acid; Substitutions, Amino Acid;

Related Mesh Headings: Mutagenesis, Site-Directed; Mutation, Missense;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: E05.393.420.601.035; G05.355.600.109;

History Note: 98