Amino Acid Substitution - Research News and Information

Wednesday, January 07, 2009

Crystal structures of the starch-binding domain from Rhizopus oryzae glucoamylase reveal a polysaccharide-binding path.

13 Nov 2008 GA (glucoamylase) hydrolyses starch and polysaccharides to beta-D-glucose. RoGA (Rhizopus oryzae GA) consists of two functional domains, an N-terminal SBD (starch-binding domain) and a C-terminal catalytic domain, which are connected by an ... Read more...

Directionality in the evolution of influenza A haemagglutinin.

5 Nov 2008 The evolution of haemagglutinin (HA), an important influenza virus antigen, has been the subject of intensive research for more than two decades. Many characteristics of HA's sequence evolution are captured by standard Markov chain substitution ... Read more...

Association of bone morphogenetic protein 4 gene polymorphisms with nonsyndromic cleft lip with or without cleft palate in Chinese children.

30 Oct 2008 Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is one of the most common congenital anomalies in humans. The pathogenesis of nsCL/P involves both genetic and environmental factors. On the basis of linkage data suggesting that 14q21-24 ... Read more...

Learn Faster Today      Improve your study skills

Latest indexed articles for 'Amino Acid Substitution'

These are the very latest articles for this heading:

• Crystal structures of the starch-binding domain from Rhizopus oryzae glucoamylase reveal a polysaccharide-binding path. 13 Nov 2008
• Directionality in the evolution of influenza A haemagglutinin. 5 Nov 2008
• Association of bone morphogenetic protein 4 gene polymorphisms with nonsyndromic cleft lip with or without cleft palate in Chinese children. 30 Oct 2008
• Clinical significance of a set of single nucleotide polymorphisms of hepatitis B virus core gene in Chinese Han patients with chronic hepatitis B. 30 Oct 2008
• Natural polymorphisms in HIV-1 protease: impact on effectiveness of a first-line lopinavir-containing antiretroviral therapy regimen. 30 Oct 2008
• Inheritance of L1014F and M918T sodium channel mutations associated with pyrethroid resistance in Myzus persicae. 21 Oct 2008
• Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1. 14 Oct 2008
• Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus. 13 Oct 2008
• Activation of human peripheral IgM+ B cells is transiently inhibited by BCR-independent aggregation of Fc gammaRIIB. 13 Oct 2008
• Molecular studies of pH-dependent ligand interactions with the low-density lipoprotein receptor. 9 Oct 2008
• Proton-dependent electron transfer from CuA to heme a and altered EPR spectra in mutants close to heme a of cytochrome oxidase. 9 Oct 2008
• Structural characterization of a thiazoline-containing chromophore in an orange fluorescent protein, monomeric Kusabira Orange. 8 Oct 2008
• Genome wide identification of recessive cancer genes by combinatorial mutation analysis. 8 Oct 2008
• Conformationally gated metal uptake by apomanganese superoxide dismutase. 7 Oct 2008
• Different structural changes occur in blue- and green-proteorhodopsins during the primary photoreaction. 7 Oct 2008
• The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. 3 Oct 2008
• Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis. 2 Oct 2008
• Discarding functional residues from the substitution table improves predictions of active sites within three-dimensional structures. Oct 2008
• Ethnicity determines association of p53Arg72Pro alleles with cervical cancer in China. 29 Sep 2008
• Amyloid fibril composition is related to the phenotype of hereditary transthyretin V30M amyloidosis. 29 Sep 2008

See a longer list of these articles.

Technical information about 'Amino Acid Substitution'

Definition: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.

Descriptor UI: D019943

Alternative terms: Amino Acid Substitution; Amino Acid Substitutions; Substitution, Amino Acid; Substitutions, Amino Acid;

Related Mesh Headings: Mutagenesis, Site-Directed; Mutation, Missense;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: E05.393.420.601.035; G05.355.600.109;

History Note: 98