Aminopyridines - Research News and Information

Wednesday, January 07, 2009

Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis.

30 Sep 2008 Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system that results in persistent impairment in young adults. During chronic progressive disease stages, there is a strong correlation between neurodegeneration and ... Read more...

A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice.

29 Sep 2008 Although acute lung injury contributes significantly to critical illness, resolution often occurs spontaneously via activation of incompletely understood pathways. We recently found that mechanical ventilation of mice increases the level of ... Read more...

Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice.

26 Aug 2008 BACKGROUND: We reported that roflumilast, a phosphodiesterase 4 inhibitor, given orally at 5 mg/kg to mice prevented the development of emphysema in a chronic model of cigarette smoke exposure, while at 1 mg/kg was ineffective. Here we investigated ... Read more...

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Latest indexed articles for 'Aminopyridines'

These are the very latest articles for this heading:

• Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. 30 Sep 2008
• A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. 29 Sep 2008
• [Local Treatment of stomatitis aphthosa] 30 Aug 2008
• Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice. 26 Aug 2008
• The reno-vascular A2B adenosine receptor protects the kidney from ischemia. 22 Jun 2008
• Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458). 12 Jun 2008
• Brain adenosine A2A receptor occupancy by a novel A1/A2A receptor antagonist, ASP5854, in rhesus monkeys: relationship to anticataleptic effect. 11 Jun 2008
• Curative effects of phosphodiesterase 4 inhibitors cilomilast, roflumilast, and rolipram in dermatitis mouse model. 7 Jun 2008
• Single-dose pharmacokinetics of roflumilast in children and adolescents. 26 May 2008
• 5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats. 22 May 2008
• Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors. 15 May 2008
• Activation of the serotonergic 5-HT1A receptor in the paraventricular nucleus of the hypothalamus inhibits water intake and increases urinary excretion in water-deprived rats. 12 May 2008
• CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes. 29 Apr 2008
• Chromatographic deuterium isotope effects of derivatized N-glycans and N-glycopeptides in a zwitterionic type of hydrophilic interaction chromatography. 29 Apr 2008
• Roflumilast: an oral, once-daily selective PDE-4 inhibitor for the management of COPD and asthma. 29 Apr 2008
• Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors. 23 Apr 2008
• Reactivity of an aminopyridine [LMnII]2+ complex with H2O2. Detection of intermediates at low temperature. 19 Apr 2008
• Combining docking, molecular dynamics and the linear interaction energy method to predict binding modes and affinities for non-nucleoside inhibitors to HIV-1 reverse transcriptase. 10 Apr 2008
• Rare examples of base pairing via a protonated pyridine N atom in two salts of N2,N6-bis(1,3-dimethylimidazolin-2-ylidene)pyridine-2,6-diamine. 7 Apr 2008
• Systematic review of therapeutic interventions in human prion disease. 6 Apr 2008

See a longer list of these articles.

Technical information about 'Aminopyridines'

Definition: Pyridines substituted in any position with an amino group. May be hydrogenated, but must retain at least one double bond.

Registry Number: 0

Descriptor UI: D000631

Alternative terms: Aminopyridines;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.092.080; D03.383.725.050;

History Note: 79

Technical Notes: = pyridinamines & pyridylamines