Amphetamine
Research News and Information

Saturday, November 21, 2009

Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation.

30 Oct 2009 We tested the hypothesis that increased dopaminergic sensitivity induced by olfactory bulbectomy is mediated by dysregulation of endocannabinoid signaling. Bilateral olfactory bulbectomy induces behavioral and neurobiological symptomatology related ... Read more...

Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature.

29 Sep 2009 An amphetamine (AMPH) regimen that does not produce a prominent blood-brain barrier breakdown was shown to significantly alter the expression of genes regulating vascular tone, immune function, and angiogenesis in vasculature associated with ... Read more...

A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men.

29 Sep 2009 CONTEXT: Bipolar mania and schizophrenia are recognized as separate disorders but share many commonalities, which raises the question of whether they are the same disorder on different ends of a continuum. The lack of distinct endophenotypes of ... Read more...

Latest indexed articles for 'Amphetamine'

These are the very latest articles for this heading:

• Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation. 30 Oct 2009
• Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. 29 Sep 2009
• A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men. 29 Sep 2009
• Effects of omeprazole on the pharmacokinetic profiles of lisdexamfetamine dimesylate and extended-release mixed amphetamine salts in adults. 30 Aug 2009
• Dopaminergic response to graded dopamine concentration elicited by four amphetamine doses. 30 Aug 2009
• DNA-based MRI probes for specific detection of chronic exposure to amphetamine in living brains. 24 Aug 2009
• Amphetamine reduces vesicular dopamine content in dexamethasone-differentiated PC12 cells only following L-DOPA exposure. 20 Aug 2009
• A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. 30 Jul 2009
• Dopaminergic activity in depressed smokers: a positron emission tomography study. 30 Jul 2009
• Fast oscillations in cortical-striatal networks switch frequency following rewarding events and stimulant drugs. 29 Jul 2009
• Corticostriatal dysfunction underlies diminished striatal ascorbate release in the R6/2 mouse model of Huntington's disease. 14 Jul 2009
• Changes in hyporesponsiveness to acute amphetamine and age differences in tyrosine hydroxylase immunoreactivity in the brain over adolescence in male and female rats. 29 Jun 2009
• Amphetamine- and nicotine-induced cross-sensitization in adolescent rats persists until adulthood. 29 Jun 2009
• Cardiac safety of methylphenidate versus amphetamine salts in the treatment of ADHD. 29 Jun 2009
• Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. 22 Jun 2009
• Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task. 15 Jun 2009
• Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. 8 Jun 2009
• Amphetamine-evoked rotation requires newly synthesized dopamine at 14 days but not 1 day after intranigral 6-OHDA and is consistently dissociated from sensorimotor behavior. 6 Jun 2009
• Distribution of methamphetamine and amphetamine in drug abusers' head hair. 3 Jun 2009
• Effects of amphetamine on salivary secretion. 30 May 2009

See a longer list of these articles.

Technical information about 'Amphetamine'

Definition: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.

Chemical name: Benzeneethanamine, alpha-methyl-, (+-)-

Registry Number: 300-62-9

Descriptor UI: D000661

Alternative terms: Amphetamine; Phenopromin; Phenamine; Amfetamine; Desoxynorephedrin; Fenamine; Centramina; Miquel Brand of Amfetamine Sulfate; Mydrial; Thyramine; Amphetamine Sulfate; Sulfate, Amphetamine; Amphetamine Sulfate (2:1); l-Amphetamine; l Amphetamine; Levoamphetamine; levo-Amphetamine; levo Amphetamine;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Central Nervous System Stimulants; Sympathomimetics; Dopamine Agents; Adrenergic Agents; Adrenergic Uptake Inhibitors; Dopamine Uptake Inhibitors;

Tree Number: D02.092.471.683.152.110;

Technical Notes: a specific chem: do not confuse with AMPHETAMINES; d-amphetamine = DEXTROAMPHETAMINE; N-methylamphetamine = METHAMPHETAMINE