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Amyloid beta-Protein - Antagonists & inhibitors
Research News and Information
Definition of 'Amyloid beta-Protein'A 4-kDa protein, 39-43 amino acids long, expressed by a gene located on chromosome 21. It is the major protein subunit of the vascular and plaque amyloid filaments in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The protein is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue. Common names: Amyloid beta-Protein; Amyloid beta Protein; beta-Protein, Amyloid; Alzheimer beta-Protein; Alzheimer beta Protein; beta-Protein, Alzheimer; Amyloid AD-AP; AD-AP, Amyloid; Amyloid AD AP; Amyloid Protein A4; Protein A4, Amyloid; beta-Amyloid Protein; Protein, beta-Amyloid; beta Amyloid Protein |
Sunday, November 22, 2009
Reelin signaling antagonizes beta-amyloid at the synapse.
31 Aug 2009 
Abnormal processing of the amyloid precursor protein (APP) and beta-amyloid (Abeta) plaque accumulation are defining features of Alzheimer disease (AD), a genetically complex neurodegenerative disease that is characterized by progressive synapse ... Read more...
31 Aug 2009 Alzheimer's disease (AD) is characterized by synaptic dysfunction and cardinal neuropathological features including amyloid plaques and neurofibrillary tangles. Soluble amyloid-beta (Abeta) can suppress synaptic activities by interacting with alpha7 ... Read more...
Identification of an antiamyloidogenic substance from mulberry leaves.
24 Aug 2009 Fibrillar aggregates of amyloid beta-peptides are major constituents of the plaques found in the brains of patients with Alzheimer's disease, and have been implicated in the neurotoxicity of Alzheimer's. We previously reported that the methanol ... Read more...
Latest indexed articles for 'Amyloid beta-Protein - Antagonists & inhibitors'
These are the very latest articles for this heading:
- Reelin signaling antagonizes beta-amyloid at the synapse. 31 Aug 2009
- Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain. 31 Aug 2009
- Identification of an antiamyloidogenic substance from mulberry leaves. 24 Aug 2009
- Inhibition of Abeta42 aggregation using peptides selected from combinatorial libraries. 30 Jul 2009
- Inhibitors of protein aggregation and toxicity. 30 Jul 2009
- Akebia saponin D, a saponin component from Dipsacus asper Wall, protects PC 12 cells against amyloid-beta induced cytotoxicity. 13 Jul 2009
- Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity. 29 Jun 2009
- Development of vaccination approaches for the treatment of neurological diseases. 29 Jun 2009
- Neuroprotective effect of epigallocatechin-3-gallate against beta-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity. 24 Jun 2009
- Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity. 9 Jun 2009
- Differential effects of gamma-secretase and BACE1 inhibition on brain Abeta levels in vitro and in vivo. 8 Jun 2009
- Acteoside protects human neuroblastoma SH-SY5Y cells against beta-amyloid-induced cell injury. 7 Jun 2009
- Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro. 7 Jun 2009
- Pharmacology of the intracellular pathways activated by amyloid beta protein. 30 May 2009
- Rationally designed dehydroalanine (DeltaAla)-containing peptides inhibit amyloid-beta (Abeta) peptide aggregation. 30 May 2009
- Comparative study of inhibition at multiple stages of amyloid-beta self-assembly provides mechanistic insight. 27 May 2009
- Computational selection of inhibitors of Abeta aggregation and neuronal toxicity. 25 May 2009
- Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells. 19 May 2009
- Alpha-helix targeting reduces amyloid-beta peptide toxicity. 18 May 2009
- The amyloid hypothesis for Alzheimer's disease: a critical reappraisal. 16 May 2009
See a longer list of these articles.
Technical information about 'Amyloid beta-Protein'
Definition: A 4-kDa protein, 39-43 amino acids long, expressed by a gene located on chromosome 21. It is the major protein subunit of the vascular and plaque amyloid filaments in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The protein is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
Registry Number: 0
Descriptor UI: D016229
Alternative terms: Amyloid beta-Protein; Amyloid beta Protein; beta-Protein, Amyloid; Alzheimer beta-Protein; Alzheimer beta Protein; beta-Protein, Alzheimer; Amyloid AD-AP; AD-AP, Amyloid; Amyloid AD AP; Amyloid Protein A4; Protein A4, Amyloid; beta-Amyloid Protein; Protein, beta-Amyloid; beta Amyloid Protein; ABP (Alzheimer's); Amyloid Fibril Protein (Alzheimer's);
Related Mesh Headings: Cerebral Amyloid Angiopathy;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.776.049.025;
History Note: 91
Technical Notes: /biosyn /drug eff /physiol /ultrastruct permitted