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Amyloid beta-Protein - Metabolism
Research News and Information
Definition of 'Amyloid beta-Protein'A 4-kDa protein, 39-43 amino acids long, expressed by a gene located on chromosome 21. It is the major protein subunit of the vascular and plaque amyloid filaments in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The protein is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue. Common names: Amyloid beta-Protein; Amyloid beta Protein; beta-Protein, Amyloid; Alzheimer beta-Protein; Alzheimer beta Protein; beta-Protein, Alzheimer; Amyloid AD-AP; AD-AP, Amyloid; Amyloid AD AP; Amyloid Protein A4; Protein A4, Amyloid; beta-Amyloid Protein; Protein, beta-Amyloid; beta Amyloid Protein |
Monday, November 23, 2009
Nov 2009 
Several different monoclonal antibodies (mAbs) have been actively developed in the field of Alzheimer's disease (AD) for basic science and clinical applications; however, the binding kinetics of many of the mAbs with the beta-amyloid peptides ... Read more...
30 Oct 2009 Neurofibrillary tangles and amyloid plaques are considered to be hallmarks of Alzheimer's disease (AD), and the toxic effects of amyloid-beta peptide (A beta) lead to activation of stress-related signaling and neuronal loss. The small heat shock ... Read more...
G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease.
18 Oct 2009 The beta-amyloid (Abeta) peptide is associated with the pathogenesis of Alzheimer's disease (AD). Evidence gathered over the last two decades suggests that the gradual accumulation of soluble and insoluble Abeta peptide species triggers a cascade of ... Read more...
Latest indexed articles for 'Amyloid beta-Protein - Metabolism'
These are the very latest articles for this heading:
- Surface plasmon resonance binding kinetics of Alzheimer's disease amyloid beta peptide-capturing and plaque-binding monoclonal antibodies. Nov 2009
- The small heat shock protein Hsp27 protects cortical neurons against the toxic effects of beta-amyloid peptide. 30 Oct 2009
- G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease. 18 Oct 2009
- gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. 12 Oct 2009
- The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. 12 Oct 2009
- Axonal transport defects in neurodegenerative diseases. 12 Oct 2009
- A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease. 29 Sep 2009
- Bleeding in the brain: Amyloid-beta may keep clots away.
29 Sep 2009 - Hypoxia and neurodegeneration. 29 Sep 2009
- Amyloid-beta(1-42) fibrillar precursors are optimal for inducing tumor necrosis factor-alpha production in the THP-1 human monocytic cell line. 27 Sep 2009
- CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. 21 Sep 2009
- Two disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability. 20 Sep 2009
- Induced beta-barrel formation of the Alzheimer's Abeta25-35 oligomers on carbon nanotube surfaces: implication for amyloid fibril inhibition. 14 Sep 2009
- Identification and characterisation of the novel amyloid-beta peptide-induced protein p17. 11 Sep 2009
- Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. 8 Sep 2009
- Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta. 7 Sep 2009
- An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein. 31 Aug 2009
- Preparation of fluorescently-labeled amyloid-beta peptide assemblies: the effect of fluorophore conjugation on structure and function. 30 Aug 2009
- Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels. 30 Aug 2009
- Isolation and biochemical characterization of amyloid plaques and paired helical filaments. 30 Aug 2009
See a longer list of these articles.
Technical information about 'Amyloid beta-Protein'
Definition: A 4-kDa protein, 39-43 amino acids long, expressed by a gene located on chromosome 21. It is the major protein subunit of the vascular and plaque amyloid filaments in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The protein is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
Registry Number: 0
Descriptor UI: D016229
Alternative terms: Amyloid beta-Protein; Amyloid beta Protein; beta-Protein, Amyloid; Alzheimer beta-Protein; Alzheimer beta Protein; beta-Protein, Alzheimer; Amyloid AD-AP; AD-AP, Amyloid; Amyloid AD AP; Amyloid Protein A4; Protein A4, Amyloid; beta-Amyloid Protein; Protein, beta-Amyloid; beta Amyloid Protein; ABP (Alzheimer's); Amyloid Fibril Protein (Alzheimer's);
Related Mesh Headings: Cerebral Amyloid Angiopathy;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.776.049.025;
History Note: 91
Technical Notes: /biosyn /drug eff /physiol /ultrastruct permitted