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Amyloid beta-Protein - Toxicity
Research News and Information
Definition of 'Amyloid beta-Protein'A 4-kDa protein, 39-43 amino acids long, expressed by a gene located on chromosome 21. It is the major protein subunit of the vascular and plaque amyloid filaments in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The protein is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue. Common names: Amyloid beta-Protein; Amyloid beta Protein; beta-Protein, Amyloid; Alzheimer beta-Protein; Alzheimer beta Protein; beta-Protein, Alzheimer; Amyloid AD-AP; AD-AP, Amyloid; Amyloid AD AP; Amyloid Protein A4; Protein A4, Amyloid; beta-Amyloid Protein; Protein, beta-Amyloid; beta Amyloid Protein |
Monday, November 23, 2009
20 Sep 2009 
Interaction between aggregates of amyloid beta protein (Abeta) and membranes has been hypothesized by many to be a key event in the mechanism of neurotoxicity associated with Alzheimer's disease (AD). Proposed membrane-related mechanisms of ... Read more...
18 Aug 2009 The neurotoxicity of aggregated beta-amyloid (Abeta) has been implicated as a critical cause in the pathogenesis of Alzheimer's disease (AD). It can cause neurotoxicity in AD by evoking a cascade of oxidative damage-dependent apoptosis to neurons. ... Read more...
17 Aug 2009 In several epidemiological studies, moderate ethanol consumption has been associated with reduced risks of cognitive decline or Alzheimer's dementia. Of potential relevance is that brain cultures preconditioned with moderate ethanol concentrations ... Read more...
Latest indexed articles for 'Amyloid beta-Protein - Toxicity'
These are the very latest articles for this heading:
- Two disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability. 20 Sep 2009
- Protective effect of pyrroloquinoline quinone against Abeta-induced neurotoxicity in human neuroblastoma SH-SY5Y cells. 18 Aug 2009
- Essential involvement of the NMDA receptor in ethanol preconditioning-dependent neuroprotection from amyloid-betain vitro. 17 Aug 2009
- Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells. 15 Aug 2009
- Protein phosphatase 5 protects neurons against amyloid-beta toxicity. 15 Aug 2009
- Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling. 13 Aug 2009
- Structure-neurotoxicity relationships of amyloid beta-protein oligomers. 10 Aug 2009
- Protective effects of Wu-Zi-Yan-Zong-Fang on amyloid beta-induced damage in vivo and in vitro. 30 Jul 2009
- Biological markers in cerebrospinal fluid (CSF) and evaluation of in vitro effect of CSF on PC12 cell line viability in Alzheimer's disease. 30 Jul 2009
- Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice. 26 Jul 2009
- Potential protection of curcumin against amyloid beta-induced toxicity on cultured rat prefrontal cortical neurons. 20 Jul 2009
- Immunodominant epitope and properties of pyroglutamate-modified Abeta-specific antibodies produced in rabbits. 7 Jul 2009
- Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice. 6 Jul 2009
- Influence of residue 22 on the folding, aggregation profile, and toxicity of the Alzheimer's amyloid beta peptide. 6 Jul 2009
- Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. 4 Jul 2009
- Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity. 29 Jun 2009
- Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by beta-amyloid 25-35 fragment. 29 Jun 2009
- The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide. 20 Jun 2009
- Cyclodextrins promote protein aggregation posing risks for therapeutic applications. 16 Jun 2009
- Antioxidant effects of epicatechin on the hippocampal toxicity caused by amyloid-beta 25-35 in rats. 15 Jun 2009
See a longer list of these articles.
Technical information about 'Amyloid beta-Protein'
Definition: A 4-kDa protein, 39-43 amino acids long, expressed by a gene located on chromosome 21. It is the major protein subunit of the vascular and plaque amyloid filaments in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The protein is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
Registry Number: 0
Descriptor UI: D016229
Alternative terms: Amyloid beta-Protein; Amyloid beta Protein; beta-Protein, Amyloid; Alzheimer beta-Protein; Alzheimer beta Protein; beta-Protein, Alzheimer; Amyloid AD-AP; AD-AP, Amyloid; Amyloid AD AP; Amyloid Protein A4; Protein A4, Amyloid; beta-Amyloid Protein; Protein, beta-Amyloid; beta Amyloid Protein; ABP (Alzheimer's); Amyloid Fibril Protein (Alzheimer's);
Related Mesh Headings: Cerebral Amyloid Angiopathy;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.776.049.025;
History Note: 91
Technical Notes: /biosyn /drug eff /physiol /ultrastruct permitted