Amyloid beta-Protein Precursor - Metabolism
Research News and Information

Sunday, March 21, 2010

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

12 Oct 2009 Amyloid beta protein (Abeta), a pathogenic molecule associated with Alzheimer's disease, is produced by gamma-secretase, which cleaves the beta-carboxyl terminal fragment (betaCTF) of beta-amyloid precursor protein in the middle of its transmembrane ... Read more...

Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells.

29 Sep 2009 FE65 is a neural adaptor protein known to interact with a number of proteins, including Alzheimer's amyloid beta-protein precursor (APP). Although several different functions have been proposed for FE65, its primary physiological role remains ... Read more...

[The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain]

28 Sep 2009 Aging itself is considered as a major risk factor of dementia. The prevalence of the Alzheimer's disease (AD) is increasing exponentially after the age of 65 and doubles every 5 years. The major aim of our present research was to examine the effect ... Read more...

Latest indexed articles for 'Amyloid beta-Protein Precursor - Metabolism'

These are the very latest articles for this heading:

• gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. 12 Oct 2009
• Bleeding in the brain: Amyloid-beta may keep clots away. 29 Sep 2009
• Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells. 29 Sep 2009
• [The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain] 28 Sep 2009
• Neuropathy target esterase is required for adult vertebrate axon maintenance. 14 Sep 2009
• Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. 8 Sep 2009
• Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. 31 Aug 2009
• Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress. 30 Aug 2009
• Plasminogen activator inhibitors regulate cell adhesion through a uPAR-dependent mechanism. 30 Aug 2009
• Insulin resistance and Alzheimer's disease. 29 Aug 2009
• Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations. 3 Aug 2009
• DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. 30 Jul 2009
• Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites. 20 Jul 2009
• Amyloid precursor protein, heat-shock proteins, and Bcl-2 form a complex in mitochondria and modulate mitochondria function and apoptosis in N2a cells. 17 Jul 2009
• Caspase substrates and neurodegenerative diseases. 14 Jul 2009
• Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. 8 Jul 2009
• Vascular endothelial growth factor (VEGF) affects processing of amyloid precursor protein and beta-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain. 5 Jul 2009
• Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress. 29 Jun 2009
• Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributions. 29 Jun 2009
• Role of n-type voltage-dependent calcium channels in autoimmune optic neuritis. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Amyloid beta-Protein Precursor'

Definition: A precursor to the AMYLOID-BETA PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging.

Registry Number: 0

Descriptor UI: D016564

Alternative terms: Amyloid beta-Protein Precursor; Amyloid beta Protein Precursor; beta-Protein Precursor, Amyloid; Amyloid beta Precursor Protein; Amyloid A4 Protein Precursor; beta-Amyloid Protein Precursor; beta Amyloid Protein Precursor; Amyloid Protein Precursor;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.049.025.150; D12.776.811.050;

Online Note: use AMYLOID BETA-PROTEIN PRECURSOR (NM) to search AMYLOID BETA-PROTEIN PRECURSOR 1988-91 & AMYLOID A4 PROTEIN PRECURSOR 1987-94

History Note: 92; was AMYLOID BETA PROTEIN PRECURSOR (NM) 1988-91; AMYLOID A4 PROTEIN PRECURSOR was NM 1987-94

Technical Notes: /drug eff /ultrastruct permitted; DF: ABPP