Amyloid beta-Protein Precursor - Research News and Information

Wednesday, January 07, 2009

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.

18 Oct 2008 Neuronal activity has an impact on beta cleavage of amyloid precursor protein (APP) by BACE1 to generate amyloid-beta peptide (Abeta). However, the molecular mechanisms underlying this effect remain to be elucidated. Cholesterol dependency of beta ... Read more...

Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

6 Oct 2008 Recent studies suggest that subtype-selective activators of M(1)/M(4) muscarinic acetylcholine receptors (mAChRs) may offer a novel approach for the treatment of psychotic symptoms associated with schizophrenia and Alzheimer's disease. Previously ... Read more...

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses.

29 Sep 2008 The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early successes in identifying three genes that cause early-onset familial AD (those that encode amyloid precursor protein (APP) and the presenilins (PSEN1 and ... Read more...

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Latest indexed articles for 'Amyloid beta-Protein Precursor'

These are the very latest articles for this heading:

• Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing. 18 Oct 2008
• Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. 6 Oct 2008
• Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. 29 Sep 2008
• Exercise training acts as a therapeutic strategy for reduction of the pathogenic phenotypes for Alzheimer's disease in an NSE/APPsw-transgenic model. 29 Sep 2008
• Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice. 15 Sep 2008
• p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease. 9 Sep 2008
• Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. 8 Sep 2008
• The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease. 30 Aug 2008
• Proinflammatory stimuli are needed for induction of microglial cell-mediated AbetaPP_{244-C} and Abeta-neurotoxicity in hippocampal cultures. 30 Aug 2008
• SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. 30 Aug 2008
• Negative regulation of AbetaPP gene expression by pur-alpha. 30 Aug 2008
• Distinct effects of testosterone on plasma and cerebrospinal fluid amyloid-beta levels. 30 Aug 2008
• The many faces of amyloid beta in Alzheimer's disease. 30 Aug 2008
• Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. 27 Aug 2008
• BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. 25 Aug 2008
• NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons. 24 Aug 2008
• Swedish amyloid precursor protein mutation increases cell cycle-related proteins in vitro and in vivo. 13 Aug 2008
• Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? 13 Aug 2008
• The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis. 13 Aug 2008
• Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. 9 Aug 2008

See a longer list of these articles.

Technical information about 'Amyloid beta-Protein Precursor'

Definition: A precursor to the AMYLOID-BETA PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging.

Registry Number: 0

Descriptor UI: D016564

Alternative terms: Amyloid beta-Protein Precursor; Amyloid beta Protein Precursor; beta-Protein Precursor, Amyloid; Amyloid beta Precursor Protein; Amyloid A4 Protein Precursor; beta-Amyloid Protein Precursor; beta Amyloid Protein Precursor; Amyloid Protein Precursor;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.049.025.150; D12.776.811.050;

Online Note: use AMYLOID BETA-PROTEIN PRECURSOR (NM) to search AMYLOID BETA-PROTEIN PRECURSOR 1988-91 & AMYLOID A4 PROTEIN PRECURSOR 1987-94

History Note: 92; was AMYLOID BETA PROTEIN PRECURSOR (NM) 1988-91; AMYLOID A4 PROTEIN PRECURSOR was NM 1987-94

Technical Notes: /drug eff /ultrastruct permitted; DF: ABPP