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Amyloid beta-Protein
Research News and Information
Definition of 'Amyloid beta-Protein'A 4-kDa protein, 39-43 amino acids long, expressed by a gene located on chromosome 21. It is the major protein subunit of the vascular and plaque amyloid filaments in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The protein is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue. Common names: Amyloid beta-Protein; Amyloid beta Protein; beta-Protein, Amyloid; Alzheimer beta-Protein; Alzheimer beta Protein; beta-Protein, Alzheimer; Amyloid AD-AP; AD-AP, Amyloid; Amyloid AD AP; Amyloid Protein A4; Protein A4, Amyloid; beta-Amyloid Protein; Protein, beta-Amyloid; beta Amyloid Protein |
Saturday, November 21, 2009
6 Dec 2009 
The main objective of this study was to determine whether elevated blood beta-amyloid (Abeta) levels among the first-degree relatives of patients with Alzheimer's Disease (AD) are associated with vascular risk factors of AD. Serum Abeta was measured ... Read more...
15 Nov 2009 
The overall morphology and Cu(II) ion coordination for the aggregated amyloid-beta(1-40) [Abeta(1-40)] in N-ethylmorpholine (NEM) buffer are affected by Cu(II) ion concentration. This effect is investigated by transmission electron microscopy (TEM), ... Read more...
Nov 2009 Several different monoclonal antibodies (mAbs) have been actively developed in the field of Alzheimer's disease (AD) for basic science and clinical applications; however, the binding kinetics of many of the mAbs with the beta-amyloid peptides ... Read more...
Latest indexed articles for 'Amyloid beta-Protein'
These are the very latest articles for this heading:
- High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patients. 6 Dec 2009
- The second Cu(II)-binding site in a proton-rich environment interferes with the aggregation of amyloid-beta(1-40) into amyloid fibrils. 15 Nov 2009
- Surface plasmon resonance binding kinetics of Alzheimer's disease amyloid beta peptide-capturing and plaque-binding monoclonal antibodies. Nov 2009
- The small heat shock protein Hsp27 protects cortical neurons against the toxic effects of beta-amyloid peptide. 30 Oct 2009
- Invited commentary.
30 Oct 2009 - Plasma amyloid beta42 and amyloid beta40 levels are associated with early cognitive dysfunction after cardiac surgery. 30 Oct 2009
- Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. 30 Oct 2009
- DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model. 26 Oct 2009
- G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease. 18 Oct 2009
- Alzheimer's biomarker initiative hits its stride. 14 Oct 2009
- gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. 12 Oct 2009
- Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. 12 Oct 2009
- Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. 12 Oct 2009
- The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. 12 Oct 2009
- Axonal transport defects in neurodegenerative diseases. 12 Oct 2009
- Relationships between biomarkers in aging and dementia. 11 Oct 2009
- A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease. 29 Sep 2009
- Bleeding in the brain: Amyloid-beta may keep clots away. 29 Sep 2009
- Hypoxia and neurodegeneration. 29 Sep 2009
- Ten-year change in plasma amyloid beta levels and late-life cognitive decline. 29 Sep 2009
See a longer list of these articles.
Technical information about 'Amyloid beta-Protein'
Definition: A 4-kDa protein, 39-43 amino acids long, expressed by a gene located on chromosome 21. It is the major protein subunit of the vascular and plaque amyloid filaments in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The protein is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
Registry Number: 0
Descriptor UI: D016229
Alternative terms: Amyloid beta-Protein; Amyloid beta Protein; beta-Protein, Amyloid; Alzheimer beta-Protein; Alzheimer beta Protein; beta-Protein, Alzheimer; Amyloid AD-AP; AD-AP, Amyloid; Amyloid AD AP; Amyloid Protein A4; Protein A4, Amyloid; beta-Amyloid Protein; Protein, beta-Amyloid; beta Amyloid Protein; ABP (Alzheimer's); Amyloid Fibril Protein (Alzheimer's);
Related Mesh Headings: Cerebral Amyloid Angiopathy;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.776.049.025;
History Note: 91
Technical Notes: /biosyn /drug eff /physiol /ultrastruct permitted