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Amyloid beta-Protein - Research News and Information
Wednesday, January 07, 2009
Definition of 'Amyloid beta-Protein'A 4-kDa protein, 39-43 amino acids long, expressed by a gene located on chromosome 21. It is the major protein subunit of the vascular and plaque amyloid filaments in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The protein is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue. Common names: Amyloid beta-Protein; Amyloid beta Protein; beta-Protein, Amyloid; Alzheimer beta-Protein; Alzheimer beta Protein; beta-Protein, Alzheimer; Amyloid AD-AP; AD-AP, Amyloid; Amyloid AD AP; Amyloid Protein A4; Protein A4, Amyloid; beta-Amyloid Protein; Protein, beta-Amyloid; beta Amyloid Protein |
9 Oct 2008 
Oxidative stress plays a key role in Alzheimer's disease (AD). In addition, the abnormally high Cu(2+) ion concentrations present in senile plaques has provoked a substantial interest in the relationship between the amyloid beta peptide (Abeta) ... Read more...
6 Oct 2008 The amyloid-beta (A beta) peptide (1-42) aggregation into oligomeric and fibrillar species affects neuronal viability, having a causal role in the development of Alzheimer's disease. Among dietary anthocyanins, cyanidin 3-O-glucoside (Cy-3G) and ... Read more...
Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers.
29 Sep 2008 The activation of the canonical Wnt signaling pathway protects hippocampal neurons against the toxicity of Alzheimer's amyloid-beta-peptide (Abeta), however, the role played by the Wnt receptors Frizzleds, has not been studied. We report here that ... Read more...
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Latest indexed articles for 'Amyloid beta-Protein'
These are the very latest articles for this heading:
- Amyloid-beta vaccination for Alzheimer's dementia.
16 Oct 2008 - Amyloid-beta vaccination for Alzheimer's dementia. 16 Oct 2008
- Amyloid beta-Cu2+ complexes in both monomeric and fibrillar forms do not generate H2O2 catalytically but quench hydroxyl radicals. 9 Oct 2008
- Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity. 6 Oct 2008
- Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers. 29 Sep 2008
- Exercise training acts as a therapeutic strategy for reduction of the pathogenic phenotypes for Alzheimer's disease in an NSE/APPsw-transgenic model. 29 Sep 2008
- Portal to Alzheimer's disease. 29 Sep 2008
- Biopsy support for the validity of Pittsburgh compound B positron emission tomography with a twist. 29 Sep 2008
- [Alzheimer vaccine] 29 Sep 2008
- Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. 26 Sep 2008
- Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. 19 Sep 2008
- Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. 17 Sep 2008
- Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice. 15 Sep 2008
- Imaging amyloid deposition in Lewy body diseases. 14 Sep 2008
- Cytokine-mediated inhibition of fibrillar amyloid-beta peptide degradation by human mononuclear phagocytes. 13 Sep 2008
- Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. 8 Sep 2008
- Intranasal insulin improves cognition and modulates beta-amyloid in early AD. 7 Sep 2008
- Identification of STC1 as an beta-amyloid activated gene in human brain microvascular endothelial cells using cDNA microarray. 7 Sep 2008
- Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease. 6 Sep 2008
- C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. 6 Sep 2008
See a longer list of these articles.
Technical information about 'Amyloid beta-Protein'
Definition: A 4-kDa protein, 39-43 amino acids long, expressed by a gene located on chromosome 21. It is the major protein subunit of the vascular and plaque amyloid filaments in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The protein is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
Registry Number: 0
Descriptor UI: D016229
Alternative terms: Amyloid beta-Protein; Amyloid beta Protein; beta-Protein, Amyloid; Alzheimer beta-Protein; Alzheimer beta Protein; beta-Protein, Alzheimer; Amyloid AD-AP; AD-AP, Amyloid; Amyloid AD AP; Amyloid Protein A4; Protein A4, Amyloid; beta-Amyloid Protein; Protein, beta-Amyloid; beta Amyloid Protein; ABP (Alzheimer's); Amyloid Fibril Protein (Alzheimer's);
Related Mesh Headings: Cerebral Amyloid Angiopathy;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.776.049.025;
History Note: 91
Technical Notes: /biosyn /drug eff /physiol /ultrastruct permitted